Results 51 to 60 of about 5,330 (202)

Resistance in Candida albicans: exploring the cell wall barrier by proteomics [PDF]

, 2015
The incidence of candidiasis has dramatically increased and bloodstream infections due to different species of Candida are becoming a prime cause of morbidity and mortality in different types of immunocompromised patients.
Angiolella, Letizia, Maras, Bruno, Mignogna, Giuseppina   +2 more
core   +1 more source

Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis [PDF]

, 2017
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds.
Ana C. A. de Paula e Silva, Ana M. Fusco-Almeida, Caroline B. Costa-Orlandi, Caroline M. Marcos, Haroldo C. de Oliveira, Liliana Scorzoni, Maria J. S. Mendes-Giannini, Patrícia A. Assato, Wanessa C. M. A. de Melo   +8 more
core   +1 more source

ERG11 mutations associated with azole resistance in Candida albicans isolates from vulvovaginal candidosis patients

Asian Pacific Journal of Tropical Biomedicine, 2015
Objective: To investigate the azole susceptibility of Candida albicans (C. albicans) from vulvovaginal candidosis patients and to analyze the relationship between ERG11 gene mutations in these isolates and azole resistance. Methods: Three hundred and two
Bin Wang, Li-Hua Huang, Ji-Xue Zhao, Man Wei, Hua Fang, Dan-Yang Wang, Hong-Fa Wang, Ji-Gang Yin, Mei Xiang   +8 more
doaj   +1 more source

Molecular epidemiology and azole resistance mechanism study of Candida guilliermondii from a Chinese surveillance system

Scientific Reports, 2017
We studied the molecular epidemiology and mechanism of azole resistance of 164 C. guilliermondii isolates from a nationwide multi-center surveillance program.
Jing-Wei Cheng, Kang Liao, Timothy Kudinha, Shu-Ying Yu, Meng Xiao, He Wang, Fanrong Kong, Ying-Chun Xu   +7 more
doaj   +1 more source

Detection of antifungal drug-resistant and ERG11 gene mutations among clinical isolates of Candida species isolated from Khartoum, Sudan. [version 2; peer review: 2 approved, 1 not approved]

F1000Research, 2021
Background: Candida species are one of the most important opportunistic fungal pathogens that cause both superficial and systemic infections, especially in immunocompromised individuals.
Ahmed Osman Mohamed, Malik Suliman Mohamed, Mohamed Abdelrahman Hussain, Ibrahim Fatahalrahman Ahmed   +3 more
doaj   +1 more source

Effect of voriconazole on Candida tropicalis biofilms: Relation with ERG genes expression [PDF]

, 2016
Candida tropicalis has emerged as the third most prevalent fungal pathogens and its ability to form biofilms has been considered one of the most important virulence factors, since biofilms represent high tolerance to antifungal agents.
C Luca De, CA Kumamoto, DW Williams, DW Williams, E Fonseca, EM Kojic, FC Bizerra, GS Baillie, KJ Livak, LJ Douglas, M Negri, M Negri, MA Al-Fattani, Mariana Henriques, NN Mishra, P Eggimann, P Muñoz, P Vandeputte, PK Mukherjee, RJ Kothavade, S Silva, S Silva, S Silva, S Silva, S Silva, SK Fridkin, SP Hawser, Sónia Silva, T Fernandes, Tânia Fernandes   +29 more
core   +1 more source

RILEVAMENTO DI SNP NEL CODONE 464 DEL GENE ERG11 IN CANDIDA ALBICANS, MEDIANTE PYROSEQUENCING

Microbiologia Medica, 2004
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ORRU, GERMANO, Ciusa M. L, Pusceddu G, Montaldo C, COSENTINO, SOFIA, PISANO, MARIA BARBARA, Meroni E, PIRAS, VINCENZO, FADDA, MARIA ELISABETTA   +8 more
openaire   +4 more sources

The combined action of ERG11 gene overexpression and its mutations in the development of Candida albicans resistance to triazolic antifungals

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Modern medicine is faced with the resistance of Candida spp. to antimycotics, due to changes in the expression and structure of the ERG11 gene, the molecular target of triazoles.
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Vitaly V. Zverev, Alexander D. Voropaev, Maxim S. Afanasiev, Elena A. Voropaeva, Elena V. Budanova, Ludmila M. Smirnova, Sofia A. Anisova, Yulia N. Urban   +9 more
doaj   +1 more source

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates

BMC Infectious Diseases, 2018
Background Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated. Methods Twenty-two C.
Longyang Jin, Zhuorui Cao, Qi Wang, Yichen Wang, Xiaojuan Wang, Hongbin Chen, Hui Wang   +6 more
doaj   +1 more source

The effects of secreted aspartyl proteinase inhibitor ritonavir on azoles‐resistant strains of Candida albicans as well as regulatory role of SAP2 and ERG11

Immunity, Inflammation and Disease, 2021
Background Candida albicans, the main human fungal pathogen, can cause fungal infection and seriously affect people's health and life. This study aimed to investigate the effects of ritonavir (RIT) on C.
Wenli Feng, Jing Yang, Yan Ma, Zhiqin Xi, Xiaoqin Zhao, Xiaoxia Zhao, Min Zhao   +6 more
doaj   +1 more source