Results 281 to 290 of about 1,141,456 (326)

The CD34 Antigen: Structure, Biology, and Potential Clinical Applications

Journal of Hematotherapy, 1992
The diversity of function of mature circulating blood cells is reflected in their respective complements of cell-surface molecules and receptors. Although monoclonal antibodies have been instrumental in the identification and characterization of many cell-surface molecules on mature hematopoietic cells, the CD34 antigen represents to date, the only ...
D R, Sutherland, A, Keating
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Expression of CD34 antigen in testicular mixed germ cell tumor

Pathology International, 2003
The expression of CD34 was investigated in 14 cases of testicular mixed germ cell tumor to elucidate the relationship between its expression and histological patterns. Seven of 12 yolk sac tumor components were focally immunoreactive for anti‐CD34 antibody.
Shuji, Hamazaki, Shigeru, Okada
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Hematopoietic Stem Cell Antigen CD34: Role in Adhesion or Homing

Stem Cells and Development, 2006
CD34 is highly glycosylated surface antigen of enormous clinical utility in the identification, enumeration, and purification of engraftable lymphohematopoietic progenitors for transplantation. However, recently its importance in the specific marking of most immature hematopoietic stem/progenitor cells have been questioned by addressing long-term ...
Gurudutta U, Gangenahalli, Vimal K, Singh, Yogesh K, Verma, Pallavi, Gupta, Rakesh K, Sharma, Ramesh, Chandra, Pratibha M, Luthra   +6 more
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Significance of hematopoietic surface antigen CD34 in neuroblastoma prognosis and the genetic landscape of CD34-expressing neuroblastoma CSCs

Cell Biology and Toxicology, 2020
High-risk neuroblastoma (HR-NB) is branded with hematogenous metastasis, relapses, and dismal long-term survival. Intensification of consolidation therapy with tandem/triple autologous stem cell (SC) rescue (with bone marrow [BM]/peripheral blood [PB] CD34+ selection) after myeloablative chemotherapy has improved long-term survival.
Natarajan Aravindan, Dinesh Babu Somasundaram, Terence S. Herman, Sheeja Aravindan   +3 more
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Novel transcription factors in human CD34 antigen–positive hematopoietic cells

Blood, 2002
AbstractTranscription factors (TFs) and the regulatory proteins that control them play key roles in hematopoiesis, controlling basic processes of cell growth and differentiation; disruption of these processes may lead to leukemogenesis. Here we attempt to identify functionally novel and partially characterized TFs/regulatory proteins that are expressed
Ignatius, Gomes, Tiffany T, Sharma, Seby, Edassery, Noreen, Fulton, Brenton G, Mar, Carol A, Westbrook   +5 more
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Separation of CD34 positive cells and determinationof surface homing antigen

Current Medical Science, 2000
To study the differences in homing potential between bone marrow cells and umbilical blood cells, CD34 positive cells were obtained from bone marrow (BM) and umbilical blood (UB) by the direct cell separation with domestic immunomagnetic beads. The expression of the two adhesion molecules CD11a/CD18 and CD44 were examined.
L, Wang, P, Zou, Y, You
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Electron microscopy demonstration of CD34 antigen on progenitor pseudopodia

Experimental Hematology, 2000
Abstract Current theory predicts stem cells are CD34-negative, despite CD34 use for therapeutic progenitor purification. Expressed on early haemopoietic cells, it is implicated in cellular adhesion, and marrow stromal cell homing. There are 2 CD34 forms, one intracellularly truncated, hypothesised for adhesion alone, with the extended variant capable ...
C. Hayward-Costa, D. Pearce, R. Pettengell, N. Forraz, A. Davies, W. Edwards, C.P. McGuckin   +6 more
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The Prognostic Significance of the CD34 Antigen in Acute Myeloid Leukaemia

Leukemia & Lymphoma, 1992
The prognostic value of CD34 expression on leukaemic blast cells was assessed in 38 patients with acute myeloid leukaemia. Nineteen patients had more than 10% CD34 positive blast cells. Median survival for the CD34 positive patients was 125 days and for the CD34 negative patients the median survival has not yet been reached at day 575 (p = 0.06).
H, Myint, N P, Lucie
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The expression of the endothelial cell antigen CD34 in demyelinating disease

Neuropathology and Applied Neurobiology, 1996
In this study, the antigenic expression of CD34, a 110 kDa glycoprotein which is expressed on human haemopoletic cells and vascular endothelium, has been assessed in variety of neuropathological conditions, including infectious and demyelinating disease.
I V, Allen, S, McQuaid, J, McMahon, K, Crangle, R, McConnell   +4 more
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Decreased Expression of the Human Progenitor Cell Antigen (CD34) in Morphea

The American Journal of Dermatopathology, 1995
Morphea is an idiopathic disorder the hallmark of which is fibrosis of the skin. The regulatory factors resulting in the increased collagen production have not been determined. Within the dermis there are dendritic cells with possible immunological functions that express either the human progenitor cell antigen (CD34) or factor XIIIa ...
K, Skobieranda, K F, Helm
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