Results 21 to 30 of about 9,369 (213)

A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi [PDF]

, 2013
Introduction: Cryptococcal meningitis is the most common neurological infection in HIV infected patients in Sub Saharan Africa, where gold standard treatment with intravenous amphotericin B and 5 flucytosine is often unavailable or difficult to ...
Mavuto Mukaka, Rothe, Camilla, Feasey, NA, Tom Harrison, van Oosterhout Joep J., Denis, Brigitte, Lalloo David G., Goodson, P, Rothe, C, Jean Chikafa, Sloan, DJ, Goodson, Patrick, Nicholas A Feasey, Mukaka, Mavuto, Joep J van Oosterhout, Lalloo, DG, Allain, T, Heyderman Robert S., Camilla Rothe, Harrison, T, Sloan Derek J., Harrison, Tom, Harrison Tom, Sloan, Derek J., Allain Theresa, Mukaka, M, Lalloo, David G., Theresa Allain, Goodson Patrick, Denis, B, van Oosterhout, JJ, Chikafa, Jean, Derek J Sloan, David G Lalloo, Chikafa, J, Patrick Goodson, Brigitte Denis, Rothe Camilla, Robert S Heyderman, Feasey Nicholas A., Chikafa Jean, van Oosterhout, Joep J., Mukaka Mavuto, Allain, Theresa, Feasey, Nick; id_orcid, Heyderman, RS, Feasey, Nicholas A., Denis Brigitte, Lalloo, David; id_orcid, Heyderman, Robert S.   +49 more
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Induction-phase treatment costs for cryptococcal meningitis in high HIV-burden African countries: New opportunities with lower costs [version 3; peer review: 3 approved]

Wellcome Open Research, 2022
Introduction: Access to and the cost of induction treatment for cryptococcal meningitis (CM) is rapidly changing. The newly-announced price for flucytosine ($0.75 per 500 mg pill) and possibly lower prices for liposomal amphotericin B (AmB-L) create ...
Amir Shroufi, Radha Rajasingham, Bruce Larson, Joseph N. Jarvis, Rita Oladele, Charles Muthoga, Tom M. Chiller, Alexander Jordan, Nelesh P. Govender   +8 more
doaj   +1 more source

Acquired Flucytosine Resistance during Combination Therapy with Caspofungin and Flucytosine for Candida glabrata Cystitis [PDF]

, 2016
International audienceTreatment of Candida glabrata cystitis remains a therapeutic challenge, and an antifungal combination using flucytosine is one option. We describe two patients with refractory C.
Quesne, Gilles, Legendre, Christophe, Charlier, Caroline, Lortholary, Olivier, Bachelier-Bassi, Sophie, El Sissy, Carine, Scemla, Anne, Bougnoux, Marie-Elisabeth, Sitterlé, Emilie   +8 more
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Treatment of experimental cryptococcal meningitis with fluconazole: impact of dose and addition of flucytosine on mycologic and pathophysiologic outcome [PDF]

, 1996
Fluconazole is effective in the therapy of cryptococcal meningitis in patients with AIDS. The optimal dosage of fluconazole and the impact of combination with flucytosine are not known.
Kartalija, M, Kaye, K, Täuber, MG, Tureen, JH, Liu, Q, Elliott, BR, Sande, MA   +6 more
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AMBITION-cm : intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa : study protocol for a randomized controlled trial [PDF]

, 2015
Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine, and difficulties administering 14 days of amphotericin B are key ...
Leeme, Tshepo, Síle F. Molloy, Changalucha, John M., Molefi, Mooketsi, Molloy, Síle F, Meintjes, Graeme, Molloy, Síle F., Goldberg, Drew W, John R. Perfect, Drew W. Goldberg, Kalluvya, Samuel, Cainelli, Francesca, Letang, Emili, Ndhlovu, Chiratidzo E, Perfect, John R, Ndhlovu, Chiratidzo E., Bisson, Gregory P., Miriam Haverkamp, Burton, Rosie, Rosie Burton, Tariro Makadzange, Harrison, Thomas S, Francesca Cainelli, Hope, William, Haverkamp, Miriam, Chiratidzo E. Ndhlovu, Harrison, Thomas S., Jarvis, Joseph N., Chofle, Awilly A, William Hope, Jarvis, Joseph N, Changalucha, John M, Fenner, Lukas, Perfect, John R., Makadzange, Tariro, Joseph N. Jarvis, Tshepo Leeme, Mooketsi Molefi, Nametso Lekwape, Lekwape, Nametso, John M. Changalucha, Emili Letang, Goldberg, Drew W., Lukas Fenner, Bisson, Gregory P, Awilly A. Chofle, Samuel Kalluvya, Thomas S. Harrison, Graeme Meintjes, Chofle, Awilly A., Gregory P. Bisson   +50 more
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Flucytosine therapeutic monitoring: 15 years experience from the UK [PDF]

, 2007
Background: There is uniform consensus that flucytosine blood concentrations should be measured to avoid toxicity and ensure adequate efficacy. Objectives and methods: The purpose of this study was to evaluate all flucytosine levels performed in a ...
C. B. Moore, Howard, S. J., D. W. Denning, Denning, D. W.; id_orcid, A. C. Pasqualotto, Pasqualotto, A. C., Moore, C. B., S. J. Howard   +7 more
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Antifungal Drugs

Metabolites, 2020
We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein ...
Jiří Houšť, Jaroslav Spížek, Vladimír Havlíček   +2 more
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Creation of Bioorthogonal Redox Systems Depending on Nicotinamide Flucytosine Dinucleotide [PDF]

, 2011
Creation of Bioorthogonal Redox Systems Depending on Nicotinamide Flucytosine DinucleotideMany enzymes catalyzing biological redox chemistry depend on the omnipresent cofactor, nicotinamide adenine dinucleotide (NAD).
Wang, Jinxia, 赵宗保, Hou, Shuhua, Wang, Lei, Wang, Qian, Zhao, Zongbao K., Ji, Debin, Liu, Wujun   +7 more
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New Horizons in Antifungal Therapy

Journal of Fungi, 2016
Recent investigations have yielded both profound insights into the mechanisms required by pathogenic fungi for virulence within the human host, as well as novel potential targets for antifungal therapeutics.
Kaila M. Pianalto, J. Andrew Alspaugh
doaj   +1 more source

Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days. [PDF]

, 2014
Cryptococcal meningoencephalitis is an urgent global health problem. Induction regimens using 14 days of amphotericin B deoxycholate (dAmB) are considered the standard of care but may not be suitable for resource-poor settings.
Sharp, Andrew D, Andrew D. Sharp, Julie A. Schwartz, Gregson, Lea, Howard, Susan J, Goodwin, Joanne, Susan J. Howard, Bill Moser, John R. Perfect, Müller, W, Sharp, AD, Joanne Goodwin, Moser, Bill, Walker, Catherine, Hope, William W, Lea Gregson, Hope, WW, Perfect, John R, Joanne Livermore, Werner Müller, Schwartz, JA, William W. Hope, Felton, Timothy; id_orcid, Timothy Felton, Catherine Walker, Livermore, J, Schwartz, Julie A, Gregson, L, Goodwin, J, Harrison, Thomas S, Livermore, Joanne, Howard, SJ, Felton, T, Harrison, TS, Walker, C, Perfect, JR, Thomas S. Harrison, Müller, Werner; id_orcid, Moser, B   +38 more
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