Results 51 to 60 of about 2,525,365 (152)

Nucleotide substitutions in the Candida albicans ERG11 gene of azole-susceptible and azole-resistant clinical isolates [PDF]

, 2013
One of the mechanisms of Candida albicans resistance to azole drugs used in antifungal therapy relies on increased expression and presence of point mutations in the ERG11 gene that encodes sterol 14α demethylase (14DM), an enzyme which is the primary ...
Gołąbek, Karolina, Rother, Magdalena, Ślemp-Migiel, Anna, Strzelczyk, Joanna, Wiczkowski, Andrzej   +4 more
core  

Induced expression of Ganoderma boninense lanosterol 14α-demethylase (ERG11) during interaction with oil palm

, 2023
Background: The basidiomycete fungus, Ganoderma boninense is the main contributor to oil palm Basal Stem Rot (BSR) in Malaysia and Indonesia. Lanosterol 14α-Demethylase (ERG11) is a key enzyme involved in biosynthesis of ergosterol, which is an important
Vadamalai, Ganesan, Ahmad Parveez, Ghulam Kadir, Lim, Fook-Hwa, Abdul Wahab, Mohd As’wad, Wong, Mui-Yun, Abd Rasid, Omar, Abu Seman, Idris   +6 more
core   +1 more source

Emergence of Trichophyton indotineae in Switzerland (2014–2025): Clinical analysis and antifungal susceptibility

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Trichophyton indotineae is an emerging dermatophyte associated with chronic, recalcitrant dermatophytosis and terbinafine resistance due to squalene epoxidase (SQLE) mutations. We analyzed clinical characteristics, antifungal susceptibility profiles, SQLE mutations, and treatment outcomes of cases diagnosed in ...
Annabel H. Lechner, Dennis D. Arnold, Philipp P. Bosshard   +2 more
wiley   +1 more source

Correlation of antifungal susceptibility and sequence types within Cryptococcus neoformans VNI from HIV patients, and ERG11 gene polymorphism [PDF]

, 2023
peer reviewed[en] INTRODUCTION: Here we tested the correlation between minimum inhibitory concentrations (MICs) of major antifungal agents and sequence types (STs) within Cryptococcus neoformans VNI isolates, and explored the ERG11 gene of included ...
Rosalie Sacheli, Pius Kabututu Zakayi, Sébastien Bontems, Celestin Nzanzu Mudogo, Sacheli, Rosalie, Zakayi, Pius Kabututu, Georges Mvumbi Lelo, Bive, Bive Zono, Hayette, Marie-Pierre, Bontems, Sébastien, Bive Zono Bive, Lelo, Georges Mvumbi, Mudogo, Celestin Nzanzu, Marie-Pierre Hayette   +13 more
core   +1 more source

Comparative genomics reveals lineage‐associated structural variation and diversification in a barley fungal pathogen

New Phytologist, EarlyView.
Genome‐wide copy‐number variation landscape highlights structural divergence across Puccinia hordei isolates and potentially links Cyp51 amplification to fungicide insensitivity. Summary Leaf rust, caused by Puccinia hordei, is a major barley disease worldwide.
Xiaohui Yu, Mumta Chhetri, Mafruha Hasan, Thomas H. Roberts, Peng Zhang, Robert F. Park, Yi Ding   +6 more
wiley   +1 more source

ERG11 polymorphism in voriconazole-resistant candida tropicalis: Weak role of erg11 expression, ergosterol content, and membrane permeability

, 2021
© 2020 American Society for Microbiology. All Rights Reserved. Mutations in ERG11 were detected by gene sequencing and amino acid alignment in 18 Candida tropicalis strains with different degrees of sensitivity to voriconazole (VRC).
Navarro-Rodríguez P; López-Fernández L; Martin-Vicente A; Guarro J; Capilla J
core  

Fluconazole-resistant Candida parapsilosis complex candidemia and analysis of mutations in the ERG11 gene from Pakistan

, 2023
Background: Recent reports of the emergence of fluconazole resistance in Candida parapsilosis species complex poses a challenge, more specifically in settings where echinocandin-based treatment regime is not feasible.Objective: This study reported ...
Memon, Saba, Farooqi, Joveria, Malick, Ayesha, Ghanchi, Najia Bano, Jabeen, Kauser, Zeeshan, Mohammad, Naqvi, Syed Faheem   +6 more
core   +1 more source

The A395T Mutation in ERG11 Gene Confers Fluconazole Resistance in Candida tropicalis Causing Candidemia

, 2015
The mechanism of fluconazole resistance in Candida tropicalis is still unclear. Recently, we isolated a fluconazole-resistant strain of C. tropicalis from the blood specimen of a patient with candidemia in China. In vitro antifungal susceptibility of the
Chen, Wei, Tan, Jingwen, Li, Ruoyu, Liu, Wei, Zhang, Jinqing, Wan, Zhe, Sun, Yi   +6 more
core   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, Volume 2, Issue 3, September 2026.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Expression of Lanosterol 14-Demethylase (ERG11) Gene of Three-Drug Combinations in Candida albicans: Three-Drug Combinations in Candida albicans

, 2019
Patients with impaired immunity are at particular risk of infections with Candida albicans. Antifungal drugs such as azoles commonly used for candidiasis treatment, but drug resistance is one of the most common problems for public health. The aim of this
Alizadeh, Fahimeh, Ahmadsomali, Sahar, Khodavandi, Alireza   +2 more
core   +1 more source