Results 171 to 180 of about 233,740 (307)

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Beyond CAR-T: Preventing and Treating Relapse in B-Cell Haematological Malignancies. [PDF]

Cells
Canichella M, Abruzzese E, Cefalo M, Gianfelici V, Mazzone C, Trotta GE, Laureana R, Cupelli L, Del Principe MI.   +8 more
europepmc   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

Bortezomib‐based chemotherapy in Chinese pediatric patients with relapsed/refractory acute lymphoblastic leukemia: A single‐center retrospective study

Pediatric Investigation, EarlyView.
Bortezomib‐based chemotherapy achieved an 88.9% remission rate in Chinese pediatric patients with relapsed/refractory B‐cell acute lymphoblastic leukemia, enabling 62.5% of responders to bridge to transplantation, while T‐cell acute lymphoblastic leukemia showed no response.
Xingyu Zhao, Jian Wang, Liping Que, Dunhua Zhou, Jianpei Fang, Luhong Xu   +5 more
wiley   +1 more source

CAR-T cells and CAR-Treg cells for treatment of inflammatory bowel diseases. [PDF]

EULAR Rheumatol Open
Neurath MF.
europepmc   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

Development of a Novel Anti-CD19 Chimeric Antigen Receptor

Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this treatment available to our patients prompted us to develop a novel CART19 based on our own anti-CD19 antibody (A3B1), followed ...
Castellà, Maria, Boronat, Anna||, Martín-Ibáñez, Raquel, Rodríguez, Vanina, Suñé, Guillermo||, Caballero, Miguel||, Marzal, Berta, Pérez-Amill, Lorena||, Martín-Antonio, B.||, Castaño Cardoso, Julio||, Bueno, Clara||, Balagué, Olga||, González-Navarro, Europa Azucena||, Serra-Pages, Carles, Engel, Pablo||, Vilella, Ramon, Benítez Ribas, Daniel||, Ortiz-Maldonado, Valentín||, Cid, Joan||, Tabera, Jaime||, Canals, Josep M.||, Lozano, Miquel||, Baumann, Tycho||, Vilarrodona, Anna||, Trias, Esteve||, Campo, Elias||, Menéndez Bujan, Pablo||, Urbano Ispizua, Álvaro||, Yagüe, Jordi||, Pérez-Galán, Patricia||, Rives, Susana||, Delgado, Julio||, Juan, Manel||   +32 more
openaire   +1 more source

H2-O deficiency in B cells or dendritic cells drives retrovirus-neutralizing antibody responses. [PDF]

J Virol
Dobkin J, Fink R, Lietuvninkas HB, Golovkina TV, Denzin LK.   +4 more
europepmc   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

CD21 and CD19: how B cells sense antigen [PDF]

Clinical and Experimental Immunology, 1994
openaire   +1 more source