Results 21 to 30 of about 3,861,164 (348)

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

Journal of Immunology, 1984
The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. The aim of the present investigation was to clarify whether the Ki-67 nuclear antigen is restricted in its expression to certain phases of the cell cycle.
J. Gerdes, H. Lemke, H. Baisch, H. Wacker, U. Schwab, H. Stein   +5 more
semanticscholar   +1 more source

B lymphocytes secrete antigen-presenting vesicles

Journal of Experimental Medicine, 1996
Antigen-presenting cells contain a specialized late endocytic compartment, MIIC (major histocompatibility complex [MHC] class II- enriched compartment), that harbors newly synthesized MHC class II molecules in transit to the plasma membrane. MIICs have a
G. Raposo, H. Nijman, W. Stoorvogel, R. Liejendekker, C. Harding, C. Melief, H. Geuze   +6 more
semanticscholar   +1 more source

SARS-CoV-2 spike-ferritin-nanoparticle adjuvanted with ALFQ induces long-lived plasma cells and cross-neutralizing antibodies

npj Vaccines, 2023
This study demonstrates the impact of adjuvant on the development of T follicular helper (Tfh) and B cells, and their influence on antibody responses in mice vaccinated with SARS-CoV-2-spike-ferritin-nanoparticle (SpFN) adjuvanted with either Army ...
Shikha Shrivastava, Joshua M. Carmen, Zhongyan Lu, Shraddha Basu, Rajeshwer S. Sankhala, Wei-Hung Chen, Phuong Nguyen, William C. Chang, Jocelyn King, Courtney Corbitt, Sandra Mayer, Jessica S. Bolton, Alexander Anderson, Isabella Swafford, Guillermo D. Terriquez, Hung V. Trinh, Jiae Kim, Ousman Jobe, Dominic Paquin-Proulx, Gary, R. Matyas, Gregory D. Gromowski, Jeffrey R. Currier, Elke Bergmann-Leitner, Kayvon Modjarrad, Nelson L. Michael, M. Gordon Joyce, Allison M. W. Malloy, Mangala Rao   +27 more
doaj   +1 more source

Tuning the Antigen Density Requirement for CAR T Cell Activity.

Cancer Discovery, 2020
Insufficient reactivity against cells with low antigen density has emerged as an important cause of CAR resistance. Little is known about factors that modulate the threshold for antigen recognition. We demonstrate that CD19 CAR activity is dependent upon
R. Majzner, Skyler P Rietberg, E. Sotillo, Rui Dong, Vipul T. Vachharajani, Louai Labanieh, J. Myklebust, Meena Kadapakkam, Evan W. Weber, Aidan M Tousley, R. Richards, S. Heitzeneder, S. Nguyen, V. Wiebking, J. Theruvath, Rachel C. Lynn, P. Xu, A. Dunn, R. Vale, C. Mackall   +19 more
semanticscholar   +1 more source

Preparation and evaluation of Salmonella Enteritidis antigen conjugated with nanogold for screening of poultry flocks [PDF]

Veterinary World, 2017
Aim: The present work aimed to develop lateral flow immunochromatographic strip (ICS) test for detection of Salmonella Enteritidis (SE) specific antibodies in chicken sera.
Hazem Mohammed Ibrahim, Rafik Hamed Sayed, Wafaa Ragab Abdel-Aziz, Rafik Tawfik Soliman   +3 more
doaj   +1 more source

Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Frontiers in Immunology, 2022
Co-stimulation is critical to the function of chimeric antigen receptor (CAR) T-cells. Previously, we demonstrated that dual co-stimulation can be effectively harnessed by a parallel (p)CAR architecture in which a CD28-containing second generation CAR is
Leena Halim, Kushal K. Das, Daniel Larcombe-Young, Adam Ajina, Andrea Candelli, Reuben Benjamin, Reuben Benjamin, Richard Dillon, Richard Dillon, David M. Davies, John Maher, John Maher, John Maher, John Maher   +13 more
doaj   +1 more source

Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination

eLife, 2018
Pneumococcal whole cell vaccines (WCVs) could cost-effectively protect against a greater strain diversity than current capsule-based vaccines. Immunoglobulin G (IgG) responses to a WCV were characterised by applying longitudinally-sampled sera, available
Joseph J Campo, Timothy Q Le, Jozelyn V Pablo, Christopher Hung, Andy A Teng, Hervé Tettelin, Andrea Tate, William P Hanage, Mark R Alderson, Xiaowu Liang, Richard Malley, Marc Lipsitch, Nicholas J Croucher   +12 more
doaj   +1 more source

SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses

npj Vaccines, 2021
The emergence of variants of concern, some with reduced susceptibility to COVID-19 vaccines underscores consideration for the understanding of vaccine design that optimizes induction of effective cellular and humoral immune responses.
Joshua M. Carmen, Shikha Shrivastava, Zhongyan Lu, Alexander Anderson, Elaine B. Morrison, Rajeshwer S. Sankhala, Wei-Hung Chen, William C. Chang, Jessica S. Bolton, Gary R. Matyas, Nelson L. Michael, M. Gordon Joyce, Kayvon Modjarrad, Jeffrey R. Currier, Elke Bergmann-Leitner, Allison M. W. Malloy, Mangala Rao   +16 more
doaj   +1 more source

Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.

Journal of Immunology, 1972
A sensitive and simple method for the quantitative determination of antibodies is reported. Tubes coated with antigen are incubated with antiserum followed by an enzyme-labeled preparation of anti-immunoglobulin. The enzyme remaining in the tubes after
E. Engvall, P. Perlmann
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source