Results 141 to 150 of about 3,777 (166)

[Analysis of ERG11 gene mutation in Candida albicans].

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2007
To study the relationship between fluconazole (FCZ)-resistance of Candida albicans and the mutation of ERG11 gene encoding FCZ-targeted enzyme.Three strains of FCZ-susceptible and 10 FCZ-resistent C. albicans were isolated from the urethra, vagina, oropharynx, respiratory tract, prostate secretion and blood samples.
Ying-bin, Wang, Hong, Wang, Hui-yu, Guo, Yong-zhong, Zhao, Shen-qiu, Luo   +4 more
openaire   +1 more source

The A395T Mutation in ERG11 Gene Confers Fluconazole Resistance in Candida tropicalis Causing Candidemia

Mycopathologia, 2014
The mechanism of fluconazole resistance in Candida tropicalis is still unclear. Recently, we isolated a fluconazole-resistant strain of C. tropicalis from the blood specimen of a patient with candidemia in China. In vitro antifungal susceptibility of the isolate was determined by using CLSI M27-A3 and E-test methods. The sequence of ERG11 gene was then
Zhe Wan, Ruoyu Li, Jingwen Tan
exaly   +3 more sources

ERG11 mutations and upregulation in clinical itraconazole-resistant isolates of Candida krusei

Canadian Journal of Microbiology, 2016
To better understand the association between the ERG11 gene and drug resistance in Candida krusei, C. krusei strains were isolated from patients from January 2010 to May 2013. Susceptibility to 5-fluorocytosine (5-FC), amphotericin B (AMB), voriconazole (VRC), fluconazole (FLC), and itraconazole (ITR) were tested by broth microdilution method ...
Wenli, Feng, Jing, Yang, Yiru, Wang, Jinyu, Chen, Zhiqin, Xi, Zusha, Qiao   +5 more
openaire   +2 more sources

Variation in the erg11 Gene from Pneumocystis jirovecii.

2010
The erg11 gene codes for sterol 14-demethylase (14DM), a key enzyme in sterol biosynthesis and the target for triazole antimycotic drugs. Two sterol composition phenotypes have been described in patients with pneumonia caused by P. jirovecii; one phenotype has a much higher amount of lanosterol derivatives (C31 and C32 sterols) dominated by ...
SCOTT P. KEELY, JAMES R. STRINGER, CONTINI, Carlo, BETTINA LUNGREN, RONALD BRUBAKER, LAURA Q. JOHNSTON, EDNA S. KANESHIRO   +6 more
openaire   +1 more source

The new mutation L321F in Candida albicans ERG11 gene may be associated with fluconazole resistance

Revista Iberoamericana de Micología, 2013
For many years fluconazole has been commonly used to treat Candida infections. However, the indiscriminate use of this antimycotic therapy has favored the emergence of resistant isolates. Mutations in the ERG11 gene have been described as one of the primary mechanisms of resistance in Candida species.In this study we investigated missense mutations in ...
Vagner, Oliveira Carvalho, Thelma S, Okay, Márcia S C, Melhem, Maria, Walderez Szeszs, Gilda M B, del Negro   +4 more
openaire   +2 more sources

Azole-Resistant Alleles of ERG11 in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors

Antimicrobial Agents and Chemotherapy, 2022
Scott Moye-Rowley, Bao Gia Vu
exaly  

Detection of ERG11 Overexpression in Candida albicans isolates from environmental sources and clinical isolates treated with inhibitory and subinhibitory concentrations of fluconazole

Mycoses, 2021
Josimary Vasconcelos, Oliver Jc
exaly  

Characterization ofProtothecaCYP51/ERG11 as a possible target for therapeutic drugs

Medical Mycology, 2021
Hirotaka Sato, Lisa Nonaka, Michiaki Masuda   +2 more
exaly  

P1960 Fluconazole resistance in C. parapsilosis, no evidence for ERG11 mutation

International Journal of Antimicrobial Agents, 2007
M.A. Alkhalaf, K.J. Dodgson, E. Sarvikivi, A.R. Dodgson   +3 more
openaire   +1 more source

General hospital outbreak of invasive candidiasis due to azole-resistant Candida parapsilosis associated with an Erg11 Y132F mutation

Medical Mycology, 2021
Dora E Corzo-León, Donna Maccallum
exaly