Results 31 to 40 of about 3,364 (161)

Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14α-demethylase (ERG11) gene of Moniliophthora perniciosa [PDF]

Genetics and Molecular Biology, 2014
The phytopathogenic fungus Moniliophthora perniciosa (Stahel) Aime & Philips-Mora, causal agent of witches' broom disease of cocoa, causes countless damage to cocoa production in Brazil.
Geruza de Oliveira Ceita, Laurival Antônio Vilas-Boas, Marcelo Santos Castilho, Marcelo Falsarella Carazzolle, Carlos Priminho Pirovani, Alessandra Selbach-Schnadelbach, Karina Peres Gramacho, Pablo Ivan Pereira Ramos, Luciana Veiga Barbosa, Gonçalo Amarante Guimarães Pereira, Aristóteles Góes-Neto   +10 more
doaj   +3 more sources

ERG11 and ABC2 Overexpression but Not ERG11 Gene Mutations Are Involved in the Development of Itraconazole Resistance in Candida Krusei

Blood, 2015
Abstract Background: Recent years, the incidence and mortality of fungal infection has been on the rise in the patients with hematologic malignancies. This is mainly associated with antifungal resistance and the restricted number of available antifungal drugs.
Xiaoyuan He, Mingfeng Zhao, Jinyan Chen, Rimao Wu, Jianlei Zhang, Rui Cui, Yanyu Jiang, Jie Chen, Xiaoli Cao, Yi Xing, Juanxia Meng, Qi Deng, Tao Sui   +12 more
openaire   +1 more source

ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection [PDF]

International Journal of Oral Science, 2018
AbstractThe hyphal development of Candida albicans (C. albicans) has been considered as an essential virulent factor for host cell damage. However, the missing link between hyphae and virulence of C. albicans is also been discovered. Here, we identified that the null mutants of ERG3 and ERG11, two key genes in ergosterol biosynthesis pathway, can form ...
Zhou, Yujie, Liao, Min, Zhu, Chengguang, Hu, Yao, Tong, Ting, Peng, Xian, Li, Mingyun, Feng, Mingye, Cheng, Lei, Ren, Biao, Zhou, Xuedong   +10 more
openaire   +2 more sources

Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients [PDF]

Current Medical Mycology, 2019
Background and Purpose: Azoles are preferred antifungal agents given their inexpensiveness, limited toxicity, and potentiality of oral administration.
Sony Paul, Iyanar Kannan, Kalyani Mohanram   +2 more
doaj   +1 more source

Synthesis of new imidazole-based ionic liquids with antifungal activity against Candida albicans

Iranian Journal of Microbiology, 2023
Background and Objectives: Candida albicans cause a problematic condition in immunocompromised patients that could not be treated quickly due to the resistant behavior of microorganisms. This study aimed to investigate the effect of a novel ionic liquid
Amir Habibi, Mansour Bayat, Behinb Omidi, Ali Ezabadi, Pejman Mortazavi   +4 more
doaj   +1 more source

Investigation of the relationship between fluconazole susceptibility, proteinase activity and ERG11-SAP2 Expression in Candida albicans strains isolated from clinical samples [PDF]

Current Medical Mycology
Background and Purpose: Candida albicans is currently recognised as an opportunistic pathogen that can cause many invasive infections. Resistance mechanisms and fungal virulence factors play an important role in the effectiveness of treatment. The aim of
Nagihan Ege, Şükrü Öksüz, Emel Akbaş, Emel Çalişkan, Mehmet Sungur   +4 more
doaj   +1 more source

CDR1, CDR2, MDR1 and ERG11 expression in azole resistant Сandida albicans isolated from HIV-infected patients in city of Moscow

Инфекция и иммунитет, 2022
Candida fungi are common opportunistic microorganisms capable of causing infections of various localization, as well as life-threatening conditions in immunocompromised patients, such as HIV-infected individuals, oncology patients, subjects undergoing ...
A. D. Voropaev, D. A. Yekaterinchev, Y. N. Urban, V. V. Zverev, Yu. V. Nesvizhsky, E. A. Voropaeva, E. I. Likhanskaya, M. S. Afanasiev, S. S. Afanasiev   +8 more
doaj   +1 more source

A Crucial Role for Ergosterol in Plasma Membrane Composition, Localisation, and Activity of Cdr1p and H⁺-ATPase in Candida albicans

Microorganisms, 2019
Candida albicans is an opportunistic fungal pathogen of humans. Treatment of C. albicans infections relies on azoles, which target the lanosterol 14α-demethylase (Erg11p) encoded by the ERG11 gene.
Jakub Suchodolski, Jakub Muraszko, Przemysław Bernat, Anna Krasowska   +3 more
doaj   +1 more source

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Microbiology Spectrum, 2021
Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers   +5 more
doaj   +1 more source

Drug Resistance-Associated Mutations in ERG11 of Multidrug-Resistant Candida auris in a Tertiary Care Hospital of Eastern Saudi Arabia

Journal of Fungi, 2020
Candida auris is an emerging multi-drug resistant pathogen with high mortality rate; nosocomial infections have been reported worldwide, causing a major challenge for clinicians and microbiological laboratories. The study aims to describe new cases of C.
Reem AlJindan, Doaa M. AlEraky, Nehal Mahmoud, Baha Abdalhamid, Mashael Almustafa, Sayed AbdulAzeez, J. Francis Borgio   +6 more
doaj   +1 more source