Flucytosine and its clinical usage [PDF]
Therapeutic Advances in Infectious Disease, 2023 Flucytosine is an antifungal agent first licensed in the 1970’s. However, its clinical value has long been overlooked and its availability across the globe is limited.
David Denning, Shamithra Sigera
exaly +3 more sources
New Mechanisms of Flucytosine Resistance in C. glabrata Unveiled by a Chemogenomics Analysis in S. cerevisiae. [PDF]
PLoS ONE, 2015 5-Flucytosine is currently used as an antifungal drug in combination therapy, but fungal pathogens are rapidly able to develop resistance against this drug, compromising its therapeutic action. The understanding of the underlying resistance mechanisms is
Catarina Costa +7 more
doaj +3 more sources
Fluconazole plus flucytosine versus fluconazole alone for adults with HIV-associated cryptococcal antigenaemia identified through screening: a multi-centre phase III randomised-controlled trial [PDF]
TrialsBackground Despite the expansion of antiretroviral treatment programmes, the incidence and mortality of HIV-associated cryptococcal meningitis remain high in Africa. Cryptococcal antigen (CrAg) in the blood precedes meningitis.
Kyla Murphy +27 more
doaj +2 more sources
Antifungal Susceptibility of Clinical Meyerozyma guillermondii Isolates Obtained Between 1994 and 2014: Original Research and Comparison with Published Data [PDF]
Pathogens(1) Background: Meyerozyma guilliermondii is a yeast species widely distributed in the natural environment and one of the rare emerging pathogens capable of causing difficult to treat, severe infections.
Aleksandra Górzyńska +5 more
doaj +2 more sources
Candida Drug Resistance in Patients With Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis. [PDF]
Int Wound JABSTRACT Diabetic foot ulcers (DFUs) are one of the most serious and common complications that, if not treated properly, can lead to potential damage and even amputation. The aim of this systematic review and meta‐analysis was to assess the drug‐resistant Candida species in DFU.
Ekvan MH +7 more
europepmc +2 more sources
Impact of Biofilm Formation by Vaginal Candida albicans and Candida glabrata Isolates and Their Antifungal Resistance: A Comprehensive Study in Ecuadorian Women [PDF]
Journal of FungiCandida albicans and Candida glabrata are key fungal pathogens linked to candidiasis, with rising concerns due to antifungal resistance and biofilm abilities. However, data from Latin America remains limited.
Ariana Cecibel Cedeño-Pinargote +6 more
doaj +2 more sources
Study on the impact of biofilm formation by Candida albicans in recurrent vulvovaginal candidiasis on drug susceptibility [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundVulvovaginal candidiasis (VVC) and recurrent VVC (RVVC) are common fungal infections in women, often complicated by recurrence and treatment resistance.
Sainan Li +4 more
doaj +2 more sources
Successful use of isavuconazole as secondary prophylaxis of cryptococcal meningitis in a person living with HIV and AIDS: a case report [PDF]
Therapeutic Advances in Infectious DiseaseCryptococcal meningitis (CM) is a severe opportunistic infection in people living with HIV (PLWH). We report a 54-year-old man with advanced HIV infection who presented with CM due to Cryptococcus neoformans .
Carmela Pinnetti +11 more
doaj +2 more sources
Factors Influencing the Nitrogen-Source Dependent Flucytosine Resistance in Cryptococcus Species
mBio, 2023 Flucytosine (5-FC) is an antifungal agent commonly used for treatment of cryptococcosis and several other systemic mycoses. In fungi, cytosine permease and cytosine deaminase are known major players in flucytosine resistance by regulating uptake and ...
Dong-Hoon Yang +3 more
doaj +1 more source
Diagnostics, 2021 Management of cryptococcal infections among patients suffering from acquired immunodeficiency syndrome (AIDS) represents a medical challenge. This retrospective study aims to describe the disease management and outcomes among 24 AIDS patients who ...
Iosif Marincu +10 more
doaj +1 more source