Results 51 to 60 of about 2,218 (130)

Antifungal susceptibilities of Cryptococcus species complex isolates from AIDS and non-AIDS patients in Southeast China

Brazilian Journal of Infectious Diseases, 2012
Cryptococcus spp. are common causes of mycoses in immunocompromised patients. To determine the drug susceptibilities of clinical Cryptococcus spp. isolates, the characteristics of 61 clinical Cryptococcus spp.
Meng Li, Yong Liao, Min Chen, Weihua Pan, Lixing Weng   +4 more
doaj   +1 more source

Long‐Term Use of Rezafungin: A Case Report and Insights Into Real‐World Access

Transplant Infectious Disease, EarlyView.
Jian Mei Li, Jacqueline E. Clark, Tiffany Wu   +2 more
wiley   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

A Flucytosine-Responsive Mbp1/Swi4-Like Protein, Mbs1, Plays Pleiotropic Roles in Antifungal Drug Resistance, Stress Response, and Virulence of Cryptococcus neoformans [PDF]

, 2012
Cryptococcosis, caused by the basidiomycetous fungus Cryptococcus neoformans , is responsible for more than 600,000 deaths annually in AIDS patients. Flucytosine is one of the most commonly used antifungal drugs for its treatment,
Joseph Heitman, Nielsen, Kirsten, Bahn, Yong-Sun, Anna Floyd, Song, Min-Hee, Yong-Sun Bahn, Yoon, Ja-Kyung, Theodore C. White, Min Su Kim, Ja-Kyung Yoon, Floyd, Anna, Kim, Min Su, Strain, Anna K., Judith N. Nielsen, Nielsen, Judith N., White, Theodore C., Lee, Jang-Won, Jang-Won Lee, Min-Hee Song, Heitman, Joseph, Kirsten Nielsen, Anna K. Strain   +21 more
core   +1 more source

Response Surface Methodology-Guided Optimization of Flucytosine Nanoemulsion for Enhanced Antifungal Performance

European Pharmaceutical Journal
Although flucytosine is a powerful antifungal drug, formulation-related issues frequently restrict its clinical usage, and the growing prevalence of invasive fungal infections caused by Candida and Cryptococcus species poses a serious public health ...
Tiwari Priya, Verma Shipra, Saini Gajendra   +2 more
doaj   +1 more source

Emergence of Flucytosine-Resistant Candida tropicalis Clade, the Netherlands

Emerging Infectious Diseases
Candida tropicalis is the second most virulent Candida species after C. albicans. Previous studies from the Netherlands and France reported a notable reduction in susceptibility to flucytosine (5-FC) in a substantial proportion of C. tropicalis isolates.
Fatima Zohra Delma, Bram Spruijtenburg, Jacques F. Meis, Auke W. de Jong, James Groot, Johanna Rhodes, Willem J.G. Melchers, Paul E. Verweij, Theun de Groot, Eelco F.J. Meijer, Jochem B. Buil   +10 more
doaj   +1 more source

Pulmonary Cryptococcosis in Apparently Immunocompetent Hosts: Host Susceptibility, Occult Immunodeficiency and Clinical Implications

Mycoses, Volume 69, Issue 8, August 2026.
ABSTRACT Pulmonary cryptococcosis (PC) in apparently immunocompetent hosts—now the majority of non‐HIV cases in Asia—cannot be explained by the traditional opportunistic infection paradigm. Three epidemiological observations point toward occult immune susceptibility: familial clustering documented in multiple case reports and small family studies ...
Ran Ma, Xinyan Yang
wiley   +1 more source

Effect of flucytosine on paramagnetic properties of Cladosporium cladosporioides [PDF]

, 2009
Zbadano właściwości paramagnetyczne upigmentowanych grzybów glebowych Cladosporium cladosporioides oraz ich kompleksów z flucytozyną z zastosowaniem spektroskopii EPR.
Zdybel, M., Cieśla, H., Pilawa, B., Witoszyńska, T., Buszman, E.   +4 more
core  

Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method

Canadian Journal of Infectious Diseases, 1992
The in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium ...
Abdul H Chagla, John H Hii, Daryl J Hoban, Andrew E Simor, Santiago Ferro, Evelyn Witwicki, Ruby Poon, Donald E Low   +7 more
doaj   +1 more source

Central Nervous System Infections in Pediatric Solid Organ Transplant Recipients

Pediatric Transplantation, Volume 30, Issue 8, August 2026.
CNS infections in SOT recipients are rare and presentation can be subtle. Therefore, a low threshold for evaluation is warranted to minimize the associated mortality. ABSTRACT Background Solid organ transplant (SOT) recipients face an increased risk of central nervous system (CNS) infections due to immunosuppression.
Amna AlSaihati, Kathleen E. Hosek, Cristina Otero, Brandon H. Tran, Carrie A. Mohila, David Moreno McNeill, Mini Michael, Krupa R. Mysore, Joseph A. Spinner, Claire E. Bocchini, Kristen G. Valencia Deray   +10 more
wiley   +1 more source