Results 91 to 100 of about 49,776 (318)
Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses [PDF]
, 2015 Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies.
arxiv +1 more source
Neoplasia Blástica de Células Dendríticas Plasmocitóides [PDF]
, 2013 Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor
Cabete, J +5 more
core
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Role of CD1A and HSP60 in the antitumoral response of oesophageal cancer
Oncology Reviews, 2011 Oesophageal cancer (OC) is one of the most common and severe forms of tumor. A wider knowledge of molecular mechanisms which lead to a normal epithelium becoming a neoplasm may reveal new strategies to improve treatment and outcome of this disease.
Simona Corrao +6 more
doaj +2 more sources
Integrating influenza antigenic dynamics with molecular evolution [PDF]
arXiv, 2013 Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains using the hemagglutination inhibition (HI) assay.
arxiv
Computational model for tumor response to adoptive cell transfer therapy [PDF]
arXiv, 2022 One of the barriers to the development of effective adoptive cell transfer therapies (ACT), specifically for genetically engineered T-cell receptors (TCRs), and chimeric antigen receptor (CAR) T-cells, is target antigen heterogeneity. It is thought that intratumor heterogeneity is one of the leading determinants of therapeutic resistance and treatment ...
arxiv
Vergleich dreier Ringversuche zur radioimmunologischen Thyrotropin-Bestimmung nach dem "Münchner Modell" [PDF]
, 1983 Peer ...
Habermann, J. +5 more
core +2 more sources
ACTA HISTOCHEMICA ET CYTOCHEMICA, 1994 Mucins are high molecular weight glycoproteins having oligosaccharides attached to serine or threonine residues of the core protein backbone. Synthesis and secretion of mucin are common features of glandular epithelial tissues. Alterations in the glycosylation of mucins have been described in cancer, however little is known about the expression of ...
openaire +3 more sources
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Sequence-Based Nanobody-Antigen Binding Prediction [PDF]
arXiv, 2023 Nanobodies (Nb) are monomeric heavy-chain fragments derived from heavy-chain only antibodies naturally found in Camelids and Sharks. Their considerably small size (~3-4 nm; 13 kDa) and favorable biophysical properties make them attractive targets for recombinant production.
arxiv