The evolution of humoral immune responses to past and novel influenza virus strains gives evidence for antigenic seniority [PDF]
Frontiers in Immunology, 2022 The high genetic and antigenic variability of influenza virus and the repeated exposures of individuals to the virus over time account for the human immune responses toward this pathogen to continuously evolve during the lifespan of an individual ...
Anke Huckriede, Rebecca Jane Cox
exaly +9 more sources
Evidence for Antigenic Seniority in Influenza A (H3N2) Antibody Responses in Southern China [PDF]
PLoS Pathogens, 2012 A key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response.
Gavin Jd Smith, Yi Guan, Steven Riley
exaly +8 more sources
No evidence of antigenic seniority in hemagglutinin specific antibody responses after adjuvanted pandemic 2009 influenza vaccination [PDF]
Vaccine: X, 2019 Influenza is a contagious respiratory illness caused by the influenza virus. The pandemic outbreak of influenza A H1N1 in 2009 (H1N1pdm09) gave us a unique opportunity to study humoral immune responses to a novel influenza vaccine strain.
Rebecca Jane Cox, Florian Krammer
exaly +6 more sources
Leveraging antigenic seniority for maternal vaccination to prevent mother-to-child transmission of HIV-1 [PDF]
npj Vaccines, 2022 The development of a maternal HIV vaccine to synergize with current antiretroviral drug prophylaxis can overcome implementation challenges and further reduce mother-to-child transmission (MTCT) of HIV.
Ashley N. Nelson +18 more
doaj +4 more sources
Immune imprinting: The persisting influence of the first antigenic encounter with rapidly evolving viruses [PDF]
Human Vaccines and ImmunotherapeuticsImmune imprinting is a phenomenon that stems from the fundamentals of immunological memory. Upon recurrent exposures to an evolving pathogen, the immune system must weigh the benefits of rapidly recalling established antibody repertoires with greater ...
Curtis Cooper +2 more
exaly +4 more sources
Antigenic Site Immunodominance Redirection Following Repeat Variant Exposure
Viruses, 2022 Human norovirus is a leading cause of acute gastroenteritis, driven by antigenic variants within the GII.4 genotype. Antibody responses to GII.4 vaccination in adults are shaped by immune memory.
Ralph Barıç +2 more
exaly +3 more sources
How immunity shapes the long-term dynamics of influenza H3N2. [PDF]
PLoS Computational BiologySince its emergence in 1968, influenza A H3N2 has caused yearly epidemics in temperate regions. While infection confers immunity against antigenically similar strains, new antigenically distinct strains that evade existing immunity regularly emerge ...
Oliver Eales +2 more
doaj +2 more sources
Low effectiveness of influenza vaccines vis-à-vis mechanism of protection by vaccines – potential causes and recommendations to improve control of influenza [PDF]
Frontiers in ImmunologyCurrent licensed influenza vaccines primarily protect by eliciting antibodies against the viral hemagglutinin (HA) glycoprotein, thereby blocking viral attachment and fusion with host cells.
Rajesh K. Gupta +2 more
doaj +2 more sources
Evaluating Memory B Cell Cross-Reactivity Between Ancestral and Future SARS-CoV-2 Variants—Evidence for Original Antigenic Sin [PDF]
VaccinesBackground: Despite the circulation of evolutionarily related cold-causing coronaviruses (CCCs) in the pre-COVID era, most individuals lacked pre-existing serum IgG and/or class-switched memory B cell (Bmem) reactivity for the SARS-CoV-2 Spike (S ...
Lingling Yao +3 more
doaj +2 more sources
Factors determining the outcomes of immune imprinting after repeated orthoflavivirus infections [PDF]
Frontiers in ImmunologyOrthoflaviviruses, a group of arthropod-borne viruses, represent a significant global health threat, with hundreds of millions of infections each year, often leading to severe clinical outcomes.
Gielenny M. Salem +5 more
doaj +2 more sources