Results 11 to 20 of about 5,330 (202)

Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis

Biomédica: revista del Instituto Nacional de Salud, 2023
Introduction. Drug resistance to azoles is a growing problem in the Candida genus. Objective. To analyze molecularly the genes responsible for fluconazole resistance in Candida tropicalis strains. Materials and methods. Nineteen strains, with and without
Ana Elisa Rojas, Leidy Yurany Cárdenas, María Camila García, Jorge Enrique Pérez   +3 more
doaj   +3 more sources

ERG11 Gene Variability and Azole Susceptibility in Malassezia pachydermatis. [PDF]

Mycopathologia, 2023
AbstractMalassezia pachydermatis is part of the normal skin microbiota of various animal species but under certain circumstances becomes an opportunistic pathogen producing otitis and dermatitis. Commonly these Malassezia diseases are effectively treated using azoles. However, some cases of treatment failure have been reported. Alterations in the ERG11
Díaz L, Castellá G, Bragulat MR, Cabañes FJ.   +3 more
europepmc   +4 more sources

Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans

Current Medical Mycology, 2017
Background and Purpose: The frequency of opportunistic fungal infections in immunocompromised patients, especially by Candida species, has sharply increased in the last few decades.
Fahimeh Alizadeh, Alireza Khodavandi, Sara Zalakian   +2 more
doaj   +3 more sources

ERG11 gene polymorphisms and susceptibility to fluconazole in Candida isolates from diabetic and kidney transplant patients [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: Candidiasis is the most frequent opportunistic mycosis in humans and can cause mortality, particularly in immunodeficient patients. One major concern is the increasing number of infections caused by drug-resistant Candidas trains, as these ...
Volmir Pitt Benedetti, Daiani Cristina Savi, Rodrigo Aluizio, Douglas Adamoski, Vanessa Kava, Lygia Vitória Galli-Terasawa, Chirlei Glienke   +6 more
doaj   +4 more sources

A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicans. [PDF]

Infect Drug Resist, 2022
Resistance to antifungal drugs for treating Candida infections remains a major concern globally despite the range of medications available. Most of these drugs target key proteins essential to the life cycle of the organism. An enzyme essential for fungal cell membrane integrity, lanosterol 14-α demethylase (CYP51), is encoded by the ERG11 gene in ...
Odiba AS, Durojaye OA, Ezeonu IM, Mgbeahuruike AC, Nwanguma BC.   +4 more
europepmc   +4 more sources

Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea. [PDF]

Emerg Infect Dis, 2018
We recently observed the emergence of fluconazole-resistant Candida parapsilosis bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates and persisted within hospitals for several years, as revealed by microsatellite
Choi YJ, Kim YJ, Yong D, Byun JH, Kim TS, Chang YS, Choi MJ, Byeon SA, Won EJ, Kim SH, Shin MG, Shin JH.   +11 more
europepmc   +5 more sources

Spectrum and functional properties of ERG11 gene mutations in fluconazole-resistant Candida albicans strains isolated from HIV-infected patients

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Rationale. The low efficacy of azole antimycotics in treatment of Candida infections, especially in HIV-infected patients, is often associated with overexpression of the ERG11 gene in Candida spp., which results in increased production of ergosterol the
Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Alexander D. Voropaev, Yulia N. Urban, Mariam E. Suleimanova, Maxim S. Afanasiev, Elena V. Budanova, Elena A. Voropaeva   +7 more
doaj   +1 more source

Overexpression of Both ERG11 and ABC2 Genes Might Be Responsible for Itraconazole Resistance in Clinical Isolates of Candida krusei. [PDF]

PLoS ONE, 2015
To study the main molecular mechanisms responsible for itraconazole resistance in clinical isolates of Candida krusei.The 14α-demethylases encoded by ERG11 gene in the 16 C.krusei clinical isolates were amplified by polymerase chain reaction (PCR), and ...
Xiaoyuan He, Mingfeng Zhao, Jinyan Chen, Rimao Wu, Jianlei Zhang, Rui Cui, Yanyu Jiang, Jie Chen, Xiaoli Cao, Yi Xing, Yuchen Zhang, Juanxia Meng, Qi Deng, Tao Sui   +13 more
doaj   +1 more source

Expression pattern of Drug-Resistance Genes ERG11 and TAC1 in Candida albicans Clinical Isolates

Molecular Biology Reports, 2022
Abstract Background:Candida albicans (C. albicans) is an opportunistic fungus and the most common cause of vulvovaginal candidiasis (VVC). In recent years, the use of antifungal drugs has led to the incidence of drug resistance. The purpose of this study is two fold: to determine the relationship between risk factors and antifungal resistance ...
Majid Zare-Bidaki, Anis Maleki, Nahid Ghanbarzadeh, Fatemeh Nikoomanesh   +3 more
openaire   +2 more sources

Lack of Association between Fluconazole Susceptibility and ERG11 Nucleotide Polymorphisms in Cryptococcus neoformans Clinical Isolates from Uganda

Journal of Fungi, 2022
Fluconazole is the drug of choice for cryptococcal meningitis (CM) monoprophylaxis in resource-limited settings such as Uganda. Emerging fluconazole resistance linked to mutations in the Cryptococcus neoformansERG11 gene (CYP51) has been observed in ...
Priscilla Belbir Atim, David B. Meya, Elliot S. Gerlach, Dennis Muhanguzi, Allan Male, Benedict Kanamwanji, Kirsten Nielsen   +6 more
doaj   +1 more source