Pathogens, 2023 Neuromeningeal cryptococcosis is a life-threatening infection of the central nervous system, caused by encapsulated yeast belonging to the Cryptococcus neoformans and Cryptococcus gattii species complexes. Recent data showed that virulence and antifungal
Sébastien Bertout +5 more
doaj +2 more sources
Brazilian Journal of Infectious Diseases, 2016 The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and ...
Thaís Felli Kubiça +6 more
doaj +2 more sources
Emerging fluconazole resistance: Implications for the management of cryptococcal meningitis
Medical Mycology Case Reports, 2018 We present the case of an HIV-seropositive individual with cryptococcal meningitis who was found to have a fluconazole resistant strain of Cryptococcus neoformans.
Edward Mpoza, Joshua Rhein, Mahsa Abassi
doaj +2 more sources
Journal of Global Antimicrobial Resistance, 2020 Introduction: Fluconazole resistance in Candida tropicalis health care–associated infections is increasing. We investigated the role of efflux pump and mutations in ERG11p conferring fluconazole resistance in C. tropicalis. Materials and methods: A total
Nidhi Pandey +3 more
doaj +1 more source
Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study [PDF]
, 2013 Background: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. Objective: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany ...
Wissing, Heimo +7 more
core +1 more source
The assessment of therapeutic response of oropharyngeal and oesophageal candidiasis in AIDS using a new scoring system: studies with D0870. [PDF]
, 1999 We developed and compared five scoring systems designed to quantitate therapeutic response in cases of oropharyngeal candidiasis. We utilized prospectively collected data on 114 patients treated with several doses of the azole D0870.
Williams, Keith +5 more
core +3 more sources
Frontiers in Microbiology, 2022 The synergistic combinations of drugs are promising strategies to boost the effectiveness of current antifungals and thus prevent the emergence of resistance.
Ana Gaspar-Cordeiro +9 more
doaj +1 more source
A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi [PDF]
, 2013 Introduction: Cryptococcal meningitis is the most common neurological infection in HIV infected patients in Sub Saharan Africa, where gold standard treatment with intravenous amphotericin B and 5 flucytosine is often unavailable or difficult to ...
Mavuto Mukaka +50 more
core +1 more source
Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles
, 2022 When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. We report the conjugation of a chiral antifungal azole pharmacophore to COX inhibitors and the evaluation of activity of ...
Pallabita Basu (12009955) +2 more
core +2 more sources
Additivity interactions between fluconazole and citrus essential oils to Aspergillus fumigatus [PDF]
, 2021 Introduction. Aspergillus fumigatus is the most common pathogen causing allergic bronchopulmonary mycosis. The pathogenic capacity of Aspergillus fumigatus is related to its thermal tolerance and the small size of the spores which enables transfer to the
Luszczki, J. +3 more
core +1 more source