Results 31 to 40 of about 55,654 (235)

A randomized, double-blind study of amorolfine 5% nail lacquer with oral fluconazole compared with oral fluconazole alone in the treatment of fingernail onychomycosis

Indian Journal of Dermatology, 2019
Background: It is a challenge to treat onychomycosis due to frequent treatment failures and relapses. Systemic and topical therapies need to be combined to improve cure rates.
Somodyuti Chandra, Karan Sancheti, Indrashis Podder, Anupam Das, Tushar Kanti Sarkar, Moitreyee Chowdhury, Amrita Sil, Susmita Bhattacharya, Nilay Kanti Das   +8 more
doaj   +1 more source

Universal Screening of Tanzanian HIV-Infected Adult Inpatients with the Serum Cryptococcal Antigen to Improve Diagnosis and Reduce Mortality: An Operational Study. [PDF]

, 2011
Cryptococcal meningitis is a leading cause of death among HIV-infected individuals in sub-Saharan Africa. Recent developments include the availability of intravenous fluconazole, cryptococcal antigen assays and new data to support fluconazole pre-emptive
Fitzgerald, Daniel W, Wajanga, Bahati Mk, Samuel Kalluvya, Bahati MK Wajanga, Daniel W Fitzgerald, Peck, Robert N, Jennifer A Downs, Warren D Johnson, Downs, Jennifer A, Johnson, Warren D, Robert N Peck, Kalluvya, Samuel   +11 more
core   +1 more source

Treatment of experimental cryptococcal meningitis with fluconazole: impact of dose and addition of flucytosine on mycologic and pathophysiologic outcome [PDF]

, 1996
Fluconazole is effective in the therapy of cryptococcal meningitis in patients with AIDS. The optimal dosage of fluconazole and the impact of combination with flucytosine are not known.
Kartalija, M, Kaye, K, Täuber, MG, Tureen, JH, Liu, Q, Elliott, BR, Sande, MA   +6 more
core   +1 more source

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Microbiology Spectrum, 2021
Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers   +5 more
doaj   +1 more source

Development and Characterization of Ribes nigrum Extract‐Loaded PLGA/Chitosan Nanoparticles as a Vaginal Drug Delivery System for Vulvovaginal Candidiasis

Journal of Applied Polymer Science, EarlyView.
Ribes nigrum extract‐loaded PLGA/chitosan nanoparticles is developed as a vaginal drug delivery system for vulvovaginal candidiasis. The chitosan‐coated nanoparticles exhibit favorable physicochemical properties, strong mucoadhesion, sustained release for up to 2 weeks, excellent biocompatibility, and potent antifungal activity against Candida albicans,
Ayca Aslan Aras, Deniz Uygunoz, Emre Karaduman, Neslihan Merve Eren, Secil Gunay Avci, Mehmet Burcin Piskin, Emek Moroydor Derun   +6 more
wiley   +1 more source

Comparative fitness trade-offs associated with azole resistance in Candida auris clinical isolates

Heliyon
Multidrug-resistant yeast Candida auris is a serious threat to public health with documented survival in various hospital niches. The dynamics of this survival benefit and its trade off with drug resistance are still unknown for this pathogen.
Sourav Das, Shreya Singh, Yamini Tawde, Tushar K. Dutta, Shivaprakash M. Rudramurthy, Harsimran Kaur, Tushar Shaw, Anup Ghosh   +7 more
doaj   +1 more source

Serotonin reuptake inhibitors effect on fluconazole activity against resistant Candida glabrata strains

Journal of Global Antimicrobial Resistance, 2022
: Objectives: The study aimed to evaluate four selective serotonin reuptake inhibitors (SSRIs) as modifiers of fluconazole activity against resistant strains of Candida glabrata. Methods: The effect of SSRIs on fluconazole activity was studied using the
Bashar A. Alkhalifa, Nailya R. Bulatova, Waed abuRokba, Rula M. Darwish   +3 more
doaj   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Parallel evolution of fluconazole resistance and tolerance in Candida glabrata

Frontiers in Cellular and Infection Microbiology
IntroductionWith the growing population of immunocompromised individuals, opportunistic fungal pathogens pose a global health threat. Candida species, particularly C. albicans and non-albicans Candida species such as C.
Lijun Zheng, Yi Xu, Chen Wang, Yubo Dong, Liangsheng Guo   +4 more
doaj   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source