Results 11 to 20 of about 55,654 (235)

Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles [PDF]

, 2022
When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. We report the conjugation of a chiral antifungal azole pharmacophore to COX inhibitors and the evaluation of activity of ...
Pallabita Basu (12009955), Micha Fridman (1419856), Rebecca Elias (5235533)   +2 more
core   +3 more sources

A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi [PDF]

, 2013
Introduction: Cryptococcal meningitis is the most common neurological infection in HIV infected patients in Sub Saharan Africa, where gold standard treatment with intravenous amphotericin B and 5 flucytosine is often unavailable or difficult to ...
Mavuto Mukaka, Rothe, Camilla, Feasey, NA, Tom Harrison, van Oosterhout Joep J., Denis, Brigitte, Lalloo David G., Goodson, P, Rothe, C, Jean Chikafa, Sloan, DJ, Goodson, Patrick, Nicholas A Feasey, Mukaka, Mavuto, Joep J van Oosterhout, Lalloo, DG, Allain, T, Heyderman Robert S., Camilla Rothe, Harrison, T, Sloan Derek J., Harrison, Tom, Harrison Tom, Sloan, Derek J., Allain Theresa, Mukaka, M, Lalloo, David G., Theresa Allain, Goodson Patrick, Denis, B, van Oosterhout, JJ, Chikafa, Jean, Derek J Sloan, David G Lalloo, Chikafa, J, Patrick Goodson, Brigitte Denis, Rothe Camilla, Robert S Heyderman, Feasey Nicholas A., Chikafa Jean, van Oosterhout, Joep J., Mukaka Mavuto, Allain, Theresa, Feasey, Nick; id_orcid, Heyderman, RS, Feasey, Nicholas A., Denis Brigitte, Lalloo, David; id_orcid, Heyderman, Robert S.   +49 more
core   +1 more source

AMBITION-cm : intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa : study protocol for a randomized controlled trial [PDF]

, 2015
Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine, and difficulties administering 14 days of amphotericin B are key ...
Leeme, Tshepo, Síle F. Molloy, Changalucha, John M., Molefi, Mooketsi, Molloy, Síle F, Meintjes, Graeme, Molloy, Síle F., Goldberg, Drew W, John R. Perfect, Drew W. Goldberg, Kalluvya, Samuel, Cainelli, Francesca, Letang, Emili, Ndhlovu, Chiratidzo E, Perfect, John R, Ndhlovu, Chiratidzo E., Bisson, Gregory P., Miriam Haverkamp, Burton, Rosie, Rosie Burton, Tariro Makadzange, Harrison, Thomas S, Francesca Cainelli, Hope, William, Haverkamp, Miriam, Chiratidzo E. Ndhlovu, Harrison, Thomas S., Jarvis, Joseph N., Chofle, Awilly A, William Hope, Jarvis, Joseph N, Changalucha, John M, Fenner, Lukas, Perfect, John R., Makadzange, Tariro, Joseph N. Jarvis, Tshepo Leeme, Mooketsi Molefi, Nametso Lekwape, Lekwape, Nametso, John M. Changalucha, Emili Letang, Goldberg, Drew W., Lukas Fenner, Bisson, Gregory P, Awilly A. Chofle, Samuel Kalluvya, Thomas S. Harrison, Graeme Meintjes, Chofle, Awilly A., Gregory P. Bisson   +50 more
core   +1 more source

Ibuprofen-Mediated Reversal of Fluconazole Resistance in Clinical Isolates of Candida [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: In view of the increasing prevalence of invasive Candidiasis in today’s health-care scenario and the emergence of fluconazole resistance among clinical isolates of Candida, we sought to determine if Ibuprofen could elicit a reversal of ...
Monika Sharma, Debasis Biswas, Aarti Kotwal, Bhaskar Thakuria, Barnali Kakati, Bhupendra Singh Chauhan, Abhishek Patras   +6 more
doaj   +1 more source

Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study [PDF]

