Results 41 to 50 of about 79,042 (238)

Antifungal activities of tacrolimus in combination with antifungal agents against fluconazole-susceptible and fluconazole-resistant Trichosporon asahii isolates

Brazilian Journal of Infectious Diseases, 2016
The antifungal activity of tacrolimus in combination with antifungal agents against different fungal species has been previously reported. Here we report the in vitro interactions between tacrolimus and amphotericin B, fluconazole, itraconazole, and ...
Thaís Felli Kubiça, Laura Bedin Denardi, Maria Isabel Azevedo, Vanessa Oliveira, Luiz Carlos Severo, Janio Morais Santurio, Sydney Hartz Alves   +6 more
doaj   +1 more source

Fluconazole resistance in non-albicans Candida species in the United States, 2012-2021

Antimicrobial Stewardship & Healthcare Epidemiology, 2023
Background: Candida spp can cause a variety of infections known as candidiasis, ranging from severe invasive infections to superficial mucosal infections of the mouth and vagina.
Emily Jenkins, Meghan Lyman, Brendan Jackson, Shawn Lockhart, Hannah Wolford, Sujan Reddy, James Baggs   +6 more
doaj   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

Comparative fitness trade-offs associated with azole resistance in Candida auris clinical isolates

Heliyon
Multidrug-resistant yeast Candida auris is a serious threat to public health with documented survival in various hospital niches. The dynamics of this survival benefit and its trade off with drug resistance are still unknown for this pathogen.
Sourav Das, Shreya Singh, Yamini Tawde, Tushar K. Dutta, Shivaprakash M. Rudramurthy, Harsimran Kaur, Tushar Shaw, Anup Ghosh   +7 more
doaj   +1 more source

The transcription factor Rpn4 activates its own transcription and induces efflux pump expression to confer fluconazole resistance in Candida auris

mBio, 2023
The emergence and nosocomial spread of the multidrug-resistant Candida auris pose a severe public health threat. Most C. auris clinical isolates are fluconazole resistant.
Eve W. L. Chow, Yabing Song, Jinxin Chen, Xiaoli Xu, Jianbin Wang, Kun Chen, Jiaxin Gao, Yue Wang   +7 more
doaj   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

Effectiveness of voriconazole therapy for pulmonary cryptococcosis in fluconazole treatment failure: a multicenter real-world study

BMC Infectious Diseases
Introduction Current guidelines recommend fluconazole as first-line therapy for pulmonary cryptococcosis. However, clinical reports indicate that fluconazole treatment fails in some patients.
Dian Yuan, Kang Li, Xinyu Zheng, Xiangguo Li, Yuexiang Shui, Yinghua Ying, Fugui Yan   +6 more
doaj   +1 more source

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, EarlyView.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source

Cytotoxicity of fluconazole on canine dental pulp-derived stem cells

Journal of Oral Biology and Craniofacial Research, 2020
Objective: In order to use fluconazole as an antifungal in cell cultures, we evaluated its possible cytotoxic effects and its influence on the proliferation and viability of canine dental pulp-derived stem cells (cDPSCs).
Paulo Henrique Utumi, Letícia Fracaro, Felipe Yukio Ishikawa Fragoso, Dayane Mayumi Miyasaki, Paula Joly dos Santos, Lidiane Maria Boldrini-Leite, Paulo Roberto Slud Brofman, José Ademar Villanova, Jr., Alexandra Cristina Senegaglia   +8 more
doaj   +1 more source

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park, Yitian Zhou, Volker M. Lauschke   +2 more
wiley   +1 more source