Results 11 to 20 of about 233,497 (306)

Two Ways of Targeting a CD19 Positive Relapse of Acute Lymphoblastic Leukaemia after Anti-CD19 CAR-T Cells

Biomedicines, 2023
Background: Therapeutic options for CD19+ relapses after anti-CD19 CAR-T cells are still debated; second infusion of anti-CD19 CAR-T cells, therapeutic antibodies, or targeted therapies can be discussed.
Audrey Grain, Jocelyn Ollier, Thierry Guillaume, Patrice Chevallier, Baptiste Le Calvez, Marion Eveillard, Béatrice Clémenceau   +6 more
doaj   +2 more sources

Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers. [PDF]

, 2022
Chimeric antigen receptor (CAR)–modified T cells have revolutionized the treatment of CD19-positive hematologic malignancies. Although anti-CD19 CAR-engineered autologous T cells can induce remission in patients with B-cell acute lymphoblastic ...
Álvarez-Vallina, Luis, Rubio Pérez, Laura, Blanco, Belén   +2 more
core   +2 more sources

Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction [PDF]

, 2022
B cells exert antigen presenting functions at the crossroad between immune activation and tolerance induction, a fate notably governed by the B Cell Receptor (BCR) response regulator CD19/CD21 complex. This duality in B cells raises a particular interest
Broc, Sabine
core   +1 more source

Rejection of Experimental Hodgkins Lymphoma by T-cells Engineered with a CD19 Chimeric Antigen Receptor [PDF]

, 2012
T cells engineered to express chimeric receptors combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) internal domain for triggering cell activation are being used for immunotherapeutic targeting of tumour cells in a non-HLA ...
Cheadle, Eleanor, Johannessen, Ingolfur, Talbot, Simon, Cheadle, Eleanor J, Crawford, Dorothy, Gilham, David, Gilham, David E, Johannessen, Ingo, Swanson, Anna   +8 more
core   +1 more source

Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice with Cd19-Driven Cre Expression

Cells, 2022
Given the importance of B lymphocytes in inflammation and immune defense against pathogens, mice transgenic for Cre under the control of Cd19 promoter (Cd19Cre/+ mice) have been widely used to specifically investigate the role of loxP-flanked genes in B ...
Ying Zhao, Sai Zhao, Xiao-Yuan Qin, Ting-Ting He, Miao-Miao Hu, Zheng Gong, Hong-Min Wang, Fang-Yuan Gong, Xiao-Ming Gao, Jun Wang   +9 more
doaj   +1 more source

Antigen-specific cytokine profiles for pulmonary Mycobacterium avium complex disease stage diagnosis

Frontiers in Immunology, 2023
IntroductionControlling pulmonary Mycobacterium avium complex (MAC) disease is difficult because there is no way to know the clinical stage accurately. There have been few attempts to use cell-mediated immunity for diagnosing the stage.
Yoshiro Yamashita, Yoshiro Yamashita, Ikkoh Yasuda, Ikkoh Yasuda, Takeshi Tanaka, Toru Ikeda, Mayumi Terada, Masahiro Takaki, Yoshiko Tsuchihashi, Norichika Asoh, Yukiko Ohara, Shymaa Enany, Shymaa Enany, Haruka Kobayashi, Sohkichi Matsumoto, Konosuke Morimoto, Konosuke Morimoto   +16 more
doaj   +1 more source

Immunotherapeutic potential of blinatumomab-secreting γ9δ2 T Cells

Translational Oncology, 2023
Previous studies have explored the use of engineered blinatumomab-secreting autologous αβ T cells for CD19-targeted cancer therapy. To create a more flexible allogeneic delivery system, we utilized γ9δ2 T cells rather than αβ T cells in a similar ...
Shang-Ju Wu, Chien-Ting Lin, Cheng Hao Liao, Chun-Ming Lin   +3 more
doaj   +1 more source

Construction and Preclinical Evaluation of an Anti-CD19 Chimeric Antigen Receptor [PDF]

Journal of Immunotherapy, 2009
T cells can be engineered to express the genes of chimeric antigen receptors (CARs) that recognize tumor-associated antigens. We constructed and compared 2 CARs that contained a single chain variable region moiety that recognized CD19. One CAR contained the signaling moiety of the 4-1BB molecule and the other did not.
James N, Kochenderfer, Steven A, Feldman, Yangbing, Zhao, Hui, Xu, Mary A, Black, Richard A, Morgan, Wyndham H, Wilson, Steven A, Rosenberg   +7 more
openaire   +2 more sources

Mesenchymal stem cells promote leukaemic cells aberrant phenotype from B-cell acute lymphoblastic leukaemia

Hematology/Oncology and Stem Cell Therapy, 2013
BACKGROUND AND OBJECTIVES: The role of bone marrow-mesenchymal stem cells (BM-MSC) in leukae-mic cell control is controversial. The purpose of this work was to evaluate BM-MSC role regarding the viability, proliferation and immunophenotype of normal B ...
Viviana M Rodríguez-Pardo, José A Aristizabal, Diana Jaimes, Sandra M Quijano, Iliana de los Reyes, María Victoria Herrera, Julio Solano, Jean Paul Vernot   +7 more
doaj   +1 more source

Comparison of schistosoma mansoni soluble cercarial antigens and soluble egg antigens for serodiagnosing schistosome infections [PDF]

, 2011
A Schistosoma mansoni cercarial antigen preparation (cercarial transformation fluid – SmCTF) was evaluated for detection of anti-schistosome antibodies in human sera in 4 collaborating laboratories.
Dawson, E., Smith, H., Ji, Minjun, Mike Doenhoff, Emily Dawson, Claire Alexander, Gilis, Henk, van Gool, T., Cara Aitken (135264), Grant Spence, Aitken, Cara, Aitken, C., Bailey, W., Cara Aitken, Minjun Ji (135275), Spence, G., Spence, Grant, Henk Gilis, Tom van Gool, Doenhoff, M., Claire Alex, Wendi Bailey, Mike Doenhoff (135259), Gilis, H., Huw Smith, Doenhoff, Mike, van Gool, Tom, Dawson, Emily, Smith, Huw, Tom van Gool (135295), Henk Gilis (135283), Claire Alexander (20985), Minjun Ji, Bailey, Wendi, Grant Spence (135288), Alexander, C., Ji, M., Huw Smith (135256), Wendi Bailey (135270), Emily Dawson (135279), Alexander, Claire   +40 more
core   +2 more sources