Results 11 to 20 of about 3,432 (131)
Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT In Candida albicans , the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in ...
Stephanie A, Flowers +4 more
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Microbiology Spectrum, 2021 Candida auris is an emerging multidrug-resistant and health care-associated pathogen of urgent clinical concern. The triazoles are the most widely prescribed antifungal agents worldwide and are commonly utilized for the treatment of invasive Candida infections.
Jeffrey M. Rybak +5 more
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ERG11 couples oxidative stress adaptation, hyphal elongation and virulence in Candida albicans [PDF]
FEMS Yeast Research, 2018 Candida albicans is a major fungal opportunistic pathogen for humans. In the treatment of C. albicans, azole drugs target the sterol 14α-demethylase (CYP51) encoded by ERG11 gene. Most studies have focused on the fact that the ERG11 mutant results in drug resistance, but its mechanism of action as a drug target has not been described yet.
YongQin, Wu +5 more
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Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion [PDF]
Antimicrobial Agents and Chemotherapy, 1996 The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase.
V L, Kan, A, Geber, J E, Bennett
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Detection of ERG11 point mutations in Iranian fluconazoleresistant Candida albicans isolates
Current Medical Mycology, 2019 Background and Purpose: Candidiasis is referred to a group of superficial anddeep-tissue fungal infections often caused by Candida albicans. The superficialinfections affect the oral, oropharynx, esophagus, and vaginal mucosa. The treatmentof choice for these infections is the use of azoles, such as fluconazole.
Ali Sardari +2 more
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Expression pattern of Drug-Resistance Genes ERG11 and TAC1 in Candida albicans Clinical Isolates
Molecular Biology Reports, 2022 Abstract Background:Candida albicans (C. albicans) is an opportunistic fungus and the most common cause of vulvovaginal candidiasis (VVC). In recent years, the use of antifungal drugs has led to the incidence of drug resistance. The purpose of this study is two fold: to determine the relationship between risk factors and antifungal resistance ...
Majid Zare-Bidaki +3 more
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Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis [PDF]
Iranian Biomedical Journal, 2017 Candida parapsilosis is one of the five common strains of yeasts involved in invasive candidiasis. The expression analysis of sterol biosynthesis pathway genes, which are associated with resistance, can assist the better understanding of antifungal resistance mechanisms.The antifungal susceptibility of 120 clinical C. parapsilosis isolates was examined.
Lotfali, Ensieh +7 more
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Novel ERG11 and TAC1b Mutations Associated with Azole Resistance in Candida auris
Antimicrobial Agents and Chemotherapy, 2021 Candida auris is a novel Candida species that has spread in all continents, causing nosocomial outbreaks of invasive candidiasis. C. auris has the ability to develop resistance to all antifungal drug classes. Notably, many C. auris isolates are resistant to
Jizhou Li +5 more
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P432 Detection of erg11 gene mutation in fluconazole resistant Candida albicans isolates
Medical Mycology, 2022 Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Objective To determine the profile of fluconazole-resistant Candida isolates (FRCS) and the proportion of erg11 gene mutation in fluconazole-resistant C.
M.S., Sheena, Singh, Rakesh
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Pest Management Science, EarlyView.As little as 1–10% of the population is needed to be resistant for demethylation inhibitor fungicides to be rendered ineffective. Following a single round of selection, the frequency increases by more than 15% with limited fitness penalty detected when no selection is present.
Alec J McCallum +5 more
wiley +1 more source