Results 51 to 60 of about 23,046 (254)

Impact of concomitant azoles on ruxolitinib treatment in patients with GVHD: post hoc analyses of REACH2 and REACH3

Blood Advances
: Azole antifungal agents, commonly used for preventing invasive fungal infections in graft-versus-host disease (GVHD), are known to affect ruxolitinib metabolism.
Zahra Mahmoudjafari, Emily Kintsch, Zhenyi Xue, Valkal Bhatt, John Galvin, Franco Locatelli, Robert Zeiser   +6 more
doaj   +1 more source

Palladium-catalyzed desulfitative arylation of azoles with arylsulfonyl hydrazides

, 2012
Palladium-catalyzed desulfitative and denitrogenative arylation of azoles with arylsulfonyl hydrazides has been achieved. A broad scope of azoles and arylsulfonyl hydrazides has been used to produce arylated azoles in high ...
Wan, Boshun, Yu, Xinzhang, Li, Xingwei
core   +1 more source

Janus‐Type Electrostatic Potential Gradient‐Activated Dynamic Zn2+‐Coordinating Nitrogen Sites in Molecularly Locked Nanocellulose Separators for Stable Zinc‐Ion Batteries

Advanced Science, EarlyView.
A multifunctional benzimidazole‐terminated CNF separator is constructed via a PEI‐mediated covalent locking strategy, generating dense zincophilic sites that accelerate Zn2+ transport and desolvation while enabling uniform Zn (002) deposition and suppressing side reactions.
Jie Liang, Shuxin Yang, Shuaiqi Zhao, Haitao Yang, Jingyuan Li, Jiaming Dong, Junwen Duan, Hao Yang, Yue Li, Yaxin Wang, Meilin Li, Ying Liu, Zhitao Shen, Rong Liu, Ruirui Cao, Fumin Li, Minshen Zhu, Yang Huang   +17 more
wiley   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

One-pot synthesis of benzofused heteroaryl azoles via tandem C-heteroatom coupling/C–H activation of azoles

, 2011
The Cu(i) or Pd(ii)-catalyzed cross-couplings of gem-dihaloolefins with azoles via tandem C-heteroatom coupling/C–H activation for the preparation of benzofused heteroaryl azoles have been developed.
Jingsong You, Xurong Qin, Jingbo Lan, Dongbing Zhao, Xuefeng Cong   +4 more
core   +1 more source

Experimenteller Nachweis der metallbezogenen Funktion eines Cyanobactins

Angewandte Chemie, EarlyView.
Patellamide (Cyanobactine) werden von einer cyanobakteriellen Spezies in grosser Menge hergestellt. Diese zyklischen Peptide wurden in der Vergangenheit fast ausschliesslich auf ihre cytotoxischen Eigenschaften untersucht. Wir diskutieren neue experimentelle Daten, die auf eine Metallionen‐abhängige biologische Funktion der Patellamide schliessen ...
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Azoles

, 2014
Capítulo cuarto del temario del segundo bloque de la asignatura Ampliación de Química Orgánica Avanzada. Azoles.
Raoul Herbrecht, Yasmine Nivoix
openaire   +3 more sources