Results 31 to 40 of about 2,525,365 (152)

Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients [PDF]

Current Medical Mycology, 2019
Background and Purpose: Azoles are preferred antifungal agents given their inexpensiveness, limited toxicity, and potentiality of oral administration.
Sony Paul, Iyanar Kannan, Kalyani Mohanram   +2 more
doaj   +1 more source

Synthesis of new imidazole-based ionic liquids with antifungal activity against Candida albicans

Iranian Journal of Microbiology, 2023
Background and Objectives: Candida albicans cause a problematic condition in immunocompromised patients that could not be treated quickly due to the resistant behavior of microorganisms. This study aimed to investigate the effect of a novel ionic liquid
Amir Habibi, Mansour Bayat, Behinb Omidi, Ali Ezabadi, Pejman Mortazavi   +4 more
doaj   +1 more source

Investigation of the relationship between fluconazole susceptibility, proteinase activity and ERG11-SAP2 Expression in Candida albicans strains isolated from clinical samples [PDF]

Current Medical Mycology
Background and Purpose: Candida albicans is currently recognised as an opportunistic pathogen that can cause many invasive infections. Resistance mechanisms and fungal virulence factors play an important role in the effectiveness of treatment. The aim of
Nagihan Ege, Şükrü Öksüz, Emel Akbaş, Emel Çalişkan, Mehmet Sungur   +4 more
doaj   +1 more source

CDR1, CDR2, MDR1 and ERG11 expression in azole resistant Сandida albicans isolated from HIV-infected patients in city of Moscow

Инфекция и иммунитет, 2022
Candida fungi are common opportunistic microorganisms capable of causing infections of various localization, as well as life-threatening conditions in immunocompromised patients, such as HIV-infected individuals, oncology patients, subjects undergoing ...
A. D. Voropaev, D. A. Yekaterinchev, Y. N. Urban, V. V. Zverev, Yu. V. Nesvizhsky, E. A. Voropaeva, E. I. Likhanskaya, M. S. Afanasiev, S. S. Afanasiev   +8 more
doaj   +1 more source

A Crucial Role for Ergosterol in Plasma Membrane Composition, Localisation, and Activity of Cdr1p and H⁺-ATPase in Candida albicans

Microorganisms, 2019
Candida albicans is an opportunistic fungal pathogen of humans. Treatment of C. albicans infections relies on azoles, which target the lanosterol 14α-demethylase (Erg11p) encoded by the ERG11 gene.
Jakub Suchodolski, Jakub Muraszko, Przemysław Bernat, Anna Krasowska   +3 more
doaj   +1 more source

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Microbiology Spectrum, 2021
Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers   +5 more
doaj   +1 more source

Drug Resistance-Associated Mutations in ERG11 of Multidrug-Resistant Candida auris in a Tertiary Care Hospital of Eastern Saudi Arabia

Journal of Fungi, 2020
Candida auris is an emerging multi-drug resistant pathogen with high mortality rate; nosocomial infections have been reported worldwide, causing a major challenge for clinicians and microbiological laboratories. The study aims to describe new cases of C.
Reem AlJindan, Doaa M. AlEraky, Nehal Mahmoud, Baha Abdalhamid, Mashael Almustafa, Sayed AbdulAzeez, J. Francis Borgio   +6 more
doaj   +1 more source

Detection of antifungal drug-resistant and ERG11 gene mutations among clinical isolates of Candida species isolated from Khartoum, Sudan. [version 2; peer review: 2 approved, 1 not approved]

F1000Research, 2021
Background: Candida species are one of the most important opportunistic fungal pathogens that cause both superficial and systemic infections, especially in immunocompromised individuals.
Ahmed Osman Mohamed, Malik Suliman Mohamed, Mohamed Abdelrahman Hussain, Ibrahim Fatahalrahman Ahmed   +3 more
doaj   +1 more source

Molecular epidemiology and azole resistance mechanism study of Candida guilliermondii from a Chinese surveillance system

Scientific Reports, 2017
We studied the molecular epidemiology and mechanism of azole resistance of 164 C. guilliermondii isolates from a nationwide multi-center surveillance program.
Jing-Wei Cheng, Kang Liao, Timothy Kudinha, Shu-Ying Yu, Meng Xiao, He Wang, Fanrong Kong, Ying-Chun Xu   +7 more
doaj   +1 more source

The combined action of ERG11 gene overexpression and its mutations in the development of Candida albicans resistance to triazolic antifungals

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Modern medicine is faced with the resistance of Candida spp. to antimycotics, due to changes in the expression and structure of the ERG11 gene, the molecular target of triazoles.
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Vitaly V. Zverev, Alexander D. Voropaev, Maxim S. Afanasiev, Elena A. Voropaeva, Elena V. Budanova, Ludmila M. Smirnova, Sofia A. Anisova, Yulia N. Urban   +9 more
doaj   +1 more source