Results 41 to 50 of about 9,369 (213)

Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity [PDF]

, 2013
""Although antibiotic resistance represents a public health emergency, the pipeline of new antibiotics is running dry. Repurposing of old drugs for new clinical applications is an attractive strategy for drug development.
Facchini, Marcella, E. Frangipani, L. Leoni, LEONI, Livia, VISAGGIO, DANIELA, Bragonzi A, Visaggio D, D. Visaggio, Imperi, Francesco, F. Massai, VISCA, PAOLO, Massai F, Imperi F, Facchini M, Bragonzi, Alessandra, FRANGIPANI, EMANUELA, MASSAI, FRANCESCO, P. Visca, M. Facchini, A. Bragonzi   +19 more
core   +1 more source

Clinical Value of Metagenomic Next‐Generation Sequencing Versus Conventional Methods in Diagnosing Cryptococcal Infection After Kidney Transplantation

Organ Medicine, EarlyView.
This retrospective study evaluated metagenomic next‑generation sequencing (mNGS) against conventional methods (India ink, culture, antigen) for diagnosing cryptococcal infection in 16 kidney transplant recipients. mNGS showed a significantly higher positivity rate (93.8% vs 62.5%, p = 0.031) and shorter turnaround time (24 vs. 120 h, p < 0.001).
Luhao Liu, Rongxin Chen, Haonan Lin, Yuhe Guo, Guanghui Li, Jiali Fang, Zheng Chen   +6 more
wiley   +1 more source

Antifungal susceptibility of non-albicans Candida spp. isolated from raw milk and human blood in Alborz and Tehran provinces

Iranian Journal of Microbiology, 2020
Background and Objectives: Recent reports indicate high prevalence of fungal infections due to non-albicans Candida spp. which are present in various environments such as raw milk.
Zahra Namvar, Abbas Akhavan Sepahy, Robab Rafiei Tabatabaei, Sassan Rezaie   +3 more
doaj   +1 more source

Flucytosine-fluconazole cross-resistance in purine-cytosine permease-deficient Candida lusitaniae clinical isolates: indirect evidence of a fluconazole uptake transporter [PDF]

, 2003
An unusual interaction between flucytosine and fluconazole was observed when a collection of 60 Candida lusitaniae clinical isolates was screened for cross-resistance.
Noël, Thierry, Paumard, Patrick, Villard, Jean, Chastin, Christiane, François, Fabienne, Brèthes, Daniel   +5 more
core   +1 more source

A Pilot Study Showing Fluconazole and Flucytosine Activities against Candida glabrata are Affected by Low pH: Implications for the Treatment of Recurrent Vulvovaginal Candidiasis

Clinical and Experimental Obstetrics & Gynecology
Background: Candida albicans (C. albicans) and Candida glabrata (C. glabrata) are mainly associated with vulvovaginal candidiasis (VVC). Management of VVC caused by C.
Ziauddin Khan, Suhail Ahmad, Mohammad Asadzadeh   +2 more
doaj   +1 more source

Symptomatic Cryptococcal Meningitis with Negative Serum and Cerebrospinal Fluid Cryptococcal Antigen Tests

HIV/AIDS: Research and Palliative Care, 2021
Vivien Nanfuka,1,* Mkhoi L Mkhoi,2– 4,* Jane Gakuru,2 Richard Kwizera,2 Joseph Baruch Baluku,5 Felix Bongomin,6,7 David B Meya1,2,6 1Infectious Diseases Unit, Kiruddu National Referral Hospital, Kampala, Uganda; 2Infectious Diseases Institute ...
Nanfuka V, Mkhoi ML, Gakuru J, Kwizera R, Baluku JB, Bongomin F, Meya DB   +6 more
doaj  

Parallel and cross-resistances of clinical yeast isolates determined by susceptibility pattern analysis

GMS Infectious Diseases, 2016
For calculated initial antifungal therapy, knowledge on parallel and cross-resistances are vitally important particularly in the case of multiresistant isolates.
Schmalreck, Arno F., Willinger, Birgit, Idelevich, Evgeny A., Fegeler, Christian, Lass-Flörl, Cornelia, Fegeler, Wolfgang, Becker, Karsten   +6 more
doaj   +1 more source

Epidemiology and Outcomes of Cryptococcal Infections in Liver Transplant Recipients: A Retrospective Cohort Study at a US Academic Center

Transplant Infectious Disease, EarlyView.
Among 346 liver transplant recipients, rural residence conferred a 3.3‐fold higher risk of cryptococcal infection — a novel finding suggesting environmental exposure or healthcare access barriers may drive susceptibility. Triple immunosuppression and longer waitlist duration were additional risk factors, with very early infection carrying the worst ...
Rachel Sigler, Chloe Hanigan, Atikur Rahman, Isuru Ratnayake, Phani Akella, Lauren Carlini, Chelsea Gorsline, Erica Mackenzie, Albert Eid, Dennis Shoemaker, Ryan Taylor, Stephen Waller   +11 more
wiley   +1 more source

Liposomal flucytosine capped with gold nanoparticle formulations for improved ocular delivery [PDF]

, 2016
Heba F Salem,1 Sayed M Ahmed,2 Mahmoud M Omar3 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt; 2Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt ...
Salem HF, Ahmed SM, Omar MM
core  

Formulation and evaluation of flucytosine-loaded nanoemulgel for enhanced antifungal activity through in vitro and in vivo studies

Journal of Applied Pharmaceutical Research
Background: Fungal skin infections constitute a prevalent global health issue, accompanied by increasing resistance to traditional antifungal medications.
Rajat Srivastava, Ajay Kumar Singh Rawat   +1 more
doaj   +1 more source