Results 41 to 50 of about 2,525,365 (152)

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates

BMC Infectious Diseases, 2018
Background Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated. Methods Twenty-two C.
Longyang Jin, Zhuorui Cao, Qi Wang, Yichen Wang, Xiaojuan Wang, Hongbin Chen, Hui Wang   +6 more
doaj   +1 more source

The effects of secreted aspartyl proteinase inhibitor ritonavir on azoles‐resistant strains of Candida albicans as well as regulatory role of SAP2 and ERG11

Immunity, Inflammation and Disease, 2021
Background Candida albicans, the main human fungal pathogen, can cause fungal infection and seriously affect people's health and life. This study aimed to investigate the effects of ritonavir (RIT) on C.
Wenli Feng, Jing Yang, Yan Ma, Zhiqin Xi, Xiaoqin Zhao, Xiaoxia Zhao, Min Zhao   +6 more
doaj   +1 more source

ERG11-Mediated Azole Resistance in Candida albicans [PDF]

, 2013
Although many medically important Candida species are commensal to the gut or colonizers of the skin, these organisms have the propensity to cause disease in the event of a waning immune system.
Flowers, Stephanie Ann
core   +1 more source

Determining frequencies of fungicide resistance in Leptosphaeria maculans that render demethylation inhibitor fungicides ineffective in the field

Pest Management Science, EarlyView.
As little as 1–10% of the population is needed to be resistant for demethylation inhibitor fungicides to be rendered ineffective. Following a single round of selection, the frequency increases by more than 15% with limited fitness penalty detected when no selection is present.
Alec J McCallum, Alexander Idnurm, Stephen J Marcroft, Andrew H Ware, Elizabeth M Sheedy, Angela P Van de Wouw   +5 more
wiley   +1 more source

MOLECULAR MECHANISMS OF DRUG RESISTANCE IN CANDIDA ALBICANS: ROLE OF TRANSCRIPTION FACTORS MCM1 AND ADA2 [PDF]

, 2011
Candida albicans is an opportunistic fungal pathogen responsible for localized as well as disseminated infections. C. albicans is the most commonly isolated specie from blood cultures, accounting for over 60% of all Candida isolates. The fungistatic drug
MOGAVERO, SELENE
core  

The epidemiology of the blackleg pathogen, Leptosphaeria maculans, impacts fungicide resistance management strategies

Pest Management Science, EarlyView.
Understanding how infection timing drives disease is essential for the development of fungicide resistance management strategies. For blackleg disease of canola, all infection timings can contribute to the following generation, therefore all fungicide applications have the ability to select for resistance.
Alec J McCallum, Sean Roberts, Alexander Idnurm, Angela P Van de Wouw   +3 more
wiley   +1 more source

Phenotypic Analyses of ERG11 Gene Family

, 2013
Growth phenotypes of ERG11 gene family were observed with pNiiA-CPR mutants, null deletion mutants, and double mutants (erg11BΔ, pNiiA-ERG11A). Strains were grown on either inducing medium (AMM plus nitrate) or repressing medium (AMM plus ammonium) at 30
Wenqi Hu (273626), Anouk Breton (273628), Jeff Becker (273632), Bo Jiang (76119), Sarah Kauffman (263669), John Davison (76123), Joel Bowman (273631), Sebastien Lemieux (5650741), Chunlin Xin (273630), Terry Roemer (76128), Susan Sillaots (76124), Annie Linteau (273629)   +11 more
core   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing

BMC Microbiology, 2009
Background Amino acid substitutions in the target enzyme Erg11p of azole antifungals contribute to clinically-relevant azole resistance in Candida albicans.
Ellis David, Pantarat Namfon, McNicholas Paul, Wang Bin, Sorrell Tania C, Kong Fanrong, Wang Huiping, Xiao Meng, Widmer Fred, Chen Sharon CA   +9 more
doaj   +1 more source

Decreased DMI sensitivity of Plenodomus biglobosus (phoma of oilseed rape) associated with CYP51 substitution G476S

Pest Management Science, EarlyView.
Here, we report for the first time a target site mutation in the CYP51 gene of the oilseed rape phoma stem canker fungus Plenodomus biglobosus (Leptosphaeria biglobosa) that is associated with decreased sensitivity to sterol demethylation inhibitor fungicides.
Kevin M King, Liza M González‐Rodríguez, Joanna Kaczmarek, Małgorzata Jędryczka, Jonathan S West   +4 more
wiley   +1 more source