Results 291 to 300 of about 2,011,135 (332)
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Thymus dependence of viral antigens
Nature, 1975AFTER exposure of animals to most antigens, formation of antibody by cells of the B lymphocyte lineage requires helper effects of T lymphocytes1. The degree of thymus dependence varies for different antigens, and slowly metabolised immunogens with repeating epitopes, generally polysaccharides or polymerised forms of protein, seem to be the most thymus ...
Burns, W H, Billups, L C, Notkins, A L
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Viral effects on antigen processing
Current Opinion in Immunology, 1999Viruses have evolved numerous mechanisms that modulate MHC-mediated antigen presentation, which in turn protect infected cells from T-lymphocyte-mediated immunosurveillance. Recent studies of previously identified viral immunomodulatory proteins reveal the allelic specificity of these proteins, their ability to function in xenogeneic systems and the ...
Daniel M. Miller, Daniel D. Sedmak
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Delivery of antigens by viral vectors for vaccination.
Therapeutic Delivery, 2011Viral vectors have been developed as vaccine platforms for a number of pathogens and tumors. In particular, adenovirus (Ad)-based vectors expressing genes coding for pathogen or tumor antigens have proven efficacious to induce protective immunity. Major challenges in the use of Ad vectors are the high prevalence of anti-Ad immunity and the recent ...
Anja Krause, S. Worgall
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Viral interference with antigen presentation
Nature Immunology, 2002CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells.
Jonathan W. Yewdell, Ann B. Hill
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FÆCAL ANTIGEN IN VIRAL HEPATITIS
The Lancet, 1970Abstract An antigen has been detected in faecal extracts from 90 out of 220 patients with viral hepatitis and from 5 of 158 patients with other diseases. In viral hepatitis this antigen is present early in the disease and usually disappears within three weeks of the first appearance of dark urine.
G. Cross +3 more
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ISCOMs and Immunostimulation with Viral Antigens
1989With the dissection of microorganisms followed by biochemical and immunological characterization, antigens inducing protective immunity became recognized. Early attempts to use these isolated antigens as vaccines, i.e. subunit vaccines, showed that although immunogenic in situ as part of the microorganism, they were not immunogenic as purified antigens.
Bror Morein +5 more
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Uses of Biosensors in the Study of Viral Antigens
Immunological Investigations, 1997The introduction in 1990 of a new biosensor technology based on surface plasmon resonance has greatly simplified the measurement of binding interactions in biology. This new technology known as biomolecular interaction analysis makes it possible to visualize the binding process as a function of time by following the increase in refractive index that ...
van Regenmortel, M. H. +5 more
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Australia Antigen and Acute Viral Hepatitis
Annals of Internal Medicine, 1969Abstract Australia antigen (Au(1)) was found in the sera of 20% of 125 patients with acute viral hepatitis.
Alton I. Sutnick +2 more
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