Results 71 to 80 of about 91,094 (312)

Targeting of T/Tn antigens with a plant lectin to kill human leukemia cells by photochemotherapy.

PLoS ONE, 2011
Photochemotherapy is used both for solid tumors and in extracorporeal treatment of various hematologic disorders. Nevertheless, its development in oncology remains limited, because of the low selectivity of photosensitizers (PS) towards human tumor cells.
Guillaume Poiroux, Marguerite Pitié, Raphaël Culerrier, Elodie Lafont, Bruno Ségui, Els J M Van Damme, Willy J Peumans, Jean Bernadou, Thierry Levade, Pierre Rougé, Annick Barre, Hervé Benoist   +11 more
doaj   +1 more source

The relationship of site to transplantability [PDF]

, 1963
Thesis (M.A.)--Boston ...
Anderson, Leonard L.
core  

Plant-derived EpCAM antigen induces protective anti-cancer response

Cancer Immunology, Immunotherapy, 2007
Immunotherapy holds great promise for treatment of infectious and malignant diseases and might help to prevent the occurrence and recurrence of cancer. We produced a plant-derived tumor-associated colorectal cancer antigen EpCAM (pGA733) at high yields using two modern plant expression systems.
Brodzik, Robert, Spitsin, Sergei, Golovkin, Max, Bandurska, Katarzyna, Portocarrero, Carla, Okulicz, Monika, Steplewski, Zenon, Koprowski, Hilary   +7 more
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Production and characterization of nervous necrosis virus vaccine antigens in wild type and CRISPR/Cas9 genome edited Nicotiana benthamiana and edible crop lettuce Lactuca sativa

Aquaculture Reports
Aquaculture constitutes an important source of protein, essential omega-3 fatty acids and bioavailable micronutrients for humans. The increasing demand for aquatic food products has resulted in more intensive farming practices leading to negative impacts
Iva Andrasevic, Hang Su, Espen Rimstad, Jihong Liu Clarke   +3 more
doaj   +1 more source

Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope

Scientific Reports, 2017
Immunotoxins (ITs), which consist of antibodies conjugated to toxins, have been proposed as a treatment for cancer and chronic infections. To develop and improve the ITs, different toxins such as ricin, have been used, aiming for higher efficacy against ...
Mohammad Sadraeian, Francisco E. G. Guimarães, Ana P. U. Araújo, David K. Worthylake, Louis Jr. LeCour, Seth H. Pincus   +5 more
doaj   +1 more source

Garden-variety vaccines: antigens derived from transgenic plants

Expert Review of Vaccines, 2004
The discovery of new vaccines can result from deletion of virulence determinants from a specific pathogen or from identification of target antigens that stimulate a protective immune response. Vaccine development will become less empirical as applications of genomics, proteomics and reverse vaccinology are exploited, and new protective antigens will ...
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma

Frontiers in Pharmacology, 2019
Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials.
Claudia Robles-Planells, Claudia Robles-Planells, Sofia A. Michelson, Javier Mena, Daniela Escrig, Juan L. Rojas, Giselle Sanchez-Guerrero, Ronny Hernández, Carlos Barrera-Avalos, Carlos Barrera-Avalos, Leonel E. Rojo, Leonel E. Rojo, Daniela Sauma, Alexis M. Kalergis, Mónica Imarai, Mónica Imarai, Ricardo Fernández, Carolina A. Robles, Elías Leiva-Salcedo, Rocio Santander, Alejandro Escobar, Claudio Acuña-Castillo, Claudio Acuña-Castillo   +22 more
doaj   +1 more source

Functional characterization of infiltrating T lymphocytes in human hepatic allografts [PDF]

, 1986
We have employed recently developed techniques in T-cell culturing to study the nature and function of infiltrating hepatic allograft T cells. Using the rationale that intragraft T cells are activated during cell mediated damage to the allograft, we were
Adriana Zeevi, Ascher, Bernard, Bono, Brodsky, Brodsky, Brodsky, Burdick, Burdick, Cerilli, Depper, Fiche, Goyert, HancocK, Harty, Hayry, Hoshinaga, Houssin, Iwatsuki, Iwatsuki, Iwatsuki, Jake Demetris, Jeannet, John J. Fung, Kim, Kolbeck, Lampson, Marboe, Mayer, Moreau, Palacios, Paradis, Pober, Rene J. Duquesnoy, Roberts, Shaw, Shunzaburo Iwatsuki, Snover, Spits, Starzl, Steinmuller, Stelzer, Strassman, Thomas E. Starzl, Thompson, Thorley-Lawson, Tilney, van Es, Weintraub, Zeevi, Zeevi, Zeevi, Zeevi, Zeevi   +53 more
core   +1 more source