Results 81 to 90 of about 5,330 (202)

Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance‐Associated Vacuolar Sequestration in Candida Species

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Fluorescent probes derived from all three clinically used polyene antifungals (amphotericin B, nystatin, and natamycin) enabled direct visualization of distribution in yeast cells of various Candida species. While retaining the ergosterol‐dependent mode of action of their parent drugs, the probes revealed distinct, structure‐specific localization ...
Melissa Shbeta, Tal Kopp, Ivan Voronov, Adi Yona, Rania Hasib Afana, Shmuel Carmeli, Micha Fridman   +6 more
wiley   +2 more sources

African ST173 Cryptococcus deuterogattii strains are commonly less susceptible to fluconazole: An unclear mechanism of resistance

Journal of Global Antimicrobial Resistance, 2020
Objectives: Fluconazole (FCZ), either alone or in combination, is often administered for treatment of cryptococcal meningitis, especially in sub-Saharan Africa. Its extensive use has led to the emergence of FCZ-resistant strains.
S. Bertout, F. Roger, P. Drakulovski, A.S. Martin, T. Gouveia, F. Kassi, H. Menan, D. Krasteva, E. Delaporte, V. Bellet   +9 more
doaj   +1 more source

Probing the role of point mutations in the cyp51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae [PDF]

, 2017
Azole-resistant strains of Aspergillus fumigatus have been detected and the underlying molecular mechanisms of resistance characterized. Point mutations in the cyp51A gene have been proved to be related to azole resistance in A.
Alcazar-Fuoli, L., Cuenca-Estrella, M., Mellado, E., Sanglard, D.   +3 more
core  

The Epidemiology and Infection Control of Candida Auris in Shanghai

Mycoses, Volume 69, Issue 4, April 2026.
ABSTRACT Background Candida auris is a globally emerging multidrug‐resistant fungus. Its dissemination is driven by patient movement and asymptomatic carriers. However, molecular epidemiological studies linking imported cases to local strains in large metropolitan areas remain limited.
Mingjing Wei, Jian Guo, Li Li, Junhao Zhu, Yuyuan Xue, Guo Chen, Fan Yang, Wenjuan Wu, Min Zhu   +8 more
wiley   +1 more source

Oral Microbiota: Findings, Classification, Clinical Significance, and Therapeutic Interventions for Human Systemic Diseases

iMetaMed, Volume 2, Issue 1, March 2026.
Oral microbiota: findings, classification, clinical significance, and therapeutic interventions for human systemic diseases ABSTRACT The oral microbiota is an ecological community of commensal, symbiotic, and pathogenic microorganisms that colonizes the oral cavity.
Miao Zhang, Meihang Du, Wenjiang Zhang, Renhuan Huang, Wanting Li, Tongqi Li, Junping Bai, Ning Zhang, Jungang Chen, Jing Zhou, Bing Wang, Liwei An, Hideaki Kagami, Yiming Zhang   +13 more
wiley   +1 more source

Correlation of antifungal susceptibility and sequence types within Cryptococcus neoformans VNI from HIV patients, and ERG11 gene polymorphism

Journal of Medical Mycology, 2023
Here we tested the correlation between minimum inhibitory concentrations (MICs) of major antifungal agents and sequence types (STs) within Cryptococcus neoformans VNI isolates, and explored the ERG11 gene of included strains.We analysed 23 C. neoformans strains categorised into two groups according to the distribution of the ST profile in Kinshasa ...
Bive, Bive Zono, Sacheli, Rosalie, Mudogo, Celestin Nzanzu, Zakayi, Pius Kabututu, Bontems, Sébastien, Lelo, Georges Mvumbi, Hayette, Marie-Pierre   +6 more
openaire   +3 more sources

Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients [PDF]

, 2017
Objectives Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, APS-I) suffer from chronic candidosis caused mainly by Candida albicans, and repeated courses of azole antifungals have led to the development of resistance ...
Bowyer, Paul, Rautemaa, Riina, Richardson, Malcolm, Sanglard, Dominique, Saxen, Harri, Siikala, Emilia   +5 more
core  

First Report of Fluconazole‐Resistant Candida parapsilosis Harbouring the G458S ERG11p Substitution in a Brazilian Hospital

Mycoses, Volume 69, Issue 3, March 2026.
ABSTRACT Background Fluconazole‐resistant Candida parapsilosis is a matter of concern. Objectives To investigate fluconazole resistance among Candida parapsilosis complex isolates from patients admitted to three Brazilian hospitals, and to characterise resistance mechanisms and clonal relatedness. Patients/Methods A total of 76 C.
Sarah Santos Gonçalves, Simone Bravim Maifrede, Eduardo Yäkel, Pedro Massaroni Peçanha, Francisco Ozório Bessa‐Neto, Rodrigo Cayô, Anderson Messias Rodrigues, Patricia Muñoz, Pilar Escribano, Jesús Guinea   +9 more
wiley   +1 more source

Role of ERG11 and MDR1 genes in cycloheximide and multidrug resistance in Candida species

Brazilian Journal of Microbiology
Candida species are amongst the commensals of the mucosal surfaces of the human body which include the oral cavity, vagina, and intestinal mucosa. Fungal infections are on the rise worldwide. The overall burden of infections due to fungi is difficult to estimate because the majority of them remain undiagnosed.
Zill-e- Huma, Sidrah Saleem, Muhammad Imran, Syed Mohsin Raza, Kokab Jabeen, Faiqa Arshad   +5 more
openaire   +2 more sources

Non-synonymous ERG11 mutations in M. restricta and M. arunalokei: impact on azole susceptibility

Microbiology Spectrum
Malassezia are commensal lipid-dependent yeasts and opportunistic pathogens that cause superficial mycoses and systemic infection. Azole antifungals target cell wall ergosterol synthesis and are the first line of antifungal treatment.
Cheryl Leong, Wisely Chua, Cheng-Shoong Chong, Shi Mun Lee, Sebastian Maurer-Stroh, Won Hee Jung, Thomas L. Dawson   +6 more
doaj   +1 more source