Results 61 to 70 of about 131,754 (303)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effects of Immunomodulatory Cytokines on the Presentation of Tumor-Associated Antigens by Epidermal Langerhans Cells

, 1992
The recognition and presentation of tumor-associated antigens by cutaneous antigen-presenting cells (APC) may play an important role in the establishment of effective defense mechanisms against newly emerging tumors in the skin.
Bruvers, Sandra, Stephan Grabbe, Sandra Bruvers, Grabbe, Stephan, Granstein, Richard D, Richard D Granstein   +5 more
core   +1 more source

Unraveling the potential: mRNA therapeutics in oncology

Frontiers in Oncology
Messenger ribonucleic acid (mRNA) technology is a promising platform for cancer immunotherapy. Unlike traditional vaccines that prevent infectious diseases, mRNA’s role in oncology is to stimulate or enhance the immune response against tumor antigens ...
Karol Gawalski, Karol Gawalski, Weronika Przybyszewska, Weronika Przybyszewska, Jaromir Hunia, Jaromir Hunia, Alicja Gawalska, Aleksandra Rymarz   +7 more
doaj   +1 more source

Serum and Salivary Cea and Gica Levels in Oral Cavity Tumours

The International Journal of Biological Markers, 1988
The gastrointestinal cancer-associated antigen (GICA) is recognised by a monoclonal antibody in both serum and tissues ofpatients with neoplasm of the GI tract. This study compared the serum and saliva values of carcinoembryonic antigen (CEA) and GICA in
L. Negri, D. Pacchioni, F. Calabrese, S. Giacomasso, V. Mastromatteo, M. Fazio   +5 more
doaj   +1 more source

Follicular dendritic cell sarcoma with paraneoplatic pemphigus: Rare case and a brief review of literature

Indian Journal of Medical and Paediatric Oncology, 2013
Paraneoplastic pemphigus (PNP) is often a fatal autoimmune bullous disease characterized by severe stomatitis, polymorphous skin eruptions, and underlying neoplasms. We describe a patient with PNP associated with follicular dendritic cell sarcoma (FDCS),
Saphalta Baghmar, Sanjeev Kumar, S Dutta Gupta, Vinod Raina   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Tumor Markers in the Diagnosis, Monitoring and Therapy of Pancreatic Cancer: State of the Art

The International Journal of Biological Markers, 1995
The present review focuses on the utility of serum tumor markers in screening, diagnosis, prognosis and monitoring of pancreatic cancer. Serum determination of all tumor markers studied offers no help in screening or early diagnosis of pancreatic cancer.
M. Plebani, D. Basso, M.P. Panozzo, P. Fogar, G. Del Favero, R. Naccarato   +5 more
doaj   +1 more source

Aberrant T-cell antigen expression in a plasma cell neoplasm [PDF]

Blood, 2018
![Figure][1] A 76-year-old woman presented with a lytic lesion involving the right ilium. A targeted biopsy showed diffuse infiltrate of atypical, pleomorphic plasma cells (panel A; original magnification ×1000, hematoxylin and eosin stain), positive for CD138 (panel B ...
Smita, Patel, Bachir, Alobeid
openaire   +2 more sources