Results 91 to 100 of about 1,112,551 (312)

Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1

, 2012
peer-reviewedViruses establishing persistent latent infections have evolved various mechanisms to avoid immune surveillance. The Epstein-Barr virus-encoded nuclear antigen, EBNA1, expressed in all EBV-associated malignancies, modulates its own protein ...
David J Lynn, Judy T Tellam, Rajiv Khanna, David J. Lynn (107188), Lea Lekieffre, Lynn, David J, Khanna, Rajiv, Judy T. Tellam (107182), Zhong, Jie, Jie Zhong (39213), Tellam, Judy T, Jie Zhong, Rajiv Khanna (107190), Lea Lekieffre (107185), Lekieffre, Lea   +14 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression. [PDF]

, 2012
The Epstein-Barr Virus (EBV) -encoded EBNA2 protein, which is essential for the in vitro transformation of B-lymphocytes, interferes with cellular processes by binding to proteins via conserved sequence motifs.
Stephanie Barth, Neuenkirchen, N., Alfredo Mamiani (146650), Grässer, Friedrich A., Ostareck-Lederer, Antje, Leonhardt, Heinrich, Nils Neuenkirchen (146673), Fischer, Utz, Bodo Moritz, Friedrich A Grässer, Wen Deng, Masouris, Ilias, Barth, Stephanie, Fischer, U., Hennard, C., Christian Cassel, Neuenkirchen, Nils, Utz Fischer (146680), Utz Fischer, Ute Stober-Grässer (146645), Elfriede Noessner (146689), Noessner, Elfriede, Henrik Gross (146622), Bodo Moritz (146655), Dirk Ostareck, Mamiani, Alfredo, Stephanie Barth (145387), Nößner, E., Alfredo Mamiani, Ostareck, Dirk, Christine Hennard (146627), Christian Cassel (146638), Moritz, Bodo, Antje Ostareck-Lederer, Elfriede Noessner, Deng, Wen, Gross, H., Christine Hennard, Ostareck, Dirk H., Antje Ostareck-Lederer (146668), Dirk Ostareck (146662), Heinrich Leonhardt (18589), Henrik Gross, Stober-Grässer, U., Masouris, I., Friedrich A. Grässer (145412), Kremmer, E., Wen Deng (123626), Grässer, F.A., Kremmer, Elisabeth, Cassel, C., Deng, W., Ilias Masouris (146632), Ilias Masouris, Ostareck-Lederer, A., Mamiani, A., Heinrich Leonhardt, Gross, Henrik, Moritz, B., Nils Neuenkirchen, Barth, S., Ostareck, D., Cassel, Christian, Stober-Grässer, Ute, Elisabeth Kremmer (17351), Ute Stober-Grässer, Elisabeth Kremmer, Leonhardt, H., Hennard, Christine   +68 more
core   +1 more source

Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen

Journal of Nanobiotechnology, 2016
Background Zinc oxide nanoparticle (ZNP) has been applied in various biomedical fields. Here, we investigated the usage of ZNP as an antigen carrier for vaccine development by combining a high affinity peptide to ZNP.
Na-Young Ha, Hyun Mu Shin, Prashant Sharma, Hyun Ah Cho, Chan-Ki Min, Hong-il Kim, Nguyen Thi Hai Yen, Jae-Seung Kang, Ik-Sang Kim, Myung-Sik Choi, Young Keun Kim, Nam-Hyuk Cho   +11 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A study of the effects of salt and of pH on precipitation of Antigen-antibody compounds [PDF]

, 1965
Tobacco mosaic virus (TMV) combines with its homologous antibody to much the same extent irrespective of whether or not salt is present, but without salt the complex not only fails to precipitate, but the virus particles do not aggregate.
Kleczkowski, A.
core  

Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens [PDF]

, 2015
Malaria is a major global cause of deaths and a vaccine is urgently needed.; We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled them in different ways using surface plasmon resonance (SPR) and ...
Stanisic, Danielle, Kironde, Fred, Danielle I. Stanisic, Anders, Robin F, Reddy, Sreenivasulu B, Persson, Kristina, Sreenivasulu B. Reddy, Cross, Nadia, Mats Wahlgren, Anders, Robin F., Cross, N, Beeson, James G, Wahlgren, M, Senn, Nicolas, Senn, N, Nicolas Senn, Kristina E.M. Persson, Reddy, SB, Stanisic, DI, Wahlgren, Mats, Nadia Cross, Fred Kironde, Beeson, JG, Persson, KEM, Mueller, Ivo, Reddy, Sreenivasulu B., Ivo Mueller, Peter M. Siba, Kironde, F, Siba, Peter M, Mueller, I, Siba, PM, Stanisic, Danielle I, Stanisic, Danielle I., Persson, Kristina,, Robin F. Anders, James G. Beeson, Siba, Peter M., Persson, Kristina E. M., Lund University., Beeson, James G., Anders, RF   +41 more
core   +1 more source

De novo design of epitope-specific antibodies via a structure-driven computational workflow

Nature Communications
Accurate modeling of antibody-antigen complex structures holds significant potential for advancing biomedical research and the design of therapeutic antibodies.
Fandi Wu, Yu Zhao, JiaXiang Wu, Biaobin Jiang, Bing He, Longkai Huang, Chenchen Qin, Yang Xiao, Fan Yang, Rubo Wang, Ningqiao Huang, Huaxian Jia, Yuyi Liu, Houtim Lai, Tingyang Xu, Fang Wang, Zihan Wu, Yidong Song, Shaoning Li, Wei Liu, Yu Rong, Peilin Zhao, Jianhua Yao   +22 more
doaj   +1 more source

Sequence-based engineering of pH-sensitive antibodies for tumor targeting or endosomal recycling applications

mAbs
The engineering of pH-sensitive therapeutic antibodies, particularly for improving effectiveness and specificity in acidic solid-tumor microenvironments, has recently gained traction.
Wanlei Wei, Traian Sulea
doaj   +1 more source

TEKNIK IMUNOHISTOKIMIA SEBAGAI PENDETEKSI ANTIGEN SPESIFIK PENYAKIT INFEKSI

Journal of Dentistry Indonesia, 2015
Infections may be caused by bacteria, viruses, fungi, and parasites. The diagnosis can be established on the basis of signs and symptoms, should be representative of the disease process, and should be obtainal before drug administration. Diagnosis may be
Yani Rahayu, Elza Auerkari
doaj   +1 more source