Results 41 to 50 of about 1,272,091 (279)
Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi [PDF]
, 2008 Background: In contrast to the increasing numbers of agents for the treatment of invasive fungal infections, discoveries of new antifungal agents with therapeutic value in dermatomycoses are reported only rarely.
Borelli, Claudia +10 more
core +1 more source
Suspected adverse reactions to antifungal drugs requiring change to or withholding of treatment.
, 2023 Suspected adverse reactions to antifungal drugs requiring change to or withholding of treatment.
Anna P. Ralph (8637447) +11 more
core +1 more source
Journal of Fungi, 2023 With only four classes of antifungal drugs available for the treatment of invasive systemic fungal infections, the number of resistant fungi is increasing, highlighting the urgent need for novel antifungal drugs.
Keiko Nakano +5 more
doaj +1 more source
Introduction to Antifungal Drugs [PDF]
Clinical Infectious Diseases, 2000 In the United States, only 10 antifungal drugs are currently approved by the Food and Drug Administration (FDA) for the therapy of systemic fungal infections. As shown in table 1, these drugs belong to 3 principal classes: polyenes, pyrimidines, and azoles.
openaire +2 more sources
Novel Antifungal Compounds Discovered in Medicines for Malaria Venture’s Malaria Box
mSphere, 2018 Similarities in fungal and animal cells make antifungal discovery efforts more difficult than those for other classes of antimicrobial drugs. Currently, there are only three major classes of antifungal drugs used for the treatment of systemic fungal ...
Eric H. Jung +3 more
doaj +1 more source
Missed Opportunities for Antifungal Stewardship during the COVID-19 Era
Antibiotics, 2023 Significant increases in antibacterial use were observed during the COVID-19 pandemic. However, subsequent analyses found this increase in antibiotic use to be excessive in comparison with the relatively low rates of bacterial coinfection.
Brandon K. Hawkins +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Outcome of patients treated with antifungal drugs.
, 2019 Outcome of patients treated with antifungal drugs.
Anna Grancini (5022224) +11 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2022 Candida auris is an emerging fungal pathogen that commonly causes nosocomial blood infections in the immunocompromised. Several factors make this pathogen a global threat, including its misidentification as closely related species, its ability to survive
Cornelison, Christopher T. +9 more
core +1 more source