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The Multifunctional Fungal Ergosterol [PDF]
mBio, 2018 The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are ...
Rodrigues, Marcio L. +1 more
openaire +4 more sources
Foods, 2023 Ergosterol is an important sterol commonly found in edible mushrooms, and it has important nutritional value and pharmacological activity. Ergosterol is a provitamin.
Panthakarn Rangsinth +11 more
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Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles
Frontiers in Microbiology, 2018 Fungi transcriptionally upregulate expression of azole efflux pumps and ergosterol biosynthesis pathway genes when exposed to antifungal agents that target ergosterol biosynthesis.
Chengcheng Hu +9 more
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Engineering Yarrowia lipolytica for high-level ergosterol production [PDF]
Synthetic and Systems BiotechnologyErgosterol is the key precursor of steroid drug synthesis. In this experiment, we systematically modified the synthesis of ergosterol. Firstly, we identified key rate-limiting enzymes through systematic screening of the post-squalene pathway ...
Xinyu Liu +7 more
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Frontiers in Bioengineering and Biotechnology, 2021 Ergosterol, a terpenoid compound produced by fungi, is an economically important metabolite serving as the direct precursor of steroid drugs. Herein, ergsosterol biosynthetic pathway modification combined with storage capacity enhancement was proposed to
Zhi-Jiao Sun +8 more
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Molecules, 2023 Inflammation caused by microglial activation is important in neurodegenerative diseases. In this research, we tried to identify safe and effective anti-neuroinflammatory agents by screening a natural compounds library and found that Ergosterol can ...
Ping Sun +10 more
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Journal of Fungi, 2021 Ergosterol (ERG) is a potential target for the development of antifungal agents against Penicillium digitatum, the pathogen of green mold in citrus fruits.
Qiuli OuYang +5 more
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Determination of Optimum Conditions for Ergosterol Production by Saccharomyces cerevisiae
Maǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗ, 2022 Ergosterol is an important provitamin in the present-day of industrial biotechnology. Seven yeast strains were obtained from the market of Basrah city and subjected to screening for their ergosterol production ability using liquid-state fermentation, the
Esraa S. Ethafa, Alaa J. A. Al-Manhel
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A Mechanism by which Ergosterol Inhibits the Promotion of Bladder Carcinogenesis in Rats
Biomedicines, 2020 We previously showed that ergosterol has an inhibitory effect on bladder carcinogenesis. In this study, we aimed to elucidate the molecular mechanism by which ergosterol inhibits bladder carcinogenesis using a rat model of N-butyl-N-(4-hydroxybutyl ...
Nobutomo Ikarashi +5 more
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Ergosterol purification from basidiomes of Clouded Agaric (Clitocybe nebularis (Fr.) Kumm.)
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014 Ergosterol (ergosta-5 ,7,22-trien-3β-ol ) is a compound found only in fungi. Ergosterol has medical interest, as it is easily converted into Vitamin D2. In the previous work we have studied 22 species of true fungi. The highest quantity of ergosterol was
V. O. Antonyuk
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