Results 151 to 160 of about 4,848 (182)

Experimental Evolution of Pathogenic <i>Candida</i> spp.: Insights into Adaptive Processes and Evolutionary Dynamics. [PDF]

Microorganisms
Sousa G, Correia I, Bezerra AR.
europepmc   +1 more source

First Case of Bloodstream Infection by <i>Candida auris</i> (<i>Candidozyma auris</i>) Resistant to Three Major Antifungal Classes in Korea. [PDF]

Ann Lab Med
Kwon YJ, Kim HS, Kim SJ, Shin JH, Kim SH.   +4 more
europepmc   +1 more source

Relative contributions of the ERG11^VF125AL and MRR1A^N647T mutations to fluconazole resistance in Clade III Candidozyma (Candida) auris clinical isolates. [PDF]

Clin Microbiol Infect
Barker KS, Zhang Q, Peters TL, Rybak JM, Morschhäuser J, Cuomo CA, Rogers PD.   +6 more
europepmc   +1 more source

The Role of ERG11 Point Mutations in the Resistance of Candida albicans to Fluconazole in the Presence of Lactate

Pathogens, 2022
Candidiasis refers to both superficial and deep-tissue fungal infections often caused by Candida albicans. The treatment of choice for these infections is the use of azoles, such as fluconazole (FLC). However, the increased use of antifungal agents has led to the emergence of azole-resistant isolates of C. albicans. Thus, the development of alternative
Anna Krasowska, Daria Derkacz, Zofia Łapińska   +2 more
exaly   +5 more sources

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Detection of ERG11 gene in fluconazole resistant urinary candida isolates

Egyptian journal of Immunology, 2022
Candida species resistant to fluconazole and voriconazole were screened for the presence of ERG11gene by polymerase chain reaction (PCR). Also, the association of this gene with the demonstration of Candida virulence factors; biofilm formation, phospholipase and proteinases activities were studied.
Manal, El Said, Hala, Badawi, Doaa, Gamal, Dalia, Salem, Heba, Dahroug, Amira, El-Far   +5 more
openaire   +2 more sources

Lack of Association between Fluconazole Susceptibility and ERG11 Nucleotide Polymorphisms in Cryptococcus neoformans Clinical Isolates from Uganda [PDF]

Journal of Fungi (Basel, Switzerland), 2022
Fluconazole is the drug of choice for cryptococcal meningitis (CM) monoprophylaxis in resource-limited settings such as Uganda. Emerging fluconazole resistance linked to mutations in the Cryptococcus neoformans ERG11 gene (CYP51) has been observed in ...
Dennis Muhanguzi, Kirsten Nielsen
exaly   +1 more source

Cloning and characterization of the lanosterol 14α-demethylase (ERG11) gene in Cryptococcus neoformans

Biochemical and Biophysical Research Communications, 2004
The ergosterol pathway in fungal pathogens is an attractive antimicrobial target because it is unique from the major sterol (cholesterol) producing pathway in humans. Lanosterol 14alpha-demethylase is the target for a major class of antifungals, the azoles. In this study we have isolated the gene for this enzyme from Cryptococcus neoformans.
S G, Revankar, J, Fu, M G, Rinaldi, S L, Kelly, D E, Kelly, D C, Lamb, S M, Keller, B L, Wickes   +7 more
openaire   +2 more sources

ERG11 mutations and expression of resistance genes in fluconazole-resistant Candida albicans isolates

Archives of Microbiology, 2015
Azole resistance in the pathogenic yeast Candida albicans poses significant challenges for its antibiotic treatment. The conformational change of the target enzyme 14 alpha-demethylase (Erg11p) due to ERG11 gene mutations is one of the mechanisms resulting in the azole resistance.
Yonghao, Xu, Fang, Sheng, Jie, Zhao, Lamei, Chen, Chunyang, Li   +4 more
openaire   +4 more sources

Implication of efflux pumps and ERG11 genes in resistance of clinical Trichosporon asahii isolates to fluconazole

Journal of Medical Microbiology, 2021
Introduction. Trichosporon asahii has been recognized as an opportunistic agent having a limited sensitivity to antifungal treatment. Hypothesis/Gap Statement. Molecular mechanisms of azole resistance have been rarely reported for Trichosproron asahii.
S, Abbes, H, Sellami, S, Neji, H, Trabelsi, F, Makni, A, Ayadi   +5 more
openaire   +2 more sources

Upregulation of the ERG11 gene in Candida krusei by azoles.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2012
Candida species are the agents of local and systemic opportunistic infections and have become a major cause of morbidity and mortality in the last few decades. Azole resistance in Candida krusei (C. krusei) species appears to be the result of gene alterations in relation to the ergosterol biosynthesis pathway, as well as efflux pumps.
M, Tavakoli, F, Zaini, M, Kordbacheh, M, Safara, R, Raoofian, M, Heidari   +5 more
openaire   +1 more source