Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases.
Phanitchanat Phusuphitchayanan+6 more
doaj +1 more source
Malignant histiocytosis: A reassessment of cases formerly classified as histiocytic neoplasms and review of the literature [PDF]
Malignant histiocytosis (MH) and true histiocytic lymphoma (THL) are hematopoietic malignancies of the mononuclear phagocytic system distinguished from each other by clinical presentation and presumed cell of origin.
Egeler, R.M. (Maarten)+4 more
core +1 more source
The effects of symmetry on the dynamics of antigenic variation [PDF]
In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen. Using the example of a model of antigenic variation in malaria, we show how many of the observed dynamical regimes can be explained in terms of the symmetry of ...
arxiv +1 more source
Advancements in Chimeric Antigen Receptor T Cell Therapy for Hepatocellular Carcinoma [PDF]
Chimeric antigen receptor T cell (CAR-T) therapy nowadays symbolizes an innovative paradigm of neoplasm immunotherapy that employs genetic engineering techniques to empower T cells and make it have a capability to precisely identify tumor-associated ...
Zhao Xinyu
doaj +1 more source
A 74-year-old woman presented with a 30-day history of blisters and erosions in the oral cavity, trunk, and left eye conjunctival mucosa, also reporting a weight loss of 15 kg in the last 3 months.
Eleonora Quattri+9 more
doaj +1 more source
Immune myopathies with perimysial pathology: Clinical and laboratory features [PDF]
ObjectiveImmune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium.
Bucelli, Robert C, Pestronk, Alan
core +2 more sources
Mathematical models for order of mutation problem in myeloproliferative neoplasm: non-additivity and non-commutativity [PDF]
In some patients of myeloproliferative neoplasm, two genetic mutations can be found: JAK2 V617F and TET2. When one mutation is present or not, the other mutation has different effects on regulating gene expressions. Besides, when both mutations are present, the order of occurrence might make a difference.
arxiv
Growth stage dependent expression of MHC antigens on the canine transmissible venereal sarcoma.
Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family,
T. J. Yang, J. Chandler, S. Dunne-Anway
semanticscholar +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
Order-of-mutation effects on cancer progression: models for myeloproliferative neoplasm [PDF]
We develop a modeling framework for cancer progression that distinguishes the order of two possible mutations. Recent observations and information on myeloproliferative neoplasms are analyzed within our framework. In some patients with myeloproliferative neoplasms, two genetic mutations can be found, JAK2 V617F and TET2.
arxiv