Rapid detection of ERG11 polymorphism associated azole resistance in Candida tropicalis.
PLoS ONE, 2021 Increasing reports of azole resistance in Candida tropicalis, highlight the development of rapid resistance detection techniques. Nonsynonymous mutations in the lanosterol C14 alpha-demethylase (ERG11) gene is one of the predominant mechanisms of azole ...
Saikat Paul +6 more
doaj +5 more sources
Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis [PDF]
Biomédica: revista del Instituto Nacional de Salud, 2023 Introduction. Drug resistance to azoles is a growing problem in the Candida genus. Objective. To analyze molecularly the genes responsible for fluconazole resistance in Candida tropicalis strains. Materials and methods. Nineteen strains, with and without
Ana Elisa Rojas +3 more
doaj +4 more sources
Azole Resistance and ERG11 Mutation in Clinical Isolates of Candida tropicalis
Journal of FungiWe investigated the molecular mechanisms underlying azole resistance in seven Candida tropicalis isolates that caused candidemia and candiduria in Paraná, Brazil (2016–2022).
Adriele Celine Siqueira +10 more
doaj +4 more sources
ERG11 Gene Variability and Azole Susceptibility in Malassezia pachydermatis [PDF]
Mycopathologia, 2022 AbstractMalassezia pachydermatis is part of the normal skin microbiota of various animal species but under certain circumstances becomes an opportunistic pathogen producing otitis and dermatitis. Commonly these Malassezia diseases are effectively treated using azoles. However, some cases of treatment failure have been reported. Alterations in the ERG11
Leyna Díaz +3 more
openaire +4 more sources
Universal PCR assays to detect Candida FKS and ERG11 mutations
International Journal of Infectious DiseasesIntroduction: The emergence of antifungal resistance in Candida species presents significant challenges in managing infections, particularly among immunocompromised patients.
Dr Yuk Yam Cheung +4 more
doaj +3 more sources
An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence. [PDF]
PLoS ONE, 2020 Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms.
Michelle L Villasmil +4 more
doaj +8 more sources
ERG11-Mediated Azole Resistance in Candida albicans [PDF]
, 2018 Although many medically important Candida species are commensal to the gut or colonizers of the skin, these organisms have the propensity to cause disease in the event of a waning immune system.
Flowers, Stephanie Ann
openaire +2 more sources
Overexpression of Both ERG11 and ABC2 Genes Might Be Responsible for Itraconazole Resistance in Clinical Isolates of Candida krusei. [PDF]
PLoS ONE, 2015 To study the main molecular mechanisms responsible for itraconazole resistance in clinical isolates of Candida krusei.The 14α-demethylases encoded by ERG11 gene in the 16 C.krusei clinical isolates were amplified by polymerase chain reaction (PCR), and ...
Xiaoyuan He +13 more
doaj +2 more sources
Candida tropicalis distribution and drug resistance is correlated with ERG11 and UPC2 expression [PDF]
Antimicrobial Resistance and Infection Control, 2021 Background Candida tropicalis (C. tropicalis) is an important opportunistic pathogenic Candida species that can cause nosocomial infection. In this study, we analyzed the distribution and drug susceptibility of C.
Dan Wang +5 more
doaj +4 more sources
Detection of ERG11 gene mutation in coding and non-coding regions of clinical Candida glabrata (Nakaseomyces glabratus) isolates from Pakistan [PDF]
Access MicrobiologyAzoles inhibit the cytochrome P450-dependent enzyme lanosterol 14α-demethylase (CYP51) that is encoded by the ERG11 gene. Azole resistance in Candida species arises through different mechanisms, like mutations in the ERG11 gene, ERG11 overexpression ...
Urooj Zafar +2 more
exaly +3 more sources