Results 211 to 220 of about 243,841 (269)

Mucosal immunity and vaccination strategies: current insights and future perspectives. [PDF]

Mol Biomed
Zhang Z, Hong W, Zhang Y, Li X, Que H, Wei X.   +5 more
europepmc   +1 more source

A safe, T cell-inducing heterologous vaccine against elephant endotheliotropic herpesvirus in a proof-of-concept study. [PDF]

Nat Commun
Maehr T, Lopez J, Drake G, Ferreira FM, Fraser R, Mckown R, Kailath R, Morris S, Chambers A, Graves LP, Walker SL, Dastjerdi A, Edwards KL, Nakaya HI, Steinbach F.   +14 more
europepmc   +1 more source

Human CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader responses. [PDF]

J Exp Med
Stetsenko V, Gail DP, Reba SM, Suzart VG, Schauner R, Sandhu AK, Sette A, Haj Dezfulian M, Lindestam Arlehamn CS, Carpenter SM.   +9 more
europepmc   +1 more source

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Thymus dependence of viral antigens

Nature, 1975
AFTER exposure of animals to most antigens, formation of antibody by cells of the B lymphocyte lineage requires helper effects of T lymphocytes1. The degree of thymus dependence varies for different antigens, and slowly metabolised immunogens with repeating epitopes, generally polysaccharides or polymerised forms of protein, seem to be the most thymus ...
Burns, W H, Billups, L C, Notkins, A L
openaire   +3 more sources

Viral effects on antigen processing

Current Opinion in Immunology, 1999
Viruses have evolved numerous mechanisms that modulate MHC-mediated antigen presentation, which in turn protect infected cells from T-lymphocyte-mediated immunosurveillance. Recent studies of previously identified viral immunomodulatory proteins reveal the allelic specificity of these proteins, their ability to function in xenogeneic systems and the ...
Daniel M. Miller, Daniel D. Sedmak
openaire   +3 more sources

Viral interference with antigen presentation

Nature Immunology, 2002
CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells.
Jonathan W. Yewdell, Ann B. Hill
openaire   +3 more sources

FÆCAL ANTIGEN IN VIRAL HEPATITIS

The Lancet, 1970
Abstract An antigen has been detected in faecal extracts from 90 out of 220 patients with viral hepatitis and from 5 of 158 patients with other diseases. In viral hepatitis this antigen is present early in the disease and usually disappears within three weeks of the first appearance of dark urine.
G. Cross, A.A. Ferris, Ian D. Gust, J. Kaldor   +3 more
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ISCOMs and Immunostimulation with Viral Antigens

1989
With the dissection of microorganisms followed by biochemical and immunological characterization, antigens inducing protective immunity became recognized. Early attempts to use these isolated antigens as vaccines, i.e. subunit vaccines, showed that although immunogenic in situ as part of the microorganism, they were not immunogenic as purified antigens.
Bror Morein, Kristian Dalsgaard, Karin Lövgren, Ab Osterhaus, Bo Sundquist, Stefan Höglund   +5 more
openaire   +3 more sources