Results 41 to 50 of about 2,938,954 (317)

Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure

Medičnì Perspektivi, 2021
During the individual development and exposure to infectious agents of the organism, the structural components of the thyroid gland can change significantly.
O.V. Fedosieieva
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1

, 2012
peer-reviewedViruses establishing persistent latent infections have evolved various mechanisms to avoid immune surveillance. The Epstein-Barr virus-encoded nuclear antigen, EBNA1, expressed in all EBV-associated malignancies, modulates its own protein ...
David J Lynn, Judy T Tellam, Rajiv Khanna, David J. Lynn (107188), Lea Lekieffre, Lynn, David J, Khanna, Rajiv, Judy T. Tellam (107182), Zhong, Jie, Jie Zhong (39213), Tellam, Judy T, Jie Zhong, Rajiv Khanna (107190), Lea Lekieffre (107185), Lekieffre, Lea   +14 more
core   +1 more source

Presentation of CMV immediate-early antigen to cytolytic T lymphocytes is selectively prevented by viral genes expressed in the early phase [PDF]

, 1989
The regulation of antigen processing and presentation to MHC class I-restricted cytolytic T lymphocytes was studied in cells infected with murine cytomegalovirus. Recognition by cytolytic T lymphocytes of the phosphoprotein pp89, the immunodominant viral
Reddehase, Matthias J., Del Val, Margarita, Münch, Konrad, Koszinowski, Ulrich H., Margarita Del Val, Konrad Münch, Matthias J. Reddehase, Ulrich H. Koszinowski   +7 more
core   +1 more source

Immune and Oxidative Response against Sonicated Antigen of Mycoplasma capricolum subspecies capripneumonia—A Causative Agent of Contagious Caprine Pleuropneumonia

Microorganisms, 2022
Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted,
Rather Izhar Ul Haq, Oveas Rafiq Parray, Qurat Ul Ain Nazir, Riyaz Ahmed Bhat, Showkat Ahmad Shah, Majid Shafi Kawoosa, Ali A. Rabaan, Mohammed Aljeldah, Basim R. Al Shammari, Mohammed S. Almogbel, Nada Alharbi, Reem Alrashoudi, Amal A. Sabour, Rana A. Alaeq, Maha A. Alshiekheid, Saleh A. Alshamrani, Aqel Albutti, Ameen S.S. Alwashmi, Kuldeep Dhama, Mohd. Iqbal Yatoo   +19 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Cloning of the Complete Gene for Carcinoembryonic Antigen [PDF]

, 1990
Carcinoembryonic antigen (CEA) is a widely used tumor marker, especially in the surveillance of colonic cancer patients. Although CEA is also present in some normal tissues, it is apparently expressed at higher levels in tumorous tissues than in ...
Schrewe, Heinrich, Bona, Marion, Zimmermann, Wolfgang, Shively, John E., Hassauer, Martin, Hefta, Laura J. F., Maruya, Aiko, Thompson, John A., Kleist, Sabine von   +8 more
core  

Field comparison of circulating antibody assays versus circulating antigen assays for the detection of Schistosomiasis japonica in endemic areas of China [PDF]

, 2014
Schistosomiasis remains a serious public health problem in affected countries, and routine, highly sensitive and cost-effective diagnostic methods are lacking.
Peter Steinmann, Hao Li, Tian, Li-Guang, Li, Hao, Cai, Yu-Chun, Yang Zhou, Jia-Xu Chen, Xu, Jun-Fang, Yan Lu, Li-Guang Tian, Ling-Ling Zhang, Yu-Chun Cai, Yan-Hong Chu, Steinmann, Peter, Chu, Yan-Hong, Chen, Jia-Xu, Chen, Mu-Xin, Lu, Yan, Zhou, Yang, Mu-Xin Chen, Zhang, Ling-Ling, Shao-Hong Chen, Chen, Shao-Hong, Jun-Fang Xu   +23 more
core   +1 more source

Genomic and panproteomic analysis of the development of infant immune responses to antigenically-diverse pneumococci

Nature Communications
Streptococcus pneumoniae (pneumococcus) is a nasopharyngeal commensal and respiratory pathogen. This study characterises the immunoglobulin G (IgG) repertoire recognising pneumococci from birth to 24 months old (mo) in a prospectively-sampled cohort of ...
Nicholas J. Croucher, Joseph J. Campo, Timothy Q. Le, Jozelyn V. Pablo, Christopher Hung, Andy A. Teng, Claudia Turner, François Nosten, Stephen D. Bentley, Xiaowu Liang, Paul Turner, David Goldblatt   +11 more
doaj   +1 more source

A novel pan-proteome array for high-throughput profiling of the humoral response to Treponema pallidum

iScience
Summary: Given the resurgence of syphilis, research endeavors to improve current assays for serological diagnosis and management of this disease are a priority.
Joseph J. Campo, Emily Romeis, Amit Oberai, Jozelyn V. Pablo, Christopher Hung, Andy A. Teng, Adam D. Shandling, Amber Phan, Austin M. Haynes, Lorenzo Giacani   +9 more
doaj   +1 more source