Results 111 to 120 of about 42,196 (291)
Cutaneous Alternariosis in Immunosuppressed Patients Treated with Photodynamic Therapy and Oral Antifungals, a Synergistic Strategy [PDF]
Cutaneous alternariosis is a rare condition, more frequently presented in immunocompromised patients, which usually requires long courses of systemic antifungals that may interact with other medications.
Mar García-García +17 more
core +1 more source
Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
Advanced Science, EarlyView.Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang +9 more
wiley +1 more source
Minimal inhibitory concentrations of antifungals in A. fumigatus mutant strains.
, 2017 Minimal inhibitory concentrations of antifungals in A. fumigatus mutant strains.
Susumu Kawamoto (47745) +11 more
core +1 more source
MOF‐Derived Cu‐TiO2/Alginate Micromotors for Buoyancy‐Regulated 3D Motion
Advanced Science, EarlyView.In this work, cyanobacteria‐inspired sodium alginate (SA)/Cu‐TiO2/Fe3O4 hydrogel micromotors generate and encapsulate O2 microvesicles upon light irradiation, enabling buoyancy‐mediated Z‐axis upward migration and surface enrichment at the light‐exposed water‐air surface.
Wei Zou +7 more
wiley +1 more source
Advanced Science, EarlyView.In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang +8 more
wiley +1 more source
Advanced Science, EarlyView.Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala +15 more
wiley +1 more source
Contact dermatitis from topical imidazole antifungals: 15 new cases.
, 1989 Contact allergy from topical imidazole antifungals is seldom reported. 15 such cases, over a 12-year period, are reported here. Results are discussed particularly with regard to imidazole cross-reactions and to sensitization to topicals combining ...
Tennstedt, Dominique, Jelen, G.
core
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
, 2010 International audienceCandida albicans can form biofilms that exhibit elevated intrinsic resistance to various antifungal agents, in particular azoles and polyenes.
d'Enfert, Christophe +2 more
core +1 more source