Results 51 to 60 of about 7,725 (230)
Animal Research and One Health, EarlyView.This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen +2 more
wiley +1 more source
Eficacia de los azoles en el tratamiento de la leishmaniasis cutánea
, 2016 Introduction: standard treatment of cutaneous leishmaniasis has many limitations associated with adverse effects, contraindications and high cost, for this reason have been explored other therapeutic options as the azole compounds.
Cardona Arias, Jaiberth Antonio +3 more
core +1 more source
Electrochemical N-olefination for the regio- and stereo-selective synthesis of vinyl azoles
Green Synthesis and CatalysisA selenium-catalyzed electrosynthesis involving regio- and stereo-selective N-olefination of azoles was developed. The room-temperature reaction was efficient (up to 97 % yield) and compatible with various styrenes and azoles.
Kejun Lin +3 more
doaj +1 more source
Susceptibility of Mexican isolates of yeasts and moulds to amphotericin B and triazole antifungals
Journal of Infection in Developing Countries, 2009 Background: Resistance to antifungal drugs, especially towards triazoles, is commonly referred to by clinicians, but data on its prevalence in developing countries is limited.
José Luis Arredondo-García +2 more
doaj +1 more source
Cooperative Phosphine-Photoredox Catalysis Enables N–H Activation of Azoles for Intermolecular Olefin Hydroamination [PDF]
Catalytic intermolecular olefin hydroamination is an enabling synthetic strategy that offers direct and atom-economical access to a variety of nitrogen-containing compounds from abundant feedstocks.
Abigail, Doyle +3 more
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
, 2017 A simple and efficient synthesis of 2-substituted azoles by alkylation of azoles with dicumyl peroxide, methylarenes and cycloalkanes under metal-free condition has been developed.
Li-kun Jin, Chun Cai, Ze-lin Li
core +1 more source
BMEMat, EarlyView.Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang +13 more
wiley +1 more source
A Review of Antifungals and their Mono- and Combination- therapy in the Treatment of Invasive Fungal Infections [PDF]
Journal of Kerman University of Medical Sciences, 2016 Invasive fungal infections with high mortality rate are a growing health concern in hospitals and medical centers. The infection usually occurs in people with compromised immune systems.
Amir Arastefar, Parisa Badiee
doaj
N‑Trifluoropropylation of Azoles through N‑Vinylation and Sequential Hydrogenation
, 2022 Installing a fluoroalkyl group onto the nitrogen atom of azoles represents a potential strategy for lead optimization in medicinal chemistry. Herein, we describe a method for the N-trifluoropropylation of azoles.
Guo-Shu Chen (8736579) +6 more
core +1 more source