Results 201 to 210 of about 131,754 (303)

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Antibodies against cell adhesion molecules and neural structures in paraneoplastic neuropathies

Paraneoplastic neurological syndromes () are rare neurological disorders in which ectopic expression of neural antigens by a tumor results in an autoimmune attack against the nervous system.
Graus Ribas, Francesc, Diaz-Manera, Jordi, Illa, Isabel, Gallardo, Eduard, Martínez-Hernández, Eugenia, Araque, Josefa, Rojas-Garcia, Ricard, Universitat Autònoma de Barcelona, Querol, Luis, Siles, Ana M.   +9 more
core  

A conditional multi-signal validation framework for cancer immunotherapy: the adaptive anti-error biological system. [PDF]

Front Immunol
Kalondero EM.
europepmc   +1 more source

Application of Immunohistochemistry for Diagnosis of Neoplasms: Mucin Antigens Expression and Biological Behavior of Neoplasms.

ACTA HISTOCHEMICA ET CYTOCHEMICA, 1994
openaire   +2 more sources

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Identification and prioritisation of tumour antigen candidates from 79 glioblastoma transcriptomes. [PDF]

Cancer Immunol Immunother
Kert Š, Pižem J, Petrin S, Bošnjak M, Jerala M, Matjašič A, Zupan A.   +6 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Cutaneous Manifestations as a Sentinel of Colorectal Cancer: A Case Report. [PDF]

J Clin Med
Marinho B, Velho G, Santos MD.
europepmc   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Noncanonical Transcription and Splicing Shape the Colorectal Cancer Immunopeptidome in MSI and MSS Tumors. [PDF]

Mol Cell Proteomics
Courcelles M, Hardy MP, Durette C, Lanoix J, Minati R, Laverdure JP, Vincent K, Perreault C, Thibault P.   +8 more
europepmc   +1 more source