Results 61 to 70 of about 3,174,163 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Serotyping and Cross-Reactivity’s Between Different Pseudomonas aeruginosa Isolates Prevalent in Iran

Iranian Journal of Microbiology, 2010
Background and Objectives: 300 Pseudomonas aeruginosa strains were isolated from hospitalized patients in Iran. Using international antigenic typing system (IATS) antibodies, all strains were classified into 16 serotypes while serotype 14 was not ...
H Ahmadi, S Malekian, B Tabaraie, D Norouzian, F Poormirza-gholi, M Nejati, MH Hedayati, MR Beik Mohammadi, A Behnoodi, M Izadpanahi   +9 more
doaj  

Modeling growth of Lactobacillus helveticus and Kluyveromyces marxianus isolated from fermented camel milk (shubat)

Frontiers in Microbiology
Shubat is a traditional fermented camel milk beverage in which lactic acid bacteria and yeasts jointly determine fermentation behavior, but the kinetic properties of autochthonous strains remain insufficiently characterized. This study aimed to model the
Aikerim Ospanova, Aikerim Ospanova, Askhat Khalbayev, Askhat Khalbayev, Shynar Akhmetsadykova, Nazerke Begdildayeva, Zauresh Bilal, Zauresh Bilal, Arailym Akhatzhanova, Arailym Akhatzhanova, Marko Vinceković, Askar Kondybayev, Askar Kondybayev   +12 more
doaj   +1 more source

Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal ColonSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: Most knowledge about gastrointestinal (GI)-tract dendritic cells (DC) relies on murine studies where CD103+ DC specialize in generating immune tolerance with the functionality of CD11b+/− subsets being unclear.
David Bernardo, Lydia Durant, Elizabeth R. Mann, Elizabeth Bassity, Enrique Montalvillo, Ripple Man, Rakesh Vora, Durga Reddi, Fahri Bayiroglu, Luis Fernández-Salazar, Nick R. English, Simon T.C. Peake, Jon Landy, Gui H. Lee, George Malietzis, Yi Harn Siaw, Aravinth U. Murugananthan, Phil Hendy, Eva Sánchez-Recio, Robin K.S. Phillips, Jose A. Garrote, Paul Scott, Julian Parkhill, Malte Paulsen, Ailsa L. Hart, Hafid O. Al-Hassi, Eduardo Arranz, Alan W. Walker, Simon R. Carding, Stella C. Knight   +29 more
doaj   +1 more source

Non-HLA Antibodies in Kidney Transplantation: Immunity and Genetic Insights

Biomedicines, 2022
The polymorphic human leukocyte antigen (HLA) system has been considered the main target for alloimmunity, but the non-HLA antibodies and autoimmunity have gained importance in kidney transplantation (KT).
Bogdan Marian Sorohan, Cătălin Baston, Dorina Tacu, Cristina Bucșa, Corina Țincu, Paula Vizireanu, Ioanel Sinescu, Ileana Constantinescu   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Physicochemical and FTIR-ATR Spectroscopic Characterization of Lipid Deterioration in Raw Horse Mesenteric Fat Under Stress Storage Conditions

Biology
Horse mesenteric fat is a culturally significant and nutritionally valuable food product in Central Asia, yet the kinetics of its oxidative and hydrolytic deterioration under sub-optimal storage conditions remain poorly characterized.
Moldir Nurseitova, Meruert Syzdyk, Xenia Dronova, Elizaveta Chuvashova, Sanimay Koshieva, Yerkin Massanov, Kuanish Syman, Gaukhar Konuspayeva, Bernard Faye, Nurlan Akhmetsadykov   +9 more
doaj   +1 more source

Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota

Mediators of Inflammation, 2013
Background. Dendritic cells regulate immune responses to microbial products and play a key role in ulcerative colitis (UC) pathology. We determined the immunomodulatory effects of probiotic strain Lactobacillus casei Shirota (LcS) on human DC
Elizabeth R. Mann, Jialu You, Verena Horneffer-van der Sluis, David Bernardo, Hafid Omar Al-Hassi, Jon Landy, Simon T. Peake, Linda V. Thomas, Cheng T. Tee, Gui Han Lee, Ailsa L. Hart, Parveen Yaqoob, Stella C. Knight   +12 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source