Aspiring Antifungals: Review of Current Antifungal Pipeline Developments
Journal of Fungi, 2020 Invasive fungal infections are associated with significant morbidity and mortality, and their management is restricted to a variety of agents from five established classes of antifungal medication.
Thomas J. Gintjee +2 more
doaj +1 more source
Use of antifungal drugs in hematology
Revista Brasileira de Hematologia e Hemoterapia, 2012 Invasive fungal disease represents a major complication in hematological patients. Antifungal agents are frequently used in hematologic patients for different purposes.
Marcio Nucci
doaj +1 more source
Variability in antifungal and antiviral use in hospitalized children [PDF]
, 2017 We analyzed antifungal and antiviral prescribing among high-risk children across freestanding children’s hospitals. Antifungal and antiviral days of therapy varied across hospitals.
Gerber, Jeffrey S +6 more
core +2 more sources
Gaining insights from Candida biofilm heterogeneity: one size does not fit all [PDF]
, 2018 Despite their clinical significance and substantial human health burden, fungal infections remain relatively under-appreciated. The widespread overuse of antibiotics and the increasing requirement for indwelling medical devices provides an opportunistic ...
Delaney, Christopher +8 more
core +8 more sources
Pediatric antifungal agents [PDF]
Current Opinion in Infectious Diseases, 2009 In immunocompromised hosts, invasive fungal infections are common and fatal. In the past decade, the antifungal armamentarium against invasive mycoses has expanded greatly. The purpose of the present report is to review the most recent literature addressing the use of antifungal agents in children.Most studies evaluating the safety and efficacy of ...
Michael, Cohen-Wolkowiez +3 more
openaire +2 more sources
Antimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp [PDF]
, 2016 The limited arsenal of synthetic antifungal agents and the emergence of resistant Candida strains have prompted the researchers towards the investigation of naturally occurring compounds or their semisynthetic derivatives in order to propose new ...
ANGIOLELLA, Letizia +4 more
core +2 more sources
Voriconazole treatment of Candida tropicalis meningitis: persistence of (1,3)-b-D-glucan in the cerebrospinal fluid is a marker of clinical and microbiological failure [PDF]
, 2016 Introduction: Infections are still the most common complications of cerebral shunt procedures. Even though fungal etiologies are considered to be rare, they are associated with significant morbidity and mortality.
Brunetti, Grazia +7 more
core +7 more sources
Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents [PDF]
, 2019 A new series of simplified azasordarin analogs was synthesized using as key steps a Diels–Alder reaction to generate a highly substituted bicyclo[2.2.1]heptane core, followed by a subsequent nitrile alkylation.
Dockendorff, Chris, Wu, Yibiao
core +4 more sources
Cyclic imide derivatives: As promising scaffold for the synthesis of antimicrobial agents
Journal of Research in Medical Sciences, 2018 Cyclic imides as building blocks in the synthesis of natural products, drugs and polymers display a diverse of pharmacological activities such as antibacterial, antifungal, anticonvulsant, anticancer, and anti-inflammatory effects. This review summarizes
Farshid Hassanzadeh, Elham Jafari
doaj +1 more source
Biogenic silver nanoparticles as antifungal agents
Frontiers in Chemistry, 2022 In recent years, an increase in multidrug-resistant fungal strains has been observed, which, together with the limited number of clinically available antifungal agents, highlights the need for the development of new antifungal agents.
Javier Mussin, Gustavo Giusiano
doaj +1 more source