Results 31 to 40 of about 91,094 (312)

Immunization against rabies with plant-derived antigen

Proceedings of the National Academy of Sciences, 1998
We previously demonstrated that recombinant plant virus particles containing a chimeric peptide representing two rabies virus epitopes stimulate virus neutralizing antibody synthesis in immunized mice. We show here that mice immunized intraperitoneally or orally (by gastric intubation or by feeding on virus-infected spinach leaves) with engineered ...
A, Modelska, B, Dietzschold, N, Sleysh, Z F, Fu, K, Steplewski, D C, Hooper, H, Koprowski, V, Yusibov   +7 more
openaire   +3 more sources

Phytochemical-rich medicinal plant extracts suppress bacterial antigens-induced inflammation in human tonsil epithelial cells [PDF]

PeerJ, 2017
Background Pharyngitis is an inflammatory condition of the pharynx and associated structures commonly caused by the Group A streptococci (GAS). There is a growing interest in discovering plant-based anti-inflammatory compounds as potential alternatives ...
Niluni M. Wijesundara, Satvir Sekhon-Loodu, HP Vasantha Rupasinghe   +2 more
doaj   +2 more sources

Plant Viruses as Adjuvants for Next-Generation Vaccines and Immunotherapy

Vaccines, 2023
Vaccines are the cornerstone of infectious disease control and prevention. The outbreak of SARS-CoV-2 has confirmed the urgent need for a new approach to the design of novel vaccines.
Nikolai Nikitin, Yuri Vasiliev, Angelina Kovalenko, Ekaterina Ryabchevskaya, Olga Kondakova, Ekaterina Evtushenko, Olga Karpova   +6 more
doaj   +1 more source

Impact of Specific N-Glycan Modifications on the Use of Plant-Produced SARS-CoV-2 Antigens in Serological Assays

Frontiers in Plant Science, 2021
The receptor binding domain (RBD) of the SARS-CoV-2 spike protein plays a key role in the virus-host cell interaction, and viral infection. The RBD is a major target for neutralizing antibodies, whilst recombinant RBD is commonly used as an antigen in ...
Jennifer Schwestka, Julia König-Beihammer, Yun-Ji Shin, Ulrike Vavra, Nikolaus F. Kienzl, Clemens Grünwald-Gruber, Daniel Maresch, Miriam Klausberger, Elisabeth Laurent, Elisabeth Laurent, Maria Stadler, Gabriele Manhart, Jasmin Huber, Manuela Hofner, Klemens Vierlinger, Andreas Weinhäusel, Ines Swoboda, Christoph J. Binder, Wilhelm Gerner, Florian Grebien, Friedrich Altmann, Lukas Mach, Eva Stöger, Richard Strasser   +23 more
doaj   +1 more source

Plant-Produced Chimeric Hepatitis E Virus-like Particles as Carriers for Antigen Presentation

Viruses
A wide range of virus-like particles (VLPs) is extensively employed as carriers to display various antigens for vaccine development to fight against different infections. The plant-produced truncated variant of the hepatitis E virus (HEV) coat protein is
Eugenia S. Mardanova, Egor A. Vasyagin, Kira G. Kotova, Gergana G. Zahmanova, Nikolai V. Ravin   +4 more
doaj   +1 more source

Glycophenotypic alterations induced by Pteridium aquilinum in mice gastric mucosa: synergistic effect with Helicobacter pylori infection. [PDF]

PLoS ONE, 2012
The bracken fern Pteridium aquilinum is a plant known to be carcinogenic to animals. Epidemiological studies have shown an association between bracken fern exposure and gastric cancer development in humans.
Joana Gomes, Ana Magalhães, Ana S Carvalho, Gilberto E Hernandez, Suzanne L Papp, Steven R Head, Valérie Michel, Leonor David, Fátima Gärtner, Eliette Touati, Celso A Reis   +10 more
doaj   +1 more source

Hydroponic Treatment of Nicotiana benthamiana with Kifunensine Modifies the N-glycans of Recombinant Glycoprotein Antigens to Predominantly Man9 High-Mannose Type upon Transient Overexpression

Frontiers in Plant Science, 2018
Nicotiana benthamiana transient overexpression systems offer unique advantages for rapid and scalable biopharmaceuticals production, including high scalability and eukaryotic post-translational modifications such as N-glycosylation.
Sugata Roychowdhury, Young J. Oh, Hiroyuki Kajiura, Krystal T. Hamorsky, Krystal T. Hamorsky, Kazuhito Fujiyama, Nobuyuki Matoba, Nobuyuki Matoba, Nobuyuki Matoba   +8 more
doaj   +1 more source

Transgenic plants for animal health: plant-made vaccine antigens for animal infectious disease control [PDF]

Phytochemistry Reviews, 2008
A variety of plant species have been genetically modified to accumulate vaccine antigens for human and animal health and the first vaccine candidates are approaching the market. The regulatory burden for animal vaccines is less than that for human use and this has attracted the attention of researchers and companies, and investment in plant-made ...
Joensuu, J. J., Niklander-Teeri, V., Brandle, J. E.   +2 more
openaire   +2 more sources

Factors influencing transfusion-associated HLA sensitization in patients bridged to heart transplantation using ventricular assist device. [PDF]

, 2020
BackgroundBridging heart failure patients with mechanical ventricular assist devices (VAD) enables access to transplantation. However, VAD is associated with increased risk for anti-HLA antibodies associated with rejection of subsequent allografts ...
Adler, Eric, Elkind, Jae, Morris, Gerald P, Ostberg-Braun, Oscar, Silva Enciso, Jorge, Sobczyk, Juliana   +5 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source