Results 241 to 250 of about 557,005 (309)

3D‐Printed Multidimensional Bionic Mg‐MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects

Advanced Healthcare Materials, EarlyView.
This study develops 3D‐printed Mg‐MC/PLGA scaffolds with varying Mg concentrations (0–20%). The 5% Mg scaffold shows optimal cytocompatibility, osteogenic activity in vitro, and significantly enhances bone regeneration in rabbits, improving bone volume and mechanical strength.
Shihang Liu, Shuai Zhou, Tingting Zou, Guangzhao Hou, Qian Xiao, Lin Li, Jianjun Yang, Wei Chen, Yingze Zhang, Hongzhi Lv   +9 more
wiley   +1 more source

Advantages of using complement components in preventive and therapeutic vaccine strategies for infectious and non-infectious diseases. [PDF]

J R Soc Interface
Firdaus NHW, Mallick B, Nandakumar KS, Shakya AK.   +3 more
europepmc   +1 more source

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source

Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells. [PDF]

Proc Natl Acad Sci U S A
Prota G, Berloffa G, Awad W, Vacchini A, Chancellor A, Schaefer V, Constantin D, Littler DR, Colombo R, Nosi V, Mori L, Rossjohn J, De Libero G.   +12 more
europepmc   +1 more source

Inhalability and Bioactivity of Spray‐Dried versus Pressurized Gas eXpanded Liquid Technology‐Processed Yeast Beta‐Glucan Microparticles for Anti‐Fibrotic Therapies

Advanced Healthcare Materials, EarlyView.
PGXTEC) liquid technology is utilized to develop highly respirable yeast beta‐glucan (YBG) microparticles for the treatment of pulmonary fibrosis. Compared to conventionally processed spray‐dried YBG, PGXTEC‐YBG exhibits greatly improved aerodynamic properties, enhanced pro‐fibrotic macrophage uptake, and effective downregulation of pro‐fibrotic ...
Nate Dowdall, Safaa Naiel, Quan Zhou, Pareesa Ali, Tamana Rubina Yousof, Emily Wong, Ricardo Couto, Byron Yépez, Bernhard Seifried, Paul Moquin, Rod Rhem, Myrna Dolovich, Martin Rainer Kolb, Kjetil Ask, Todd Hoare   +14 more
wiley   +1 more source

Nano/Micro-Enabled Modification and Innovation of Conventional Adjuvants for Next-Generation Vaccines. [PDF]

J Funct Biomater
Liu X, Yang X, Tao L, Li X, Chen G, Liu Q.   +5 more
europepmc   +1 more source

Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma

Advanced Healthcare Materials, EarlyView.
A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li, Jiahui Li, Hasan Al Faruque, Paul Shami, Birgit Knoechel, Jens Lohr, Douglas Sborov, Jiyuan Yang, Jindřich Kopeček   +8 more
wiley   +1 more source

Bivalent single-domain antibodies show potent mpox virus neutralization through M1R antigen. [PDF]

Commun Biol
Akazawa D, Shimojima M, Park ES, Okutani A, Virhuez-Mendoza M, Inoue Y, Hishiki T, Maeda K, Ebihara H, Takahashi Y, Watashi K.   +10 more
europepmc   +1 more source

A novel nanoparticle vaccine displaying multistage tuberculosis antigens confers protection in mice infected with H37Rv. [PDF]

NPJ Vaccines
Ding Y, Li Y, Wu Z, Zhou Y, Guo Y, Tian S, Yu R, Deng C, Wei R, Chen H, Li Y, Zhang X, Yu W, Jing C, Liu S, Qin L, Lyu M, Zou Y, Yao Y, Tan L, Wu S, Liu W, Chen X, Jin J.   +23 more
europepmc   +1 more source