Results 41 to 50 of about 55,394 (236)

Fluconazole-resistant Candida parapsilosis: A new emerging threat in the fungi arena

Frontiers in Fungal Biology, 2022
Candida parapsilosis is a leading cause of invasive candidiasis in southern Europe, Latin America and Asia. C. parapsilosis has been mostly considered susceptible to triazoles, but fluconazole resistance is on the rise in some countries.
Pilar Escribano, Pilar Escribano, Jesús Guinea, Jesús Guinea, Jesús Guinea   +4 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrata

mSphere, 2023
Candida glabrata is a prominent opportunistic fungal pathogen of humans. The increasing incidence of C. glabrata infections is attributed to both innate and acquired resistance to antifungals.
Andrew N. Gale, Matthew W. Pavesic, Timothy J. Nickels, Zhuwei Xu, Brendan P. Cormack, Kyle W. Cunningham   +5 more
doaj   +1 more source

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, EarlyView.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source

Effectiveness of voriconazole therapy for pulmonary cryptococcosis in fluconazole treatment failure: a multicenter real-world study

BMC Infectious Diseases
Introduction Current guidelines recommend fluconazole as first-line therapy for pulmonary cryptococcosis. However, clinical reports indicate that fluconazole treatment fails in some patients.
Dian Yuan, Kang Li, Xinyu Zheng, Xiangguo Li, Yuexiang Shui, Yinghua Ying, Fugui Yan   +6 more
doaj   +1 more source

Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections

eLife, 2020
Invasive fungal infections cause 1.6 million deaths annually, primarily in immunocompromised individuals. Mortality rates are as high as 90% due to limited treatments.
Morgan A Wambaugh, Steven T Denham, Magali Ayala, Brianna Brammer, Miekan A Stonhill, Jessica CS Brown   +5 more
doaj   +1 more source

Effects of Fluconazole on the Metabolomic Profile of Candida albicans

, 2016
Background - Little is known about the effects of fluconazole on the metabolism of Candida albicans. We performed LC/MS-based metabolomic profiling of the response of C. albicans cells to increasing doses of fluconazole. Methods - C.
Katragkou, A., Alexander, E.L., Walsh, T.J., Raheem, S., Eoh, H., Roilides, E.   +5 more
core   +1 more source

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park, Yitian Zhou, Volker M. Lauschke   +2 more
wiley   +1 more source

Emerging fluconazole resistance: Implications for the management of cryptococcal meningitis

Medical Mycology Case Reports, 2018
We present the case of an HIV-seropositive individual with cryptococcal meningitis who was found to have a fluconazole resistant strain of Cryptococcus neoformans.
Edward Mpoza, Joshua Rhein, Mahsa Abassi
doaj   +1 more source

Treatment of cryptococcal meningitis in KwaZulu-Natal, South Africa. [PDF]

, 2010
BACKGROUND: Cryptococcal meningitis (CM) remains a leading cause of death for HIV-infected individuals in sub-Saharan Africa. Improved treatment strategies are needed if individuals are to benefit from the increasing availability of antiretroviral ...
Martin Dedicoat, Josephine V J Lightowler, Portia Mutevedzi, Lightowler Josephine V. J., Richard J Lessells, Newell, Marie-Louise, Marie-Louise Newell, Lightowler, Josephine VJ, Cooke, Graham S, Cooke Graham S., Mutevedzi Portia, Lessells Richard J., Mutevedzi, Portia, Lessells, Richard J, Dedicoat Martin, Dedicoat, Martin, Graham S Cooke, Newell Marie-Louise   +17 more
core   +1 more source