Results 51 to 60 of about 9,369 (213)

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source

Walsh & Hoyt: Flucytosine [PDF]

, 2005
Flucytosine (5-fluorocytosine) is the fluorine analogue of the naturally occurring nucleic acid pyrimidine base, cytosine. Flucytosine inhibits deoxyribonucleic acid (DNA) synthesis within fungi by acting as a noncompetitive inhibitor of thymidylate ...
Joel M. Weinstein, MD
core  

Flucytosine-induced colitis [PDF]

BMJ Case Reports, 2014
A 52-year-old man with a history of HIV (CD4 count 155, and viral load 154 K), who is on antiretroviral treatment presented in the emergency room with acute onset of headache. The patient had lumbar puncture and found to have elevated intracranial pressure and cryptococcal antigen was positive. The patient was started on flucytosine.
Muhammad Adnan, Sohail, Muhammad, Adnan Sohail, Umaira, Ikram   +2 more
openaire   +2 more sources

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Detection of FUR1 Gene in 5-Flucytosine Resistant Candida Isolates in Vaginal Candidiasis Patients [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background and Aims: This study was done to detect the prevalence, risk factors for vaginal candidiasis in Chennai and to evaluate different methods for speciation of Candida isolates from vaginal candidiasis patients.
Sasikala Gopinathan, Anand B. Janagon D, David Agatha, Thenmozhivalli P.R.   +3 more
doaj   +1 more source

Flucytosine Monotherapy for Cryptococcosis [PDF]

Clinical Infectious Diseases, 1998
Flucytosine (5-FC) monotherapy for cryptococcosis is not advocated because drug resistance emerges during therapy. Reported documentation of this widely accepted belief is surprisingly scarce. Therefore, we reviewed our experience with 5-FC monotherapy for 27 patients treated between 1968 and 1973.
D R, Hospenthal, J E, Bennett
openaire   +2 more sources

Prediction and experimental validation of solid solutions and isopolymorphs of cytosine/5-flucytosine [PDF]

, 2017
A computational search for polymorphs of cytosine, 5-flucytosine and a 1 : 1 mixture of the two substances not only rationalised the preferred packing arrangements but also enabled the finding and characterisation of cytosine/5-flucytosine solid ...
Braun, D. E., Griesser, U. J., U. J. Griesser, D. E. Braun   +3 more
core   +1 more source

Granulocytopenia and Thrombocytopenia Associated with Combination Therapy of Amphotericin B and Low-Dose Flucytosine in a Patient with Cryptococcal Meningitis [PDF]

, 1989
A patient was admitted complaining of fever and headache. He was suspected of meningitis due to nuchal rigidity, and a lumbar puncture was performed. The patient was diagnosed as having cryptococcal meningitis, as Cryptococcus neoformans was found in an
Kunihiko Shindo, Masanori Matsumura, Tadaoki Mizuno, Yoshimi Hashimoto, Akira Ito, Yutaka Matsumoto, Hiroshi Shionoiri   +6 more
core   +1 more source

Oral Cryptococcosis due to Naganishia diffluens in a Patient With Thalassemia: A Case Report and a Literature Review

Journal of Clinical Laboratory Analysis, Volume 40, Issue 11, June 2026.
Naganishia diffluens, a rare non‐neoformans cryptococcal species, was identified by PCR sequencing as the causative agent of oral cryptococcosis in a 31‐year‐old Iranian man with β‐thalassemia. This case represents the first documented instance of oral infection by N.
Zahra Yahyazadeh, Zeynab Haseli, Javad Javidnia, Mahdi Abastabar, Eisa Nazar, Hosein Jalali, Mohamad Taghi Hedayati, Hossein Karami, Mohsen Nosratabadi, Lotfollah Davoodi, Seyyed Reza Aghili, Maryam Moazeni, Iman Haghani, Hamid Badali   +13 more
wiley   +1 more source

Rapid in vitro evolution of flucytosine resistance in Candida auris

mSphere
The pan-antifungal-resistant pathogen Candida auris has been causing high-mortality infection outbreaks in hospitals and healthcare settings. The prodrug 5-fluorocytosine (5FC) is one of four chemical entities, but its clinical use as an antifungal drug ...
Trinh Phan-Canh, Duc-Minh Nguyen-Le, Phuc-Loi Luu, Narakorn Khunweeraphong, Karl Kuchler   +4 more
doaj   +1 more source