Results 91 to 100 of about 4,848 (182)

Structural basis for heterogeneous phenotype of ERG11 dependent Azole resistance in C.albicans clinical isolates [PDF]

SpringerPlus, 2014
Correlating antifungal Azole drug resistance and mis-sense mutations of ERG11 has been paradoxical in pathogenic yeast Candida albicans. Amino acid substitutions (single or multiple) are frequent on ERG11, a membrane bound enzyme of Ergosterol biosynthesis pathway. Presence or absence of mutations can not sufficiently predict susceptibility. To analyze
Debnath, Surajit, Addya, Soma
openaire   +2 more sources

Effects of the HDAC6/8 Inhibitor MC1568, Alone and in Combination With Fluconazole, in Non‐Albicans Candida Species Infections

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
This study explores new antifungal strategies to combat non‐albicans Candida species. We tested clinically approved HDAC inhibitors—Vorinostat, Romidepsin, Tucidinostat—and the HDAC6/8‐selective MC1568, alone and with Fluconazole. The Fluconazole/MC1568 combination significantly enhanced antifungal activity and reduced biofilm formation.
Andrea Giammarino, Chiara Lambona, Alessia Raucci, Giovanna Simonetti, Salvatore Macrì, Angela Iuzzolino, Daniela Trisciuoglio, Sergio Valente, Gustavo Giusiano, Letizia Angiolella, Antonello Mai   +10 more
wiley   +1 more source

Nucleotide substitutions in the Candida albicans ERG11 gene of azole-susceptible and azole-resistant clinical isolates [PDF]

, 2013
One of the mechanisms of Candida albicans resistance to azole drugs used in antifungal therapy relies on increased expression and presence of point mutations in the ERG11 gene that encodes sterol 14α demethylase (14DM), an enzyme which is the primary ...
Gołąbek, Karolina, Rother, Magdalena, Ślemp-Migiel, Anna, Strzelczyk, Joanna, Wiczkowski, Andrzej   +4 more
core  

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source

Expression of Lanosterol 14-Demethylase (ERG11) Gene of Three-Drug Combinations in Candida albicans: Three-Drug Combinations in Candida albicans

, 2019
Patients with impaired immunity are at particular risk of infections with Candida albicans. Antifungal drugs such as azoles commonly used for candidiasis treatment, but drug resistance is one of the most common problems for public health. The aim of this
Alizadeh, Fahimeh, Ahmadsomali, Sahar, Khodavandi, Alireza   +2 more
core   +1 more source

Dual‐Targeting, Hybrid Antifungal Agents Targeting Candida albicans—An Overview

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The selective, single‐targeting antifungal agents serve as the parent molecule(s) for the design of dual‐targeting, hybrid fungicidal agents and are discussed and compared, which enables the researchers to understand the logic for designing multi‐targeting new chemical entities (NCEs) that can exhibit dual‐sword attack on Candida albicans. ABSTRACT Due
Sarmistha Pal, Sriparna Pusti, Iftakhar Hussain Ansari, Sanchita Pradhan, Hritabrata Bhattacharya, Shuvradip Das   +5 more
wiley   +1 more source

Phenotypic Analyses of ERG11 Gene Family

, 2013
Growth phenotypes of ERG11 gene family were observed with pNiiA-CPR mutants, null deletion mutants, and double mutants (erg11BΔ, pNiiA-ERG11A). Strains were grown on either inducing medium (AMM plus nitrate) or repressing medium (AMM plus ammonium) at 30
Wenqi Hu (273626), Anouk Breton (273628), Jeff Becker (273632), Bo Jiang (76119), Sarah Kauffman (263669), John Davison (76123), Joel Bowman (273631), Sebastien Lemieux (5650741), Chunlin Xin (273630), Terry Roemer (76128), Susan Sillaots (76124), Annie Linteau (273629)   +11 more
core   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source

WC1/WC2–Sre1 Transcriptional Cascade Controls Predation and Chlamydospore Formation in the Nematode‐Trapping Fungus Arthrobotrys flagrans

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
Systematic functional characterization of all eight GATA‐type transcription factors in the nematode‐trapping fungus Arthrobotrys flagrans reveals a novel, light‐independent WC1/WC2–Sre1 transcriptional cascade that orchestrates both trap formation and chlamydospore development, providing actionable targets for engineering superior biocontrol strains ...
Yu Zhang, Jiafang Zuo, Qianfei Shi, Peiji Zhao, Hanbo Zhang, Minghe Mo, Guohong Li   +6 more
wiley   +1 more source

Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities

Nature Communications
Azole effectiveness against candidiasis can be compromised by Candida albicans resistance and tolerance, and unfortunately, few clinically useful compounds can enhance azole antifungal activities. We find that the amino acids V234, F235 and L238 of Erg11
Wanqian Li, Malcolm Whiteway, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang   +5 more
doaj   +1 more source