Results 21 to 30 of about 2,572,697 (149)

SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses

npj Vaccines, 2021
The emergence of variants of concern, some with reduced susceptibility to COVID-19 vaccines underscores consideration for the understanding of vaccine design that optimizes induction of effective cellular and humoral immune responses.
Joshua M. Carmen, Shikha Shrivastava, Zhongyan Lu, Alexander Anderson, Elaine B. Morrison, Rajeshwer S. Sankhala, Wei-Hung Chen, William C. Chang, Jessica S. Bolton, Gary R. Matyas, Nelson L. Michael, M. Gordon Joyce, Kayvon Modjarrad, Jeffrey R. Currier, Elke Bergmann-Leitner, Allison M. W. Malloy, Mangala Rao   +16 more
doaj   +1 more source

Body Measurements and Body Condition Scoring in Bactrian Camels

Animals
Body measurements are used regularly to describe phenotypes or the weight of animals. However, little data describe the age effect on the different measurements.
Bernard Faye, Shynar Akhmetsadykova, Moldir Akhmetzhanova, Zauresh Bilal, Zhaidar Musayev, Gaukhar Konuspayeva   +5 more
doaj   +1 more source

Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal ColonSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: Most knowledge about gastrointestinal (GI)-tract dendritic cells (DC) relies on murine studies where CD103+ DC specialize in generating immune tolerance with the functionality of CD11b+/− subsets being unclear.
David Bernardo, Lydia Durant, Elizabeth R. Mann, Elizabeth Bassity, Enrique Montalvillo, Ripple Man, Rakesh Vora, Durga Reddi, Fahri Bayiroglu, Luis Fernández-Salazar, Nick R. English, Simon T.C. Peake, Jon Landy, Gui H. Lee, George Malietzis, Yi Harn Siaw, Aravinth U. Murugananthan, Phil Hendy, Eva Sánchez-Recio, Robin K.S. Phillips, Jose A. Garrote, Paul Scott, Julian Parkhill, Malte Paulsen, Ailsa L. Hart, Hafid O. Al-Hassi, Eduardo Arranz, Alan W. Walker, Simon R. Carding, Stella C. Knight   +29 more
doaj   +1 more source

Dendritic Cells and Their Multiple Roles during Malaria Infection

Journal of Immunology Research, 2016
Dendritic cells (DCs) play a central role in the initiation of adaptive immune responses, efficiently presenting antigens to T cells. This ability relies on the presence of numerous surface and intracellular receptors capable of sensing microbial ...
Kelly N. S. Amorim, Daniele C. G. Chagas, Fernando B. Sulczewski, Silvia B. Boscardin   +3 more
doaj   +1 more source

Detection of intestinal parasites by different methods in our type 2 diabetic patients

Acta Medica Alanya, 2022
Aim: Long term persistently high blood glucose levels result in various complications and conditions in diabetic patients. One of them is gastrointestinal disorders and the other is increased risk of infectious diseases like parasitosis.
Müge Özsan Yılmaz
doaj   +1 more source

Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota

Mediators of Inflammation, 2013
Background. Dendritic cells regulate immune responses to microbial products and play a key role in ulcerative colitis (UC) pathology. We determined the immunomodulatory effects of probiotic strain Lactobacillus casei Shirota (LcS) on human DC
Elizabeth R. Mann, Jialu You, Verena Horneffer-van der Sluis, David Bernardo, Hafid Omar Al-Hassi, Jon Landy, Simon T. Peake, Linda V. Thomas, Cheng T. Tee, Gui Han Lee, Ailsa L. Hart, Parveen Yaqoob, Stella C. Knight   +12 more
doaj   +1 more source

A novel pan-proteome array for high-throughput profiling of the humoral response to Treponema pallidum

iScience
Summary: Given the resurgence of syphilis, research endeavors to improve current assays for serological diagnosis and management of this disease are a priority.
Joseph J. Campo, Emily Romeis, Amit Oberai, Jozelyn V. Pablo, Christopher Hung, Andy A. Teng, Adam D. Shandling, Amber Phan, Austin M. Haynes, Lorenzo Giacani   +9 more
doaj   +1 more source

Genomic and panproteomic analysis of the development of infant immune responses to antigenically-diverse pneumococci

Nature Communications
Streptococcus pneumoniae (pneumococcus) is a nasopharyngeal commensal and respiratory pathogen. This study characterises the immunoglobulin G (IgG) repertoire recognising pneumococci from birth to 24 months old (mo) in a prospectively-sampled cohort of ...
Nicholas J. Croucher, Joseph J. Campo, Timothy Q. Le, Jozelyn V. Pablo, Christopher Hung, Andy A. Teng, Claudia Turner, François Nosten, Stephen D. Bentley, Xiaowu Liang, Paul Turner, David Goldblatt   +11 more
doaj   +1 more source

Multiple Regions Drive Hepatitis Delta Virus Proliferation and Are Therapeutic Targets

Frontiers in Microbiology, 2022
Hepatitis Delta Virus (HDV) is the smallest mammalian single-stranded RNA virus. It requires host cells and hepatitis B virus (HBV) to complete its unique life cycle.
Jun Zi, Xiuzhu Gao, Juan Du, Hongqin Xu, Junqi Niu, Xiumei Chi   +5 more
doaj   +1 more source

Protein-specific immune response elicited by the Shigella sonnei 1790GAHB GMMA-based candidate vaccine in adults with varying exposure to Shigella

mSphere
Shigella is a leading cause of diarrheal morbidity and mortality in young children from low- and middle-income countries. Here, we aimed to verify the ability of the generalized modules for membrane antigens (GMMA)-based Shigella sonnei candidate vaccine
Arlo Z. Randall, Valentino Conti, Usman Nakakana, Xiaowu Liang, Andy A. Teng, Antonio Lorenzo Di Pasquale, Melissa Kapulu, Robert Frenck, Odile Launay, Pietro Ferruzzi, Antonella Silvia Sciré, Elisa Marchetti, Christina Obiero, Jozelyn V. Pablo, Joshua Edgar, Philip Bejon, Adam D. Shandling, Joseph J. Campo, Angela Yee, Laura B. Martin, Audino Podda, Francesca Micoli   +21 more
doaj   +1 more source