Results 71 to 80 of about 2,525,365 (152)

Molecular mechanisms of azole resistance in Candida bloodstream isolates

BMC Infectious Diseases, 2019
Background Antifungal resistance rates are increasing. We investigated the mechanisms of azole resistance of Candida spp. bloodstream isolates obtained from a surveillance study conducted between 2012 and 2015.
Jocelyn Qi-Min Teo, Shannon Jing-Yi Lee, Ai-Ling Tan, Robyn Su-May Lim, Yiying Cai, Tze-Peng Lim, Andrea Lay-Hoon Kwa   +6 more
doaj   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source

Variation in the erg11 Gene from Pneumocystis jirovecii.

, 2010
The erg11 gene codes for sterol 14-demethylase (14DM), a key enzyme in sterol biosynthesis and the target for triazole antimycotic drugs. Two sterol composition phenotypes have been described in patients with pneumonia caused by P.
CONTINI, Carlo, BETTINA LUNGREN, RONALD BRUBAKER, SCOTT P. KEELY, JAMES R. STRINGER, LAURA Q. JOHNSTON, EDNA S. KANESHIRO   +6 more
core  

WC1/WC2–Sre1 Transcriptional Cascade Controls Predation and Chlamydospore Formation in the Nematode‐Trapping Fungus Arthrobotrys flagrans

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
Systematic functional characterization of all eight GATA‐type transcription factors in the nematode‐trapping fungus Arthrobotrys flagrans reveals a novel, light‐independent WC1/WC2–Sre1 transcriptional cascade that orchestrates both trap formation and chlamydospore development, providing actionable targets for engineering superior biocontrol strains ...
Yu Zhang, Jiafang Zuo, Qianfei Shi, Peiji Zhao, Hanbo Zhang, Minghe Mo, Guohong Li   +6 more
wiley   +1 more source

Advances in Wine Yeast Autolysis: Biochemical and Molecular Mechanisms, and the Release of Organic Compounds in White and Sparkling Wines—An Updated Review

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Wine yeasts play a central role in alcoholic fermentation and significantly contribute to the sensory attributes of wines through cellular autolysis during lees aging (sur lie), especially in white wines. This process releases organic compounds that alter the wine's chemical and sensory profile.
José Ricardo Machado dos Santos, Aniela Pinto Kempka   +1 more
wiley   +1 more source

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
S Eyre, J Worthington, X Ke, P Martin, W Thomson, A Hinks, E Flynn, J Packham, A Barton, Martin, P., Barton, A., Gardner-Medwin, J. [CAPS and BSPAR study groups], UKRAG Consortium, Worthington, J., Thomson, W., Flynn, E., Packham, J., Hinks, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Eyre, S., Ke, X., Childhood Arthritis Prospective Study (CAPS)   +21 more
core   +1 more source

Basal expression of ERG11, MDR1 and CDR1 genes in clinical isolates of Candida albicans from Ecuador: insights into azole resistance surveillance

All Life
Introduction Candida albicans is an opportunistic pathogen linked to severe, often fatal, infections. Azoles are the first line of treatment, but its resistance has increasingly been reported worldwide.
Elisa María Sánchez-Villacreses, Juan Carlos Tapia, María José Cáceres-Valdiviezo, Gabriel Morey-León, Juan Carlos Fernández-Cadena, Derly Madeleiny Andrade-Molina   +5 more
doaj   +1 more source

PWWP domain-containing protein Crf4-3 specifically modulates fungal azole susceptibility by regulating sterol C-14 demethylase ERG11

mSphere
The widespread use of azole antifungals in agriculture and clinical settings has led to serious drug resistance. Overexpression of the azole drug target 14α-demethylase ERG11 (CYP51) is the most common fungal resistance mechanism.
Pengju Yu, Shuting Ye, Mi Zhou, Long Zhang, Zhongchi Zhang, Xianyun Sun, Shaojie Li, Chengcheng Hu   +7 more
doaj   +1 more source

Molecular biological characteristics of Candida albicans strains causing recurrent vulvovaginal candidiasis with different susceptibility to antifungal drugs in vitro [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. To determine molecular biological characteristics of Candida albicans strains from patients with recurrent vulvovaginal candidiasis (RVVC) associated with the formation of resistance to azole drugs. Materials and Methods.
Venchakova V.V., Oganesyan E.G., Guseva A.O., Kovyrshin S.V., Rusetskaya E.V., Marochkovich O.A., Dolgo-Saburova Yu.V., Bogomolova T.S., Zhang F.-M., Meng Q., Vasilyeva N.V., Taraskina A.E.   +11 more
doaj   +1 more source

Insights into the structure, function, and impact of Candida albicans UPC2 gene on azole resistance; a mini-review [PDF]

Current Medical Mycology
Background and Purpose: Candidiasis is a prevalent fungal infection caused by various species of Candida, especially, C. albicans. The emergence of resistance to azole medications, which are frequently prescribed for the treatment of Candida infections ...
Akbar Hoseinnejad, Amir Hossein Mahdizade, Maryam Erfaninejad, Firoozeh Kermani, Mona Ghazanfari, Aylar Arbabi, Seyed sobhan Bahreiny, Arezoo Bozorgomid, Mojtaba Moradi, Iman Haghani, Mahdi Abastabar   +10 more
doaj   +1 more source