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Molecular basis of resistance to azole antifungals
Trends in Molecular Medicine, 2002The increased incidence of invasive mycoses and the emerging problem of antifungal drug resistance has prompted investigations of the underlying molecular mechanisms, particularly for the azole compounds central to current therapy. The target site for the azoles is the ERG11 gene product, the cytochrome P450 lanosterol 14alpha-demethylase, which is ...
LUPETTI, ANTONELLA +4 more
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CLINICAL RELEVANCE OF ANTIFUNGAL RESISTANCE
Infectious Disease Clinics of North America, 1997The availability of standard guidelines (NCCLS M27 document) for antifungal susceptibility testing has facilitated the establishment of tentative interpretive breakpoints for fluconazole and itraconazole by the NCCLS. Based on correlations of MIC values with the outcomes of patients with mostly Candida infections, fluconazole MICs of > or = 64 and ...
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Antifungal Resistance: An Emerging Battlefield
Future Microbiology, 2020Patrick C. Y. Woo +2 more
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Editorial: Resistance to antifungal agents
Fungal Genetics and Biology, 2010openaire +3 more sources