, 2013
Background: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. Objective: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany ...
Wissing, Heimo, Nocea, Gonzalo, Krobot, Karl J., Kaskel, Peter, Ballus, Jose, Bingold, Tobias Michael, Kumar, Ritesh N., Mavros, Panagiotis   +7 more
core   +1 more source

Fluconazole Resistance and Virulence in In Vitro Induced-Fluconazole Resistant Strains and in Clinical Fluconazole Resistant Strain of Cryptococcus deuterogattii

Pathogens, 2023
Neuromeningeal cryptococcosis is a life-threatening infection of the central nervous system, caused by encapsulated yeast belonging to the Cryptococcus neoformans and Cryptococcus gattii species complexes. Recent data showed that virulence and antifungal
Sébastien Bertout, Laetitia Laroche, Frédéric Roger, Donika Krasteva, Pascal Drakulovski, Virginie Bellet   +5 more
doaj   +1 more source

A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200 mg oral fluconazole in Blantyre, Malawi. [PDF]

, 2014
OBJECTIVE: We have previously reported high ten-week mortality from cryptococcal meningitis in Malawian adults following treatment-induction with 800 mg oral fluconazole (57% [33/58]).
Allain, TJ, Rothe, Camilla, Jassi, Chikondi, Feasey, NA, Gnanadurai, Roshina, Feasey, Nicholas A, Lalloo David G., Goodson, P, Gaskell Katherine M., Harrison Thomas S., Rothe, C, Sloan, DJ, Goodson, Patrick, Katherine M Gaskell, Nicholas A Feasey, Lalloo, DG, Heyderman Robert S., Camilla Rothe, Lalloo, David G, Sloan Derek J., Gaskell, Katherine M, Sloan, Derek J, Jassi, C, Roshina Gnanadurai, Gaskell, KM, Jassi Chikondi, Harrison, Thomas S, Sloan, Derek J., Gaskell, Katherine M., Harrison, TS, Lalloo, David G., Harrison, Thomas S., Heyderman, Robert S, Goodson Patrick, Allain Theresa J., Thomas S Harrison, Chikondi Jassi, Derek J Sloan, David G Lalloo, Gnanadurai, R, Patrick Goodson, Rothe Camilla, Robert S Heyderman, Gnanadurai Roshina, Allain, Theresa J, Feasey Nicholas A., Allain, Theresa J., Theresa J Allain, Feasey, Nick; id_orcid, Heyderman, RS, Feasey, Nicholas A., Lalloo, David; id_orcid, Heyderman, Robert S.   +52 more
core   +1 more source

Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa. [PDF]

, 2013
OBJECTIVES: Cryptococcal meningitis (CM)-related mortality may be prevented by screening patients for sub-clinical cryptococcal antigenaemia (CRAG) at antiretroviral-therapy (ART) initiation and pre-emptively treating those testing positive.
Thomas S Harrison, Wood, R, Meintjes, Graeme, Joseph N. Jarvis, Joseph N. Jarvis (435279), Harrison Thomas S., Lawn, Stephen D, Cleary, Susan, Robin Wood, Joseph N Jarvis, Stephen D Lawn, Jarvis, JN, Jarvis Joseph N., Meintjes Graeme, Thomas S. Harrison (222993), Graeme Meintjes (221054), Stephen D. Lawn (116037), Robin Wood (4924), Lawn Stephen D., Susan Cleary, Susan Cleary (158497), Stephen D. Lawn, Harrison, Thomas S, Cleary, S, Wood Robin, Harrison, TS, Thomas S. Harrison, Cleary Susan, Lawn, SD, Graeme Meintjes, Meintjes, G, Jarvis, Joseph N, Wood, Robin   +32 more
core   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal. [PDF]

, 2013
Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice.
A. Loyse, Dromer, F, Day, J, Lortholary, O, O. Lortholary, Harrison, TS, F. Dromer, Day, Jeremy, T. S. Harrison, J. Day, Loyse, A   +10 more
core   +1 more source