Results 31 to 40 of about 22,371 (191)

Antioxidant Potential of Ergosterol–Phospholipid Liposomes with Thymus serpyllum Extract

Proceedings
The antioxidant activity of ergosterol–phospholipid liposomes with chemically characterized, encapsulated wild thyme (Thymus serpyllum) extract was examined. 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)
Dragana Dekanski, Andrea Pirković, Diana Lupulović, Predrag Petrović, Aleksandra A. Jovanović   +4 more
doaj   +1 more source

Development and Characterization of Ribes nigrum Extract‐Loaded PLGA/Chitosan Nanoparticles as a Vaginal Drug Delivery System for Vulvovaginal Candidiasis

Journal of Applied Polymer Science, EarlyView.
Ribes nigrum extract‐loaded PLGA/chitosan nanoparticles is developed as a vaginal drug delivery system for vulvovaginal candidiasis. The chitosan‐coated nanoparticles exhibit favorable physicochemical properties, strong mucoadhesion, sustained release for up to 2 weeks, excellent biocompatibility, and potent antifungal activity against Candida albicans,
Ayca Aslan Aras, Deniz Uygunoz, Emre Karaduman, Neslihan Merve Eren, Secil Gunay Avci, Mehmet Burcin Piskin, Emek Moroydor Derun   +6 more
wiley   +1 more source

Ergosterol Supplementation Improves Furfural Tolerance of Saccharomyces cerevisiae to Produce Ethanol and Its Underlying Mechanism

BioResources, 2022
Furfural produced during lignocellulose pretreatment to reduce the recalcitrance inhibits the growth of Saccharomyces cerevisiae and reduces ethanol yield. To reduce the adverse effect of furfural on S.
Youpiao Jia, Qingyan Zhang, Jun Dai, Xueyun Zheng, Xianzhi Meng, Ranran Zhou, Haitao Yang, Lan Yao, Xiong Chen   +8 more
doaj   +2 more sources

Co-culture with Lactobacillus plantarum SC-1 facilitates ergosterol synthesis in Monascus purpureus through MpSet1-affected H3K4ac establishment

Frontiers in Microbiology
IntroductionIn fungi, ergosterol synthesis is regulated by multiple transcription factors such as Upc2, but the regulation of ergosterol synthesis in Monascus remains unclear.MethodsWe performed a co-culture system of Monascus purpureus (M.
Zhongling Wu, Zhenmin Liu
doaj   +1 more source

A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

mBio, 2018
Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen Candida albicans. In vitro, C.
Kristy Koselny, Nebibe Mutlu, Annabel Y. Minard, Anuj Kumar, Damian J. Krysan, Melanie Wellington   +5 more
doaj   +1 more source

Synthesis and Cytotoxic Activity of Novel Ergosterol Peroxide Derivatives with Acrylate or Propionate Side Chain

Natural Product Communications, 2022
A series of novel ergosterol peroxide derivatives with acrylate or propionate side chain were synthesized. All compounds 3a-n were evaluated for their cytotoxicity against four kinds of human carcinoma cell lines (HepG2, MCF-7, HCT-116, and A549).
Ming Bu, Zhiguo Zhang, Gang Li, Chunhua Xie, Xiaohui Du, Guofang Ma, Hongling Li   +6 more
doaj   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates

Frontiers in Cellular and Infection Microbiology, 2017
Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C.
Yi Xu, Hua Quan, Hua Quan, Yan Wang, Hua Zhong, Jun Sun, Jianjiang Xu, Nuan Jia, Yuanying Jiang   +8 more
doaj   +1 more source

Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs. [PDF]

PLoS Pathogens, 2010
Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol biosynthesis, although the cellular basis for their antifungal activity is not understood.
Yong-Qiang Zhang, Soledad Gamarra, Guillermo Garcia-Effron, Steven Park, David S Perlin, Rajini Rao   +5 more
doaj   +1 more source

Antioxidant Properties of Ergosterol and Its Role in Yeast Resistance to Oxidation

Antioxidants, 2021
Although the functions and structural roles of sterols have been the subject of numerous studies, the reasons for the diversity of sterols in the different eukaryotic kingdoms remain unclear.
Sebastien Dupont, Paul Fleurat-Lessard, Richtier Gonçalves Cruz, Céline Lafarge, Cédric Grangeteau, Fairouz Yahou, Patricia Gerbeau-Pissot, Odonírio Abrahão Júnior, Patrick Gervais, Françoise Simon-Plas, Philippe Cayot, Laurent Beney   +11 more
doaj   +1 more source