Results 51 to 60 of about 34,899 (249)

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Adsorption of imidazole on Au(111) surface: Dispersion corrected density functional study [PDF]

, 2016
We use density functional theory in the generalized gradient approximation to study the adsorption of imidazole on the Au(111) surface and account for dispersion effect using Grimme's empirical dispersion correction technique.
Abou El Makarim, Hassna, Benoit, David M., Izzaouihda, Safia, Komiha, Najia, Mahjoubi, Khaled   +4 more
core   +2 more sources

Janus‐Type Electrostatic Potential Gradient‐Activated Dynamic Zn2+‐Coordinating Nitrogen Sites in Molecularly Locked Nanocellulose Separators for Stable Zinc‐Ion Batteries

Advanced Science, EarlyView.
A multifunctional benzimidazole‐terminated CNF separator is constructed via a PEI‐mediated covalent locking strategy, generating dense zincophilic sites that accelerate Zn2+ transport and desolvation while enabling uniform Zn (002) deposition and suppressing side reactions.
Jie Liang, Shuxin Yang, Shuaiqi Zhao, Haitao Yang, Jingyuan Li, Jiaming Dong, Junwen Duan, Hao Yang, Yue Li, Yaxin Wang, Meilin Li, Ying Liu, Zhitao Shen, Rong Liu, Ruirui Cao, Fumin Li, Minshen Zhu, Yang Huang   +17 more
wiley   +1 more source

Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection [PDF]

, 2019
Background: In the Kingdom of Saudi Arabia (KSA), Leishmania major and L. tropica are the main causative agents of Old World cutaneous leishmaniasis (CL).
Acosta-Serrano, Álvaro, Al-Salem, Waleed S., Al-Shahrani, Ali M., Alraey, Yasser, Alsohibany, Khalid S., Alyamani, Essam J., Alzahrani, Mohamed H., Alzeyadi, Zeyad, Assiri, Abdullah M., Balghonaim, Salah M., Casas-Sánchez, Aitor, Dyer, Naomi A., Halliday, Alice, Kelly-Hope, Louise, Memish, Ziad, Solórzano, Carla, Weedall, Gareth D.   +16 more
core   +9 more sources

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Benzotriazole is antiestrogenic in vitro but not in vivo [PDF]

, 2007
Copyright © 2007 SETAC. This is the accepted version of the following article: Harris et al (2007), "Benzotriazole is antiestrogenic in vitro but not in vivo", Environmental Toxicology and Chemistry, 26(11), 2367–2372, which has been published in final ...
Brian, JV, Giger, W, Harris, CA, Routledge, EJ, Schaffner, C, Sumpter, JP   +5 more
core   +1 more source

Clotrimazole‐loaded PLGA microparticles for local drug delivery to the vagina: Shape does matter

Animal Models and Experimental Medicine, EarlyView.
Clotrimazole‐loaded PLGA microparticles for intravaginal delivery. Abstract Background Intravaginal drug administration is the most promising strategy for treating vaginal infections to protect women's health, such as vulvovaginal candidiasis (VVC). However, conventional vaginal formulations in the clinic face challenges such as drug leakage and low ...
Yanyu Li, Jingting Luo, Shitao Zou, Xin Zhang, Zhen Wang, Ziwen Jiang, Jingjie Wang, Zhaoxia Liu, Zhimin Zhou   +8 more
wiley   +1 more source

Experimenteller Nachweis der metallbezogenen Funktion eines Cyanobactins

Angewandte Chemie, EarlyView.
Patellamide (Cyanobactine) werden von einer cyanobakteriellen Spezies in grosser Menge hergestellt. Diese zyklischen Peptide wurden in der Vergangenheit fast ausschliesslich auf ihre cytotoxischen Eigenschaften untersucht. Wir diskutieren neue experimentelle Daten, die auf eine Metallionen‐abhängige biologische Funktion der Patellamide schliessen ...
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source

Synergistic Anti-Candida Activity of Bengazole A in the Presence of Bengamide A †. [PDF]

, 2019
Bengazoles A⁻G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture and ...
Cheng, Tina, Jamison, Matthew T, Molinski, Tadeusz F, Wang, Xiao   +3 more
core  

Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study [PDF]

, 2013
Background: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. Objective: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany ...
Ballus, Jose, Bingold, Tobias Michael, Kaskel, Peter, Krobot, Karl J., Kumar, Ritesh N., Mavros, Panagiotis, Nocea, Gonzalo, Wissing, Heimo   +7 more
core   +1 more source