Results 61 to 70 of about 6,332 (203)

Overexpression of efflux pump transporter genes and mutations in ERG11 pave the way to fluconazole resistance in Candida tropicalis: A study from a North India region

Journal of Global Antimicrobial Resistance, 2020
Introduction: Fluconazole resistance in Candida tropicalis health care–associated infections is increasing. We investigated the role of efflux pump and mutations in ERG11p conferring fluconazole resistance in C. tropicalis. Materials and methods: A total
Nidhi Pandey, Muktanand Tripathi, Munesh K. Gupta, Ragini Tilak   +3 more
doaj   +1 more source

Kajian Molekuler Resistensi Candida Albicans Terhadap Antifungi [PDF]

, 2014
Candida albicans is one of the species Candida which mostly cause infection in human. Antifungal agent azole, polyene, echinocandin, and flucytosine are commonly used for Candida albicans infection treatment.
Candrasari, D. S. (Damiana)
core   +3 more sources

Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14α-demethylase (ERG11) gene of Moniliophthora perniciosa [PDF]

Genetics and Molecular Biology, 2014
The phytopathogenic fungus Moniliophthora perniciosa (Stahel) Aime & Philips-Mora, causal agent of witches' broom disease of cocoa, causes countless damage to cocoa production in Brazil.
Geruza de Oliveira Ceita, Laurival Antônio Vilas-Boas, Marcelo Santos Castilho, Marcelo Falsarella Carazzolle, Carlos Priminho Pirovani, Alessandra Selbach-Schnadelbach, Karina Peres Gramacho, Pablo Ivan Pereira Ramos, Luciana Veiga Barbosa, Gonçalo Amarante Guimarães Pereira, Aristóteles Góes-Neto   +10 more
doaj   +3 more sources

Two Sequential Clinical Isolates of Candida glabrata with Multidrug-Resistance to Posaconazole and Echinocandins

Antibiotics, 2021
Candida glabrata is one of the most prevalent causative pathogens of invasive candidiasis, and multidrug-resistant strains are emerging. We identified two clinical isolates of C. glabrata, BMU10720 and BMU10722 sequentially isolated from one patient with
Qiqi Wang, Yun Li, Xuan Cai, Ruoyu Li, Bo Zheng, Ence Yang, Tianyu Liang, Xinyu Yang, Zhe Wan, Wei Liu   +9 more
doaj   +1 more source

Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis [PDF]

, 2017
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds.
Ana C. A. de Paula e Silva, Ana M. Fusco-Almeida, Caroline B. Costa-Orlandi, Caroline M. Marcos, Haroldo C. de Oliveira, Liliana Scorzoni, Maria J. S. Mendes-Giannini, Patrícia A. Assato, Wanessa C. M. A. de Melo   +8 more
core   +1 more source

A Crucial Role for Ergosterol in Plasma Membrane Composition, Localisation, and Activity of Cdr1p and H⁺-ATPase in Candida albicans

Microorganisms, 2019
Candida albicans is an opportunistic fungal pathogen of humans. Treatment of C. albicans infections relies on azoles, which target the lanosterol 14α-demethylase (Erg11p) encoded by the ERG11 gene.
Jakub Suchodolski, Jakub Muraszko, Przemysław Bernat, Anna Krasowska   +3 more
doaj   +1 more source

Effect of voriconazole on Candida tropicalis biofilms: Relation with ERG genes expression [PDF]

, 2016
Candida tropicalis has emerged as the third most prevalent fungal pathogens and its ability to form biofilms has been considered one of the most important virulence factors, since biofilms represent high tolerance to antifungal agents.
C Luca De, CA Kumamoto, DW Williams, DW Williams, E Fonseca, EM Kojic, FC Bizerra, GS Baillie, KJ Livak, LJ Douglas, M Negri, M Negri, MA Al-Fattani, Mariana Henriques, NN Mishra, P Eggimann, P Muñoz, P Vandeputte, PK Mukherjee, RJ Kothavade, S Silva, S Silva, S Silva, S Silva, S Silva, SK Fridkin, SP Hawser, Sónia Silva, T Fernandes, Tânia Fernandes   +29 more
core   +1 more source

The epidemiology of the blackleg pathogen, Leptosphaeria maculans, impacts fungicide resistance management strategies

Pest Management Science, EarlyView.
Understanding how infection timing drives disease is essential for the development of fungicide resistance management strategies. For blackleg disease of canola, all infection timings can contribute to the following generation, therefore all fungicide applications have the ability to select for resistance.
Alec J McCallum, Sean Roberts, Alexander Idnurm, Angela P Van de Wouw   +3 more
wiley   +1 more source

Candida glabrata biofilms: How far have we come? [PDF]

, 2017
Infections caused by Candida species have been increasing in the last decades and can result in local or systemic infections, with high morbidity and mortality.
Aramburu, Baillie, Baillie, Boutati, Casanova, Costa, Cowan, Czaika, Dahanukar, Dalirsani, De Bernardis, Djilani, Eteraf-Oskouei, Farahyar, Fidel, Fox, Gupta, Hazen, Helmerhorst, Kaufmann, Kikutani, Klotz, Larone, Martinez, Miranda, Nguyen, Odds, Oppenheim, Oppenheim, Ormancey, Ramage, Rodriguez-Tudela, Sardi, Sawamura, Sharanappa, van Urk, Vazquez   +36 more
core   +5 more sources

The effects of secreted aspartyl proteinase inhibitor ritonavir on azoles‐resistant strains of Candida albicans as well as regulatory role of SAP2 and ERG11

Immunity, Inflammation and Disease, 2021
Background Candida albicans, the main human fungal pathogen, can cause fungal infection and seriously affect people's health and life. This study aimed to investigate the effects of ritonavir (RIT) on C.
Wenli Feng, Jing Yang, Yan Ma, Zhiqin Xi, Xiaoqin Zhao, Xiaoxia Zhao, Min Zhao   +6 more
doaj   +1 more source