Results 51 to 60 of about 55,394 (236)

Impact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 and CYP3A4 contribute to clopidogrel bioactivation. CYP2C19 no‐function alleles diminish clopidogrel's antiplatelet effects and clinical effectiveness. Coadministration of either a CYP2C19 or a CYP3A4 inhibitor may also reduce clopidogrel's antiplatelet effects and lead to phenoconversion in patients without a CYP2C19 no‐function allele (normal/
Danwei Shao, Jean G. Malavé, Joseph S. Rossi, Francesco Franchi, Ellen C. Keeley, Dominick J. Angiolillo, George A. Stouffer, Larisa H. Cavallari, Craig R. Lee   +8 more
wiley   +1 more source

SWL-1 Reverses Fluconazole Resistance in Candida albicans by Regulating the Glycolytic Pathway

Frontiers in Microbiology, 2020
Candida albicans is a ubiquitous clinical fungal pathogen. Prolonged use of the first-line antifungal agent fluconazole (FLC) has intensified fungal resistance and limited its effectiveness for the treatment of fungal infections.
Xiao-Ning Li, Xiao-Ning Li, Lu-Mei Zhang, Lu-Mei Zhang, Yuan-Yuan Wang, Yi Zhang, Yi Zhang, Ze-Hua Jin, Ze-Hua Jin, Jun Li, Jun Li, Rui-Rui Wang, Rui-Rui Wang, Wei-Lie Xiao   +13 more
doaj   +1 more source

The transcription factor Rpn4 activates its own transcription and induces efflux pump expression to confer fluconazole resistance in Candida auris

mBio, 2023
The emergence and nosocomial spread of the multidrug-resistant Candida auris pose a severe public health threat. Most C. auris clinical isolates are fluconazole resistant.
Eve W. L. Chow, Yabing Song, Jinxin Chen, Xiaoli Xu, Jianbin Wang, Kun Chen, Jiaxin Gao, Yue Wang   +7 more
doaj   +1 more source

Unlocking the Multifunctional Properties of Litsea cubeba Essential Oil: Composition, Antimicrobial, Antibiofilm and Insecticidal Activities

Flavour and Fragrance Journal, EarlyView.
Unveiling the chemical and biological properties of Litsea cubeba essential oil. ABSTRACT Litsea cubeba essential oil (LCEO) is recognised for its broad spectrum of biological activities, including antimicrobial and insecticidal effects, making it a promising natural alternative to synthetic agents.
Miroslava Kačániová, Minhang Qiao, Alessandro Bianchi, Joel Horacio Elizondo‐Luevano, Anis Ben Hsouna, Rania Ben Saad, Zhaojun Ban, Li Li, Jian Lou, Wissem Mnif, Stefania Garzoli   +10 more
wiley   +1 more source

Multifunctional Properties of Wintergreen (Gaultheria procumbens) Essential Oil: Antimicrobial, Antibiofilm, and Insecticidal Effects

Flavour and Fragrance Journal, EarlyView.
Unveiling the potential of Wintergreen (Gaultheria procumbens) essential oil. ABSTRACT This study investigated the antimicrobial, antibiofilm, and insecticidal properties of wintergreen (Gaultheria procumbens L.) essential oil (GPEO). The EO was chemically characterized by GC–MS, confirming methyl salicylate as the predominant compound (99.3%).
Miroslava Kačániová, Minhang Qiao, Alessandro Bianchi, Joel Horacio Elizondo‐Luevano, Anis Ben Hsouna, Rania Ben Saad, Zhaojun Ban, Li Li, Jian Lou, Wissem Mnif, Stefania Garzoli   +10 more
wiley   +1 more source

Frequent premature ventricular contractions induced by fluconazole: A case report

IDCases
Introduction: Fluconazole is commonly used to treat and prevent fungal infections caused by Candida and Cryptococcus species. Although there have been reports of fatal arrhythmias induced by fluconazole, such as torsades de pointes, there have been ...
Kumi Tamura, Kazuhiko Nakaharai, Masaki Yoshida   +2 more
doaj   +1 more source

Cytotoxicity of fluconazole on canine dental pulp-derived stem cells

Journal of Oral Biology and Craniofacial Research, 2020
Objective: In order to use fluconazole as an antifungal in cell cultures, we evaluated its possible cytotoxic effects and its influence on the proliferation and viability of canine dental pulp-derived stem cells (cDPSCs).
Paulo Henrique Utumi, Letícia Fracaro, Felipe Yukio Ishikawa Fragoso, Dayane Mayumi Miyasaki, Paula Joly dos Santos, Lidiane Maria Boldrini-Leite, Paulo Roberto Slud Brofman, José Ademar Villanova, Jr., Alexandra Cristina Senegaglia   +8 more
doaj   +1 more source

Cost-utility analysis of caspofungin and fluconazole for primary treatment of invasive candidiasis and candidemia in Ethiopia

, 2022
BACKGROUND: Invasive candidiasis and/or candidemia (IC/C) is a common fungal infection leading to significant health and economic losses worldwide. Caspofungin was shown to be more effective than fluconazole in treating inpatients with IC/C.
Fentie, Atalay Mulu, Ali, Eskinder Eshetu, Alemayehu, Tinsae, Gebretekle, Gebremedhin Beedemariam, Gebremariam, Girma Tekle, Abebe, Workeabeba, Erku, Daniel Asfaw, Sander, Beate   +7 more
core   +1 more source

Oral Cryptococcosis due to Naganishia diffluens in a Patient With Thalassemia: A Case Report and a Literature Review

Journal of Clinical Laboratory Analysis, EarlyView.
Naganishia diffluens, a rare non‐neoformans cryptococcal species, was identified by PCR sequencing as the causative agent of oral cryptococcosis in a 31‐year‐old Iranian man with β‐thalassemia. This case represents the first documented instance of oral infection by N.
Zahra Yahyazadeh, Zeynab Haseli, Javad Javidnia, Mahdi Abastabar, Eisa Nazar, Hosein Jalali, Mohamad Taghi Hedayati, Hossein Karami, Mohsen Nosratabadi, Lotfollah Davoodi, Seyyed Reza Aghili, Maryam Moazeni, Iman Haghani, Hamid Badali   +13 more
wiley   +1 more source

Fluconazole Resistant Oral Candidiasis on HIV Patient - What Other Drug can We Choose? A Case Report [PDF]

, 2020
The majority of HIV / AIDS patients have common secondary infections including of oral candidiasis. Fluconazole can be used to treat oral resistance in candidiasis. Management that can reduce risk can be minimized.
Dwi Murtiastutik, Indah Setyawati Tantular, Cita Rosita Sigit Prakoeswa, Indah Setiawati Tantular, Cita Rosita Prakoeswa   +4 more
core   +1 more source