Results 101 to 110 of about 68,768 (336)

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

EMBO Molecular Medicine, 2019
The current clinical care of glioblastomas leaves behind invasive, radio‐ and chemo‐resistant cells. We recently identified mammary‐derived growth inhibitor (MDGI/FABP3) as a biomarker for invasive gliomas.
Vadim Le Joncour, Pauliina Filppu, Maija Hyvönen, Minna Holopainen, S Pauliina Turunen, Harri Sihto, Isabel Burghardt, Heikki Joensuu, Olli Tynninen, Juha Jääskeläinen, Michael Weller, Kaisa Lehti, Reijo Käkelä, Pirjo Laakkonen   +13 more
doaj   +1 more source

Antihistamines for the common cold [PDF]

, 2015
Background : The common cold is an upper respiratory tract infection, most commonly caused by a rhinovirus. It affects people of all age groups and although in most cases it is self limiting, the common cold still causes significant morbidity ...
De Sutter, An, Saraswat, Avadhesh, van Driel, Marie   +2 more
core   +2 more sources

Managing Skin Diseases During Pregnancy: Treatment Discontinuation, Concerns and Physician Counselling

JEADV Clinical Practice, EarlyView.
Physiological changes during pregnancy can trigger or worsen dermatological conditions, yet evidence‐based guidance for safe management remains limited. In a cross‐sectional survey of 273 pregnant women, 33.7% reported having a skin disease, and 56% experienced worsening of symptoms.
Frederikke Seeberg, Anne Sofie Frølunde, Mette Deleuran, Line Kolding, Christian Vestergaard   +4 more
wiley   +1 more source

Acute Toxicity and Neurobehavioral Effects of Diphenhydramine in Chicks

The Journal of Poultry Science, 2012
The present study was undertaken to examine the acute toxicity (LD50) and neurobehavioral manifestations in the open-field activity and tonic immobility tests in 7-14 day-old chicks treated with the H1-receptor antagonist diphenhydramine.
Fouad K. Mohammad, Yaareb J. Mousa, Mohammad M. Hasan   +2 more
doaj   +1 more source

Treating Diphenhydramine Overdose: A Literature Review of Currently Available Treatment Methods

Toxics
From 2019 to 2020, antihistamines were found in 15% of all US drug overdose deaths, often co-administered with fentanyl, with 3.6% of overdose deaths due to antihistamines alone.
Jayna Patel, Joshua Edwards
doaj   +1 more source

An Open‐Label Phase 1b Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of ANX005 in Patients with Huntington's Disease

Movement Disorders, EarlyView.
Complement activation is implicated in Huntington's disease; ANX005 is a potent inhibitor of component C1q. ANX005 exhibited a generally manageable safety profile with rapid reduction in C1q in the cerebrospinal fluid. Functional ability on composite Unified Huntington's Disease Rating Scale and total functional capacity was maintained, with potential ...
Rajeev Kumar, Pinky Agarwal, Karen Anderson, Daniel Claassen, Marissa Dean, Andrew Duker, Burton Scott, Benjamin Hoehn, Ann Mongan, Ping Lin, Ellen Cahir‐McFarland, Lori Taylor, Glenn Morrison, Ted Yednock, Sanjay Keswani, Henk‐Andre Kroon   +15 more
wiley   +1 more source

Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers

Cogent Psychology, 2016
This research investigated the modulating effects of antihistamines—Loratadine, Fexofenadine, Meclizine, and Chlorpheniramine on cognitive (executive function, memory, attention, emotion regulation), mood, psychomotor performance, and sedation in healthy
Rawshan Zannat, Mir Muhammad Nasir Uddin, Md. Atiar Rahman, Jannatul Aklima, Md. Mamun Al Amin   +4 more
doaj   +1 more source

Impact of Sedative and Non-Sedative Antihistamines on the Impaired Productivity and Quality of Life in Patients with Pruritic Skin Diseases

Allergology International, 2010
Background: The impairment that pruritic skin diseases have on patient productivity at work, in the classroom, and in daily activities is substantial and needs to be characterized.
Hiroyuki Murota, Shun Kitaba, Mamori Tani, Mari Wataya-Kaneda, Hiroaki Azukizawa, Atsushi Tanemura, Noriko Umegaki, Mika Terao, Yorihisa Kotobuki, Ichiro Katayama   +9 more
doaj   +1 more source

Omalizumab rapidly improves angioedema‐related quality of life in adult patients with chronic spontaneous urticaria: X‐ACT study data [PDF]

, 2018
Background: The X‐ACT study aimed to examine the effect of omalizumab treatment on quality of life (QoL) in chronic spontaneous urticaria (CSU) patients with angioedema refractory to high doses of H1‐antihistamines. Methods: In X‐ACT, a phase III, double‐
Barbosa, Bernstein, Bork, Brooks, Choi, Finlay, Finlay, Grattan, Hallak, Herguner, James, Kaplan, Krieger, Maurer, Maurer, Maurer, McCormack, Metz, Metz, Saini, Saini, Shikiar, Staubach, Staubach, Weller, Weller, Weller, Zazzali, Zhao, Zuberbier   +29 more
core   +1 more source

Chemical constituents and antihistamine activity of Bixa orellana leaf extract

BMC Complementary and Alternative Medicine, 2013
BackgroundBixa orellana L. has been traditionally used in Central and South America to treat a number of ailments, including internal inflammation, and in other tropical countries like Malaysia as treatment for gastric ulcers and stomach discomfort.
Y. Yong, Z. Zakaria, A. Kadir, M. N. Somchit, Gwendoline Ee Cheng Lian, Z. Ahmad   +5 more
semanticscholar   +1 more source