Results 21 to 30 of about 23,046 (254)
Épidémiologie des candidoses systémiques dans les services à haut risque au CHU et au centre anti cancer de Batna –Algérie. [PDF]
Batna Journal of Medical Sciences, 2022 Background: Systemic candidiasis are serious conditions responsible for high mortality. The objective of this work is to describe the epidemiology of systemic candidiasis in high-risk departments at the UHC and the ACC of BATNA. Patients and methods:
Ouanassa Hamouda, Allaoua Hichem Fendri
doaj +1 more source
Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes
eLife, 2020 The mechanisms underlying resistance of the Chagas disease parasite, Trypanosoma cruzi, to current therapies are not well understood, including the role of metabolic heterogeneity.
Peter C Dumoulin +4 more
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Nature Communications, 2022 1,2-Azoles are privileged structures in many natural products and drugs. The authors report an atroposelective synthesis of two types of axially chiral 1,2-azoles, through vinylidene ortho-quinone methide intermediates.
Yu Chang +6 more
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Frontiers in Cellular and Infection Microbiology, 2022 Scedosporium and Lomentospora infections in humans are generally chronic and stubborn. The use of azoles alone cannot usually inhibit the growth of these fungi.
Zikuo Wang +5 more
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Frontiers in Toxicology, 2022 Azoles are antifungal agents used in both agriculture and medicine. They typically target the CYP51 enzyme in fungi and, by so doing, disrupt cell membrane integrity. However, azoles can also target various CYP enzymes in mammals, including humans, which
Monica Kam Draskau, Terje Svingen
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Thoracic Cancer, 2023 Background Lenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a variety of solid tumors. This study aims to investigate the potential pharmacokinetic interactions between lenvatinib and various azoles (ketoconazole ...
Mengming Xia +9 more
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Emergence and Genomic Characterization of Multidrug Resistant Candida auris in Nigeria, West Africa
Journal of Fungi, 2022 Candida auris is an emerging multidrug-resistant fungal pathogen that has become a worldwide public health threat due to the limitations of treatment options, difficulty in diagnosis, and its potential for clonal transmission.
Rita Oladele +5 more
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Emerging Trends in the Use of Topical Antifungal-Corticosteroid Combinations
Journal of Fungi, 2022 A broad range of topical antifungal formulations containing miconazole or terbinafine as actives are commonly used as efficacious choices for combating fungal skin infections.
Dalibor Mijaljica +2 more
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Platinum and gold catalysis: à la carte hydroamination of terminal activated allenes with azoles [PDF]
, 2019 Nucleophilic additions to allenes catalyzed by transition metals represent a powerful tool to get selective access to diverse structures with numerous applications. Reported here is a straightforward methodology to achieve selective addition of azoles to
Alonso, José Miguel +3 more
core +1 more source
Bioorganic & Medicinal Chemistry Letters, 2010 The plant growth-retardant uniconazole (UNI), a triazole inhibitor of gibberellin biosynthetic enzyme (CYP701A), inhibits multiple P450 enzymes including ABA 8'-hydroxylase (CYP707A), a key enzyme in ABA catabolism. Azole P450 inhibitors bind to a P450 active site by both coordinating to the heme-iron atom via sp2 nitrogen and interacting with ...
Yasushi, Todoroki +6 more
openaire +2 more sources