Results 61 to 70 of about 9,329 (213)

Repositioning 2‐Mercaptobenzothiazole and Sulfonamides as Antifungals Against Multidrug‐Resistant Candida albicans: In Vitro and In Silico Insights

ChemistrySelect, Volume 11, Issue 19, 20 May 2026.
This study highlights the antifungal potential of 2‐mercaptobenzothiazole (MBT) and sulfonamides against multidrug‐resistant Candida albicans. In vitro assays and molecular docking with lanosterol 14α‐demethylase (L14αDM) reveal favorable activity and binding, supporting their repositioning as promising antifungal candidates. ABSTRACT Fungal infections
Bruno A. de Oliveira, Ari Sérgio de Oliveira Lemos, Gabrielle Silva de Campos Lazzarini, Natasha Silva Mayrink, Elaine Soares Coimbra, Adilson D. da Silva, Rodrigo Luiz Fabri   +6 more
wiley   +1 more source

Emergence of Flucytosine-Resistant Candida tropicalis Clade, the Netherlands

Emerging Infectious Diseases
Candida tropicalis is the second most virulent Candida species after C. albicans. Previous studies from the Netherlands and France reported a notable reduction in susceptibility to flucytosine (5-FC) in a substantial proportion of C. tropicalis isolates.
Fatima Zohra Delma, Bram Spruijtenburg, Jacques F. Meis, Auke W. de Jong, James Groot, Johanna Rhodes, Willem J.G. Melchers, Paul E. Verweij, Theun de Groot, Eelco F.J. Meijer, Jochem B. Buil   +10 more
doaj   +1 more source

Surgical treatment of an intracranial Cryptococcus granuloma in a cat

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Summary A 4‐year‐old, female, neutered, domestic short‐haired cat presented with an acute onset of progressive compulsive pacing and obtundation. General physical examination revealed a crusty nasal discharge, with neurological examination showing a forebrain localisation.
Guido Bertoldi, Elsa Beltran, Marta Gruarin, Deepa Cavalli‐Sforza Guitart, Joe Fenn   +4 more
wiley   +1 more source

Flucytosine for treatment of Candida albicans in H1N1-positive patient

, 2010
A 17-year-old H1N1-positive patient was successfully extubated after 25 days of ventilatory support for treatment of viral pneumonia which was complicated by empyema thoracis due to Candida albicans.
Desh Deepak, Yadav, Amlendu, Pawar, Mridula, Tanvir Samra, Mridula Pawar, Amlendu Yadav, Samra, Tanvir, Banerjee, Neerja, Deepak, Desh, Neerja Banerjee   +9 more
core   +1 more source

Invasive Fungal Infections After Intestine Transplantation: Epidemiology and Outcomes

Mycoses, Volume 69, Issue 5, May 2026.
ABSTRACT Background Invasive fungal infections (IFIs) represent a major complication after intestine transplantation, with reported incidence rates between 40% and 49%. These infections are associated with high morbidity and allograft loss. This study evaluates the impact of post‐transplant IFIs on graft outcomes in intestine transplant recipients ...
Mayyadah H. Alabdely, Jessica Lum, Blanca E. Gonzalez, Masato Fujiki, Zachary A. Yetmar   +4 more
wiley   +1 more source

Stability and bioavailability of a flucytosine suspension

, 1994
The stability and bioavailability of a suspension of flucytosine was evaluated. There was found to be no change in the flucytosine content of the suspension over a three month period.
R H Pryce-Jones, J R Johnson, D C McPhail   +2 more
core   +1 more source

Immunocompromised Status Definition in Observational Studies Using Electronic Health Records: A Scoping Review and a Proposal for a Phenotype Identification Algorithm

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau, Nicoletta Luxi, Fabio Riefolo, Martín Solorzano, Irene Pazos, Elena Ballarín, Lise Skovgaard Svingel, Lorenzo Chiusaroli, Elisa Martín‐Merino, Elisa Barbieri, María Lopez‐Lasanta, Sima Mohammadi, Denis Rotta, Alexandra Pacurariu, Catherine Cohet, Miriam Sturkenboom, Carlos E. Durán, on behalf of the SAFETY‐VAC study consortium, Carlos E. Durán, Miriam Sturkenboom, Judit Riera‐Arnau, Nicoletta Luxi, Olaf Klungel, Patrick Souverein, Sima Mohammadi, Fabio Riefolo, Irene Pazos, Rosa Gini, Davide Messina, Giuseppe Roberto, Carlo Giaquinto, Elisa Barbieri, Luca Stona, Felipe Villalobos, Martín Solorzano, Carlo Alberto Bissacco, Antonio Gimeno, Beatriz Poblador, Mercedes Aza, Aida Moreno, Alejandro Santos, Vera Ehrenstein, Lise Skovgaard Svingel, Benjamin Randeris Johannesen, Cécile Droz‐Perroteau, Laure Carcaillon‐Bentata, Anna‐Mija Tolppanen, Sirpa Hartikainen, Thuan Vo, Anne Paakinaho, Blair Rajamaki, Hedvig Nordeng, Saeed Hayati, Mahmoud Zidan, Juan José Carreras Martínez, Arantxa Urchueguía Fornes, Elisa Correcher Martínez, Javier Díez‐Domingo, Mar Martin, Patricia Garcia‐Poza, Airam de Burgos, Belén Castillo‐Cano, Elisa Martín‐Merino   +62 more
wiley   +1 more source

Flucytosine and cryptococcosis : which in vitro test is the best predictor of outcome?

, 2003
The combination of flucytosine and amphotericin B is first choice treatment for active cryptococcosis. Because of innate or acquired resistance of Cryptococcus neoformans to flucytosine, in vitro testing is mandatory.
A.M. Tortorano, M.C. Esposto, M.A. Savoldelli, M. Cogliati   +3 more
core   +1 more source

The Epidemiology and Infection Control of Candida Auris in Shanghai

Mycoses, Volume 69, Issue 4, April 2026.
ABSTRACT Background Candida auris is a globally emerging multidrug‐resistant fungus. Its dissemination is driven by patient movement and asymptomatic carriers. However, molecular epidemiological studies linking imported cases to local strains in large metropolitan areas remain limited.
Mingjing Wei, Jian Guo, Li Li, Junhao Zhu, Yuyuan Xue, Guo Chen, Fan Yang, Wenjuan Wu, Min Zhu   +8 more
wiley   +1 more source

Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity

, 2013
""Although antibiotic resistance represents a public health emergency, the pipeline of new antibiotics is running dry. Repurposing of old drugs for new clinical applications is an attractive strategy for drug development.
Facchini, Marcella, E. Frangipani, L. Leoni, LEONI, Livia, VISAGGIO, DANIELA, Bragonzi A, Visaggio D, D. Visaggio, Imperi, Francesco, F. Massai, VISCA, PAOLO, Massai F, Imperi F, Facchini M, Bragonzi, Alessandra, FRANGIPANI, EMANUELA, MASSAI, FRANCESCO, P. Visca, M. Facchini, A. Bragonzi   +19 more
core   +1 more source