Results 21 to 30 of about 3,364 (161)

Fluconazole‐resistant Candida parapsilosis strains with a Y132F substitution in the ERG11 gene causing invasive infections in a neonatal unit, South Africa [PDF]

Mycoses, 2020
Olga Perovic, Nelesh Govender, Andrew Whitelaw   +2 more
exaly   +2 more sources

Azole Resistance in Candida parapsilosis From Patients With Burns in Mexico: A Genomic and Phylogenetic Analysis [PDF]

Mycoses
ABSTRACT Background Candida species are common causes of nosocomial infections. Candida parapsilosis has emerged as an important pathogen. Mortality rates associated with invasive C. parapsilosis infections range from 14.5% to 47%, with azole resistance estimated between 4% and 15%.
García‐Hernández M, Nuñez‐García L, Ortíz‐Álvarez J, Delaye‐Martínez M, Flores‐Huacuja M, Vazquez‐Olivares M, Espinosa‐Camacho L, Delgado‐Sapien G, Morales‐Espinosa M, Becerra‐Lobato N, Franco‐Cendejas R, Garza‐González E, Ostrosky‐Zeichner L, Chávez‐Heres T, Hernández‐Durán M, López‐Jácome L, Colín‐Castro C.   +16 more
europepmc   +2 more sources

A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicans. [PDF]

Infect Drug Resist, 2022
Resistance to antifungal drugs for treating Candida infections remains a major concern globally despite the range of medications available. Most of these drugs target key proteins essential to the life cycle of the organism. An enzyme essential for fungal cell membrane integrity, lanosterol 14-α demethylase (CYP51), is encoded by the ERG11 gene in ...
Odiba AS, Durojaye OA, Ezeonu IM, Mgbeahuruike AC, Nwanguma BC.   +4 more
europepmc   +4 more sources

ERG11 gene polymorphisms and susceptibility to fluconazole in Candida isolates from diabetic and kidney transplant patients [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: Candidiasis is the most frequent opportunistic mycosis in humans and can cause mortality, particularly in immunodeficient patients. One major concern is the increasing number of infections caused by drug-resistant Candidas trains, as these ...
Volmir Pitt Benedetti, Daiani Cristina Savi, Rodrigo Aluizio, Douglas Adamoski, Vanessa Kava, Lygia Vitória Galli-Terasawa, Chirlei Glienke   +6 more
doaj   +4 more sources

Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea. [PDF]

Emerg Infect Dis, 2018
We recently observed the emergence of fluconazole-resistant Candida parapsilosis bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates and persisted within hospitals for several years, as revealed by microsatellite
Choi YJ, Kim YJ, Yong D, Byun JH, Kim TS, Chang YS, Choi MJ, Byeon SA, Won EJ, Kim SH, Shin MG, Shin JH.   +11 more
europepmc   +5 more sources

Expression pattern of Drug-Resistance Genes ERG11 and TAC1 in Candida albicans Clinical Isolates

Molecular Biology Reports, 2022
Abstract Background:Candida albicans (C. albicans) is an opportunistic fungus and the most common cause of vulvovaginal candidiasis (VVC). In recent years, the use of antifungal drugs has led to the incidence of drug resistance. The purpose of this study is two fold: to determine the relationship between risk factors and antifungal resistance ...
Majid Zare-Bidaki, Anis Maleki, Nahid Ghanbarzadeh, Fatemeh Nikoomanesh   +3 more
openaire   +2 more sources

P432 Detection of erg11 gene mutation in fluconazole resistant Candida albicans isolates

Medical Mycology, 2022
Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM   Objective To determine the profile of fluconazole-resistant Candida isolates (FRCS) and the proportion of erg11 gene mutation in fluconazole-resistant C.
M.S., Sheena, Singh, Rakesh
openaire   +1 more source

Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis [PDF]

Iranian Biomedical Journal, 2017
Candida parapsilosis is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms.The antifungal susceptibility of 120 clinical C. parapsilosis isolates was examined.
Lotfali, Ensieh, Ghajari, Ali, Kordbacheh, Parivash, Zaini, Farideh, Mirhendi, Hossein, Mohammadi, Rasoul, Noorbakhsh, Fatemeh, Rezaie, Sassan   +7 more
openaire   +2 more sources

Recovery Rate of Fungal Pathogens Isolated from Cases of Bovine and Ovine Mycotic Mastitis [PDF]

Journal of Veterinary Medical Research, 2023
Investigating bovine and ovine mycotic mastitis was the study's goal. A total of 250 milk samples were collected from cows, ewes and does suffering from mastitis, not responding for antibiotic therapy, to determine the prevalence of fungal pathogens ...
Ismail Raheel, Walid Hassan, hala salam, Ahmed Abed, Shaaban Salem   +4 more
doaj   +1 more source

The Risk Factors and Mechanisms of Azole Resistance of Candida tropicalis Blood Isolates in Thailand: A Retrospective Cohort Study

Journal of Fungi, 2022
In recent decades, an epidemiological shift has been observed from Candida infections to non-albicans species and resistance to azoles. We investigated the associated factors and molecular mechanisms of azole-resistant blood isolates of C.
Teera Leepattarakit, Orawan Tulyaprawat, Popchai Ngamskulrungroj   +2 more
doaj   +1 more source