Results 71 to 80 of about 3,364 (161)

Molecular mechanisms of azole resistance in Candida bloodstream isolates

BMC Infectious Diseases, 2019
Background Antifungal resistance rates are increasing. We investigated the mechanisms of azole resistance of Candida spp. bloodstream isolates obtained from a surveillance study conducted between 2012 and 2015.
Jocelyn Qi-Min Teo, Shannon Jing-Yi Lee, Ai-Ling Tan, Robyn Su-May Lim, Yiying Cai, Tze-Peng Lim, Andrea Lay-Hoon Kwa   +6 more
doaj   +1 more source

First Report of Fluconazole‐Resistant Candida parapsilosis Harbouring the G458S ERG11p Substitution in a Brazilian Hospital

Mycoses, Volume 69, Issue 3, March 2026.
ABSTRACT Background Fluconazole‐resistant Candida parapsilosis is a matter of concern. Objectives To investigate fluconazole resistance among Candida parapsilosis complex isolates from patients admitted to three Brazilian hospitals, and to characterise resistance mechanisms and clonal relatedness. Patients/Methods A total of 76 C.
Sarah Santos Gonçalves, Simone Bravim Maifrede, Eduardo Yäkel, Pedro Massaroni Peçanha, Francisco Ozório Bessa‐Neto, Rodrigo Cayô, Anderson Messias Rodrigues, Patricia Muñoz, Pilar Escribano, Jesús Guinea   +9 more
wiley   +1 more source

Biocide Response of Candida auris

Mycoses, Volume 69, Issue 3, March 2026.
ABSTRACT Candida auris is an emerging multidrug‐resistant yeast demonstrating remarkable persistence in healthcare environments, contributing to nosocomial transmission and outbreak persistence. Increasing disinfectant failure reports have raised concerns regarding infection control policies, as environmental reservoirs play central roles in its spread.
Sidre Erganis, Ali Ozturk, Elif Ayca Sahin, Ayse Kalkanci   +3 more
wiley   +1 more source

A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicans

Infection and Drug Resistance, 2022
Arome Solomon Odiba,1,2 Olanrewaju Ayodeji Durojaye,3– 5 Ifeoma Maureen Ezeonu,6 Anthony Christian Mgbeahuruike,7 Bennett Chima Nwanguma1,2 1Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, 410001, Nigeria; 2Department of Molecular Genetics and Biotechnology, University of Nigeria, Nsukka, Enugu ...
Odiba AS, Durojaye OA, Ezeonu IM, Mgbeahuruike AC, Nwanguma BC   +4 more
openaire   +1 more source

Basal expression of ERG11, MDR1 and CDR1 genes in clinical isolates of Candida albicans from Ecuador: insights into azole resistance surveillance

All Life
Introduction Candida albicans is an opportunistic pathogen linked to severe, often fatal, infections. Azoles are the first line of treatment, but its resistance has increasingly been reported worldwide.
Elisa María Sánchez-Villacreses, Juan Carlos Tapia, María José Cáceres-Valdiviezo, Gabriel Morey-León, Juan Carlos Fernández-Cadena, Derly Madeleiny Andrade-Molina   +5 more
doaj   +1 more source

RILEVAMENTO DI SNP NEL CODONE 464 DEL GENE ERG11 IN CANDIDA ALBICANS, MEDIANTE PYROSEQUENCING

Microbiologia Medica, 2004
-
ORRU, GERMANO, Ciusa M. L, Pusceddu G, Montaldo C, COSENTINO, SOFIA, PISANO, MARIA BARBARA, Meroni E, PIRAS, VINCENZO, FADDA, MARIA ELISABETTA   +8 more
openaire   +4 more sources

PWWP domain-containing protein Crf4-3 specifically modulates fungal azole susceptibility by regulating sterol C-14 demethylase ERG11

mSphere
The widespread use of azole antifungals in agriculture and clinical settings has led to serious drug resistance. Overexpression of the azole drug target 14α-demethylase ERG11 (CYP51) is the most common fungal resistance mechanism.
Pengju Yu, Shuting Ye, Mi Zhou, Long Zhang, Zhongchi Zhang, Xianyun Sun, Shaojie Li, Chengcheng Hu   +7 more
doaj   +1 more source

Molecular biological characteristics of Candida albicans strains causing recurrent vulvovaginal candidiasis with different susceptibility to antifungal drugs in vitro [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. To determine molecular biological characteristics of Candida albicans strains from patients with recurrent vulvovaginal candidiasis (RVVC) associated with the formation of resistance to azole drugs. Materials and Methods.
Venchakova V.V., Oganesyan E.G., Guseva A.O., Kovyrshin S.V., Rusetskaya E.V., Marochkovich O.A., Dolgo-Saburova Yu.V., Bogomolova T.S., Zhang F.-M., Meng Q., Vasilyeva N.V., Taraskina A.E.   +11 more
doaj   +1 more source

Insights into the structure, function, and impact of Candida albicans UPC2 gene on azole resistance; a mini-review [PDF]

Current Medical Mycology
Background and Purpose: Candidiasis is a prevalent fungal infection caused by various species of Candida, especially, C. albicans. The emergence of resistance to azole medications, which are frequently prescribed for the treatment of Candida infections ...
Akbar Hoseinnejad, Amir Hossein Mahdizade, Maryam Erfaninejad, Firoozeh Kermani, Mona Ghazanfari, Aylar Arbabi, Seyed sobhan Bahreiny, Arezoo Bozorgomid, Mojtaba Moradi, Iman Haghani, Mahdi Abastabar   +10 more
doaj   +1 more source

[Investigation of ERG11 and MRR1 Resistance Genes in Candida parapsilosis Isolates].

Mikrobiyoloji bulteni
Candida parapsilosis is an important fungal pathogen that is particularly isolated from blood cultures. In recent years, although there are regional differences between centres, resistance to fluconazole which is the most commonly preferred drug for candidemia, has increased in many regions.
Kurt, Ozge, Kuskucu, Mert Ahmet, Yazgan, Zeynep, Arslan, Nese, Aygun, Gokhan, Kucukbasmaci, Omer   +5 more
openaire   +2 more sources