Results 11 to 20 of about 9,329 (213)

Study on the impact of biofilm formation by Candida albicans in recurrent vulvovaginal candidiasis on drug susceptibility [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundVulvovaginal candidiasis (VVC) and recurrent VVC (RVVC) are common fungal infections in women, often complicated by recurrence and treatment resistance.
Sainan Li, Zijia Shen, Suke Wang, Yongmei Peng, Wenjin Qi   +4 more
doaj   +2 more sources

Factors Influencing the Nitrogen-Source Dependent Flucytosine Resistance in Cryptococcus Species

mBio, 2023
Flucytosine (5-FC) is an antifungal agent commonly used for treatment of cryptococcosis and several other systemic mycoses. In fungi, cytosine permease and cytosine deaminase are known major players in flucytosine resistance by regulating uptake and ...
Dong-Hoon Yang, Ami Khanal Lamichhane, Kyung J. Kwon-Chung, Yun C. Chang   +3 more
doaj   +1 more source

Clinical Profile of 24 AIDS Patients with Cryptococcal Meningitis in the HAART Era: A Report from an Infectious Diseases Tertiary Hospital in Western Romania

Diagnostics, 2021
Management of cryptococcal infections among patients suffering from acquired immunodeficiency syndrome (AIDS) represents a medical challenge. This retrospective study aims to describe the disease management and outcomes among 24 AIDS patients who ...
Iosif Marincu, Cosmin Citu, Iulia Vidican, Felix Bratosin, Mihai Mares, Oana Suciu, Stefan Frent, Adrian Vasile Bota, Madalina Timircan, Melania Lavinia Bratu, Mirela Loredana Grigoras   +10 more
doaj   +1 more source

Epidemiological and Clinical Characteristics, Antifungal Susceptibility, and MLST-Based Genetic Analysis of Cryptococcus Isolates in Southern Taiwan in 2013–2020

Journal of Fungi, 2022
Cryptococcal meningoencephalitis (CM) is a treatable condition, but it leads to excessive morbidity and mortality. We collected 115 non-duplicated Cryptococcus clinical isolates during 2013–2020 in southern Taiwan to perform antifungal susceptibility ...
Yi-Chun Chen, Shu-Fang Kuo, Shang-Yi Lin, Yin-Shiou Lin, Chen-Hsiang Lee   +4 more
doaj   +1 more source

Induction-phase treatment costs for cryptococcal meningitis in high HIV-burden African countries: New opportunities with lower costs [version 2; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2022
Introduction: Access to and the cost of induction treatment for cryptococcal meningitis (CM) is rapidly changing. The newly-announced price for flucytosine ($0.75 per 500 mg pill) and possibly lower prices for liposomal amphotericin B (AmB-L) create ...
Amir Shroufi, Radha Rajasingham, Bruce Larson, Joseph N. Jarvis, Rita Oladele, Charles Muthoga, Tom M. Chiller, Alexander Jordan, Nelesh P. Govender   +8 more
doaj   +1 more source

Adaptation to Fluconazole via Aneuploidy Enables Cross-Adaptation to Amphotericin B and Flucytosine in Cryptococcus neoformans

Microbiology Spectrum, 2021
The high morbidity and mortality of cryptococcal meningitis is due to the limited range of therapeutic options: only three classes of antifungal drugs are available (polyenes [amphotericin B], azoles [fluconazole], and pyrimidine analogues [flucytosine]).
Feng Yang, Vladimir Gritsenko, Hui Lu, Cheng Zhen, Lu Gao, Judith Berman, Yuan-ying Jiang   +6 more
doaj   +1 more source

Candida Drug Resistance in Patients With Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis. [PDF]

Int Wound J
ABSTRACT Diabetic foot ulcers (DFUs) are one of the most serious and common complications that, if not treated properly, can lead to potential damage and even amputation. The aim of this systematic review and meta‐analysis was to assess the drug‐resistant Candida species in DFU.
Ekvan MH, Sayyadi H, Alidadpour S, Karimi M, Getso MI, Ebrahimi AR, Mirpanahi M, Raiesi O.   +7 more
europepmc   +2 more sources

Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis. [PDF]

, 2023
BACKGROUND: There are limited data describing clinical flucytosine pharmacokinetics (PK). The variability of flucytosine partitioning into the CNS is not known.
Gondwe, Ebbie, Lawrence, David S., Moyo, M, Hope, W, Shah, RV, Jagota, Bhavana, Kajanga, Cheusisime, Kajanga, C, Ahmadu, Ajisa, Lawrence, David S, Mwandumba, HC, Jagota, B, Shah, Reya V., Lalloo, DG, Mwandumba, Henry, Harrison, T, Jarvis, JN, Lalloo, David G, Jimenez-Valverde, Ana, Jimenez-Valverde, A, Unsworth, Jennifer, Lawrence, DS, Stott, KE, Stott, Katharine E., Chasweka, M, Harrison, Tom, Gondwe, E, Moyo, Melanie, Mwandumba, Henry C, Stott, Katharine E, Shah, Reya V, Hope, William, Unsworth, J, Chimang'anga, Wezzie, Chimang'anga, W, Lalloo, David; id_orcid, Jarvis, Joseph N., Chasweka, Madalitso, Jarvis, Joseph N, Ahmadu, A   +39 more
core   +1 more source

Prevalence of cryptococcal meningitis among people living with human immuno-deficiency virus and predictors of mortality in adults on induction therapy in Africa: A systematic review and meta-analysis

Frontiers in Medicine, 2022
BackgroundCryptococcal meningitis (CM) is a leading cause of adult meningitis in countries with a high burden of HIV. It has remained a significant cause of morbidity and mortality in Africa despite the extensive rollout of HIV antiretroviral therapy ...
Seke G. Y. Muzazu, Seke G. Y. Muzazu, Dawit Getachew Assefa, Dawit Getachew Assefa, Christabel Phiri, Tewodros Getinet, Samrawit Solomon, Gizachew Yismaw, Tsegahun Manyazewal   +8 more
doaj   +1 more source

A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi [PDF]

, 2013
Introduction: Cryptococcal meningitis is the most common neurological infection in HIV infected patients in Sub Saharan Africa, where gold standard treatment with intravenous amphotericin B and 5 flucytosine is often unavailable or difficult to ...
Mavuto Mukaka, Rothe, Camilla, Feasey, NA, Tom Harrison, van Oosterhout Joep J., Denis, Brigitte, Lalloo David G., Goodson, P, Rothe, C, Jean Chikafa, Sloan, DJ, Goodson, Patrick, Nicholas A Feasey, Mukaka, Mavuto, Joep J van Oosterhout, Lalloo, DG, Allain, T, Heyderman Robert S., Camilla Rothe, Harrison, T, Sloan Derek J., Harrison, Tom, Harrison Tom, Sloan, Derek J., Allain Theresa, Mukaka, M, Lalloo, David G., Theresa Allain, Goodson Patrick, Denis, B, van Oosterhout, JJ, Chikafa, Jean, Derek J Sloan, David G Lalloo, Chikafa, J, Patrick Goodson, Brigitte Denis, Rothe Camilla, Robert S Heyderman, Feasey Nicholas A., Chikafa Jean, van Oosterhout, Joep J., Mukaka Mavuto, Allain, Theresa, Feasey, Nick; id_orcid, Heyderman, RS, Feasey, Nicholas A., Denis Brigitte, Lalloo, David; id_orcid, Heyderman, Robert S.   +49 more
core   +1 more source