Results 271 to 280 of about 2,011,135 (332)

Preparation and immunogenicity studies of NvIBDV VP2-ferritin nanoparticles. [PDF]

BMC Vet Res
Gao S, Zhou X, Li X, Luo L, Yang K, Huang Y, Bao Y, Wu X, Guo Y, Li J, Shao Y, Wang L, Liu Z, Sun M, Liang L.   +14 more
europepmc   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

BK Virus-Specific T Cell Response Associated with HLA Genotypes, RhD Status, and CMV or EBV Serostatus in Healthy Donors for Optimized Cell Therapy. [PDF]

J Clin Immunol
Mora-Buch R, Tomás-Marín M, Pasamar H, Enrich E, Peña-Gómez C, Rudilla F.   +5 more
europepmc   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

Simple and High-Throughput Quantification of Mono- and Bivalent Foot-and-Mouth Disease Virus Vaccine Antigens by Differential Scanning Fluorimetry. [PDF]

Vaccines (Basel)
Yang Y, Chen X, Li M, Xin F, Zhao Y, Zhang C, Pan Y, He C, He S.   +8 more
europepmc   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Efficacy of modified-vaccinia Ankara vaccine as pre- and post-exposure prophylaxis against monkeypox sexual transmission in non-human primate model. [PDF]

Nat Commun
Herate C, Ferrier-Rembert A, Relouzat F, Gallouët AS, Pascal Q, Letscher H, Cavarelli M, Dereuddre-Bosquet N, Gros W, Delache B, Langlois S, Timera H, Jarjaval F, Bossevot L, Ludot C, Brua C, Lechemia M, Ferraris O, Silvestre N, Le Grand R, Tournier JN.   +20 more
europepmc   +1 more source

Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

Advanced Science, EarlyView.
This study proposes that adhesion–clutch can mediate both cell motility and immobilization depending on the force amplitude. Weak adhesion–clutch is well‐suited for cell migration, without forming strong adhesions that impede cell motility. It propels rapid dendritic cell migration controlled by extracellular chemicals, as well as pathologically ...
Kentarou Baba, Ami Fukushi‐Kumagai, Megumi Morisaki, Ryosuke Takeuchi, Zhize Xiao, Yoshikazu Nagashima, Mizuki Sakai, Yasuna Higashiguchi, Hiroko Katsuno‐Kambe, Asako Katsuma, Yoshihiro Ueda, Yuji Kamioka, Daisuke Kawauchi, Tatsuo Kinashi, Yonehiro Kanemura, Naoyuki Inagaki   +15 more
wiley   +1 more source

Infection with Mycobacterium tuberculosis alters the antibody response to HIV-1. [PDF]

PLoS Pathog
Zeeb M, Kusejko K, Hartnack S, Pasin C, Abela IA, Rusert P, Liechti T, Kadelka C, Notter J, Eichenberger A, Hoffmann M, Hirsch HH, Calmy A, Cavassini M, Labhardt ND, Bernasconi E, Günthard HF, Kouyos RD, Trkola A, Nemeth J, and the Swiss HIV Cohort Study.   +20 more
europepmc   +1 more source

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, EarlyView.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source