Results 11 to 20 of about 92,209 (296)
Metabolites, 2020 We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein ...
Jiří Houšť +2 more
doaj +6 more sources
Sources of Antifungal Drugs [PDF]
Journal of Fungi, 2023 Due to their eukaryotic heritage, the differences between a fungal pathogen’s molecular makeup and its human host are small. Therefore, the discovery and subsequent development of novel antifungal drugs are extremely challenging.
Giel Vanreppelen +3 more
doaj +5 more sources
Repurposing antifungal drugs for cancer therapy [PDF]
Journal of Advanced Research, 2023 Background: Repurposing antifungal drugs in cancer therapy has attracted unprecedented attention in both preclinical and clinical research due to specific advantages, such as safety, high-cost effectiveness and time savings compared with cancer drug ...
Ningna Weng +5 more
doaj +4 more sources
Frontiers in Pharmacology, 2022 Aims: We aimed to estimate the risk of drug-induced liver injury (DILI) from various antifungal treatments with azoles and echinocandins causing in real-world practice.Methods: We performed disproportionality and Bayesian analyses based on data from the ...
Zhi-Xuan Zhou +13 more
doaj +3 more sources
Synergistic antifungal effects and mechanisms of amantadine hydrochloride combined with azole antifungal drugs on drug-resistant Candida albicans [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionThe increasing resistance of Candida albicans (C. albicans) to conventional antifungal drugs poses a great challenge to the clinical treatment of infections caused by this yeast.
Xiuyun Li +5 more
doaj +2 more sources
Heliyon, 2020 The human pathogenic yeast genus Malassezia may be an etiological agent of skin disorders and has received considerable attention from dermatologists in recent years.
Kaiqin Wang +12 more
doaj +3 more sources
Chemometric Methods—A Valuable Tool for Investigating the Interactions Between Antifungal Drugs (Including Antifungal Antibiotics) and Food [PDF]
AntibioticsBackground/Objectives: Developing antifungal drugs with lower potential for interactions with food may help to optimize treatment and reduce the risk of antimicrobial resistance.
Agnieszka Wiesner-Kiełczewska +3 more
doaj +2 more sources
Antifungal Nanomaterials: Current Progress and Future Directions [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2021 Fungal infection poses a severe threat to human health worldwide resulting in a serious problem in clinic. Due to the limited arsenal of existing antifungal drugs, the nanomaterials were thus regarded as the candidate for developing new antifungal drugs.
Jia-Le Xu +4 more
doaj +1 more source
Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model-Informed Dosing Recommendations for Anticancer Drugs. [PDF]
CPT Pharmacometrics Syst PharmacolGoosen TC +6 more
europepmc +3 more sources
Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis. [PDF]
Front Microbiol, 2023 Sun LL +5 more
europepmc +3 more sources