Rapid detection of ERG11 polymorphism associated azole resistance in Candida tropicalis.
PLoS ONE, 2021 Increasing reports of azole resistance in Candida tropicalis, highlight the development of rapid resistance detection techniques. Nonsynonymous mutations in the lanosterol C14 alpha-demethylase (ERG11) gene is one of the predominant mechanisms of azole ...
Saikat Paul +6 more
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Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients [PDF]
Current Medical Mycology, 2019 Background and Purpose: Azoles are preferred antifungal agents given their inexpensiveness, limited toxicity, and potentiality of oral administration.
Sony Paul +2 more
doaj +3 more sources
Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis
Biomédica: revista del Instituto Nacional de Salud, 2023 Introduction. Drug resistance to azoles is a growing problem in the Candida genus. Objective. To analyze molecularly the genes responsible for fluconazole resistance in Candida tropicalis strains. Materials and methods. Nineteen strains, with and without
Ana Elisa Rojas +3 more
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Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression [PDF]
Antimicrobial Resistance and Infection Control, 2021 Background Candida tropicalis (C. tropicalis) is an important opportunistic pathogenic Candida species that can cause nosocomial infection. In this study, we analyzed the distribution and drug susceptibility of C.
Dan Wang +5 more
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Microbiology Spectrum, 2021 Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M. Rybak +5 more
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Azole Resistance and ERG11 Mutation in Clinical Isolates of Candida tropicalis
Journal of FungiWe investigated the molecular mechanisms underlying azole resistance in seven Candida tropicalis isolates that caused candidemia and candiduria in Paraná, Brazil (2016–2022).
Adriele Celine Siqueira +10 more
doaj +2 more sources
An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence.
PLoS ONE, 2020 Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms.
Michelle L Villasmil +4 more
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First Report of Fluconazole-Resistant Candida parapsilosis Harbouring the G458S ERG11p Substitution in a Brazilian Hospital. [PDF]
MycosesABSTRACT Background Fluconazole‐resistant Candida parapsilosis is a matter of concern. Objectives To investigate fluconazole resistance among Candida parapsilosis complex isolates from patients admitted to three Brazilian hospitals, and to characterise resistance mechanisms and clonal relatedness. Patients/Methods A total of 76 C.
Gonçalves SS +9 more
europepmc +2 more sources
Universal PCR assays to detect Candida FKS and ERG11 mutations
International Journal of Infectious DiseasesIntroduction: The emergence of antifungal resistance in Candida species presents significant challenges in managing infections, particularly among immunocompromised patients.
Dr Yuk Yam Cheung +4 more
doaj +2 more sources
Non-synonymous ERG11 mutations in M. restricta and M. arunalokei: impact on azole susceptibility [PDF]
Microbiology SpectrumMalassezia are commensal lipid-dependent yeasts and opportunistic pathogens that cause superficial mycoses and systemic infection. Azole antifungals target cell wall ergosterol synthesis and are the first line of antifungal treatment.
Cheryl Leong +6 more
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